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The 2019-2020 Dengue Fever Epidemic: Genomic Markers Indicating Severity in Dominican Republic Children.
Simpson, Brittany N; Mejía Sang, Miguel E; Collado Puello, Yonairy; Diaz Brockmans, Elvira J; Díaz Soto, María F; Rivera Defilló, Stephanie M; Taveras Cruz, Karla M; Santiago Pérez, Javier O; Husami, Ammar; Day, Melissa E; Pilipenko, Valentina; Mena, Rafael; Mota, Cesár; Hostetter, Margaret K; Muglia, Louis J; Schlaudecker, Elizabeth; Gonzalez Del Rey, Javier; Martin, Lisa J; Prada, Carlos E.
J Pediatric Infect Dis Soc ; 12(3): 169-172, 2023 Apr 18.
Article in English | MEDLINE | ID: mdl-36537278

ABSTRACT

We performed an observational cohort study to assess associations between genetic factors of dengue fever (DF) severity in children in the Dominican Republic. A total of 488 participants had serologically confirmed DF. We replicated the association between the IFIH1 gene (rs1990760) and severe DF (n = 80/488, p = 0.006) and identified novel associations needing further investigation.


Subject(s)
Dengue , Severe Dengue , Humans , Child , Dengue/diagnosis , Dengue/epidemiology , Dominican Republic/epidemiology , Cohort Studies , Genomics
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