ABSTRACT
Lichen planus pemphigoides is a rare autoimmune subepidermal blistering disease clinically and histopathologically characterized by features of lichen planus and bullous pemphigoid. We describe a case of refractory lichen planus pemphigoides successfully treated with the selective and reversible Janus kinase-1/2 inhibitor, baricitinib.
Subject(s)
Azetidines , Lichen Planus , Pemphigoid, Bullous , Skin Diseases, Vesiculobullous , Humans , Lichen Planus/drug therapy , Pemphigoid, Bullous/drug therapy , Azetidines/therapeutic use , Janus KinasesABSTRACT
A 56-year-old man was hospitalized with a history of diffuse abdominal pain. Cutaneous examination revealed an erythematous to violaceous, infiltrative nodule of the umbilicus. Histologic examination demonstrated poorly differentiated adenocarcinoma. Abdominal tomography showed advanced pancreatic cancer with metastatic involvement of the liver and the diagnosis of pancreatic adenocarcinoma with umbilical metastasis -- Sister Mary Joseph's nodule.
