[Hypercalcemia in a pediatric patient with ovarian dysgerminoma: A case report]. / Hipercalcemia en paciente pediátrica con disgerminoma ovárico: a propósito de un caso.

Hypercalcemia associated with malignant tumors is a rare entity in pediatrics (0.5-1.3 % of pediatric cancers). It responds to different pathophysiological mechanisms and the typical symptoms shown are usually nonspecific, but potentially serious. We present a clinical case of a 12-year-old patient with a bilateral ovarian dysgerminoma who was diagnosed with severe hypercalcemia at the onset, which required hyperhydration associated with loop diuretics, bisphosphonates and, eventually, the tumor resection surgery that allowed the final resolution of the clinical picture. Despite being a rare hydroelectric disorder in pediatrics, given the potential severity of hypercalcemia, early detection and treatment are important in order to avoid potential short- and long-term complications.

La hipercalcemia asociada a tumores malignos es una entidad poco frecuente en pediatría (0,5-1,3 % de los cánceres pediátricos). Es causada por diferentes mecanismos fisiopatológicos y los síntomas de presentación suelen ser inespecíficos, pero potencialmente graves. Presentamos un caso clínico de una paciente de 12 años con diagnóstico de disgerminoma ovárico bilateral. La enfermedad se presentó con hipercalcemia grave, tratada con hiperhidratación asociada a diuréticos de asa, bifosfonatos y, por último, la resección quirúrgica del tumor, que permitió la resolución definitiva del cuadro. A pesar de tratarse de un trastorno hidroeléctrico poco habitual en pediatría, dada la potencial gravedad de la hipercalcemia, es importante la detección y el tratamiento tempranos, con el fin de evitar complicaciones en el corto y el largo plazo.

Hipercalcemia en paciente pediátrica con disgerminoma ovárico: a propósito de un caso / Hypercalcemia in a pediatric patient with ovarian dysgerminoma: A case report

La hipercalcemia asociada a tumores malignos es una entidad poco frecuente en pediatría (0,5-1,3 % de los cánceres pediátricos). Es causada por diferentes mecanismos fisiopatológicos y los síntomas de presentación suelen ser inespecíficos, pero potencialmente graves. Presentamos un caso clínico de una paciente de 12 años con diagnóstico de disgerminoma ovárico bilateral. La enfermedad se presentó con hipercalcemia grave, tratada con hiperhidratación asociada a diuréticos de asa, bifosfonatos y, por último, la resección quirúrgica del tumor, que permitió la resolución definitiva del cuadro. A pesar de tratarse de un trastorno hidroeléctrico poco habitual en pediatría, dada la potencial gravedad de la hipercalcemia, es importante la detección y el tratamiento tempranos, con el fin de evitar complicaciones en el corto y el largo plazo

Hypercalcemia associated with malignant tumors is a rare entity in pediatrics (0.5-1.3 % of pediatric cancers). It responds to different pathophysiological mechanisms and the typical symptoms shown are usually nonspecific, but potentially serious. We present a clinical case of a 12-year-old patient with a bilateral ovarian dysgerminoma who was diagnosed with severe hypercalcemia at the onset, which required hyperhydration associated with loop diuretics, bisphosphonates and, eventually, the tumor resection surgery that allowed the final resolution of the clinical picture.Despite being a rare hydroelectric disorder in pediatrics, given the potential severity of hypercalcemia, early detection and treatment are important in order to avoid potential short- and long-term complications.

[Chagas' disease as a cause of cerebral mass in a patient with lymphoblastic leukemia in remission]. / Enfermedad de Chagas como causa de masa cerebral ocupante en paciente con leucemia linfoblástica en remisión.

We report the case of a 15-year-old female patient, native of the province of Chaco, diagnosed with lymphoblastic leukemia 2 years ago. She was currently in maintenance therapy, with good response to treatment. Twenty days before she began with headache and fever. At admission, blood cultures were negative, and brain computed tomography showed a hypodense lesion with involvement of white matter in left occipital-parietal area. A brain MRI was performed, and a hypointense left occipital lesion was observed in T1. The lesion showed peripheral gadolinium enhancing and was hyperintense on T2, with a hypodense central area surrounded by significant edema with mass effect. Chagas serology was positive, as well as the parasitemia. The patient was treated with benznidazole, with good response to therapy: a significant clinical improvement and mass reduction were observed, within the first month of treatment.

Enfermedad de chagas como causa de masa cerebral ocupante en paciente con leucemia linfoblástica en remisión / Chagas' disease as a cause of cerebral mass in a patient with lymphoblastic leukemia in remission

Se presenta el caso de una paciente de 15 años, oriunda de la provincia de Chaco, con diagnóstico de leucemia linfoblástica hace 2 años, actualmente en mantenimiento, con buena respuestaal tratamiento. El motivo de consulta fue cefalea y fiebre de 20 días de evolución. Al ingreso se realizaron: hemocultivos(negativos) y tomografía computada de cerebro, que mostró una lesión hipodensa con compromiso de sustancia blanca a nivel occípito-parietal izquierdo. Se realizó una resonancia nuclear magnética de cerebro y se observó lesión occipital izquierdahipointensa en T1 e hiperintensa en T2, con refuerzo periférico con gadolinio y área central hipodensa, rodeada de importante edema con efecto de masa. La serología para Chagas fuepositiva, como así también la parasitemia. Inició tratamientocon benznidazol, con buena evolución clínica y reducción de la lesión al mes de tratamiento.

We report the case of a 15-year-old female patient, native of the province of Chaco, diagnosed with lymphoblastic leukemia 2 years ago. She was currently in maintenance therapy, with good response to treatment. Twenty days before she began with headacheand fever. At admission, blood cultures were negative, and brain computed tomography showed a hypodense lesionwith involvement of white matter in left occipital-parietal area. A brain MRI was performed, and a hypointense left occipital lesion was observed in T1. The lesion showed peripheral gadoliniumenhancing and was hyperintense on T2, with a hypodense central area surrounded by significant edema with mass effect. Chagas serology was positive, as well as the parasitemia.The patient was treated with benznidazole, with good response to therapy: a significant clinical improvement and mass reduction were observed, within the first month of treatment.