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J Clin Pharm Ther ; 43(2): 273-275, 2018 Apr.
Article in English | MEDLINE | ID: mdl-28833364

ABSTRACT

WHAT IS KNOWN AND OBJECTIVE: Limited data are available on eosinophilia as a drug adverse event. We describe a case of eosinophilia from lenalidomide therapy. CASE DESCRIPTION: A 50-year-old woman received lenalidomide, dexamethasone and cyclophosphamide as POEMS syndrome treatment. Eosinophil count rose during lenalidomide treatment and decreased in the periods off treatment. Naranjo nomogram suggested a probable association between the use of lenalidomide and eosinophilia. WHAT IS NEW AND CONCLUSION: Eosinophilia has rarely been described with lenalidomide. This case shows a clear temporal relationship between lenalidomide and eosinophilia.


Subject(s)
Eosinophilia/chemically induced , Thalidomide/analogs & derivatives , Angiogenesis Inhibitors/therapeutic use , Antineoplastic Agents, Hormonal/therapeutic use , Cyclophosphamide/therapeutic use , Dexamethasone/therapeutic use , Female , Humans , Lenalidomide , Middle Aged , POEMS Syndrome/drug therapy , Thalidomide/adverse effects , Thalidomide/therapeutic use
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