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Eur J Cancer ; 41(17): 2682-9, 2005 Nov.
Article in English | MEDLINE | ID: mdl-16291085

ABSTRACT

The aim of this study was to assess the efficacy and adverse effects of 2-chlorodeoxyadenosine (2-CdA) and cytosine arabinoside (Ara-C) in children with refractory Langerhans cell histiocytosis (LCH) and haematopoietic dysfunction. Ten patients, with a median age at diagnosis of 0.5 years, were enrolled in this study. Treatment comprised at least two courses of Ara-C (1000 mg/m(2)/d) and 2-CdA (9 mg/m(2)/d) administered for 5d every 4 weeks; subsequent median follow-up was 2.8 years (range 0.03-6.4 years). Among the 7 patients who received at least two courses of therapy, disease activity decreased in 6 patients, and control of disease was achieved in all patients after a median delay of 5.5 months. All patients suffered World Health Organisation (WHO) grade 4 haematological toxicity. Two septic deaths occurred shortly after administration of the first course of 2-CdA/Ara-C; a third patient was withdrawn from the trial after the first course and subsequently died following haematopoietic stem cell transplantation. This series is small, but we conclude that 2-CdA and Ara-C combined chemotherapy probably has major activity in childhood refractory Langerhans cell histiocytosis.


Subject(s)
Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Hematologic Diseases/complications , Histiocytosis, Langerhans-Cell/drug therapy , Chronic Disease , Cladribine/administration & dosage , Cytarabine/administration & dosage , Drug Therapy, Combination , Female , Humans , Infant , Infusions, Intravenous , Male , Pilot Projects , Survival Analysis
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