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Ann Diagn Pathol ; 49: 151607, 2020 Dec.
Article in English | MEDLINE | ID: mdl-32949894

ABSTRACT

Recently, several trials demonstrated the safety of omitting axillary lymph node dissection in clinically N0 patients with positive sentinel nodes in select subgroups. However, this fact is still troublesome to clarify to surgeons and clinicians, as they used to perform intraoperative examination of the sentinel node and axillary dissection for many years. Hence, we decided to review our practice. This is to firstly highlight the predictive factors of node metastasis and secondly, to evaluate the effectiveness of intraoperative examination of the sentinel node. There were 406 total procedures. The rate of positive lymph nodes in the final diagnosis was 27%. Factors associated with metastasis were age, tumour size, TNM classification, tumour grade, vascular invasion, molecular classification and KI-67 index. The rate of reoperation was 6.2% in cases with final positive nodes, however, the complementary ALND was justified in only 2.7%. Forty-nine percent of SLN were examined during surgery (IOESLN), whereby the false negative rate was 11.8%. Sixty-three intraoperative examinations were necessary to prevent a second operation on a patient. We recommend changing the clinical management of the axilla, resulting in fewer ALNDs in selected cN0, SLN-positive patients. In keeping with recent large clinical trial (ACOSOG Z0011, AMAROS and OTOASOR) data, our results support that intraoperative exam in selected cN0, SLN-positive Belgian patients is no longer effective.


Subject(s)
Breast Neoplasms/pathology , Lymphatic Metastasis/diagnosis , Neoplasm Staging/methods , Sentinel Lymph Node Biopsy , Adult , Aged , Aged, 80 and over , Axilla , Belgium , Carcinoma, Intraductal, Noninfiltrating/pathology , Female , Humans , Lymph Node Excision , Middle Aged , Retrospective Studies
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