ABSTRACT
BACKGROUND: The Affective Symptoms Scale (ASRS) is a unique instrument designed to separately measure depressive and manic symptoms in mood disorders. We validated the ASRS against the Patient Health Questionnaire (PHQ-9) and the Quick Inventory of Depressive Symptomatology (QIDS-16). METHODS: A retrospective study of 258 patients who completed the PHQ-9, QIDS-16 and ASRS as part of routine clinical care. To establish meaningful clinical thresholds for the depression subscale of the ASRS, it was equated with the QIDS and the PHQ-9. RESULTS: The depression subscale of the ASRS had significant positive correlations with the QIDS-16 and the PHQ-9 (respectively, r= 0.8, t[253] = 19.8, p < 0.001, and r= 0.8, t[245] = 28.2, p < 0.001). The equipercentile equating method with the PHQ-9 indicated that the thresholds corresponded to ASRS depression subscale scores of 5.4, 10.6, 16.1, and 23. Equating with the QIDS indicated that thresholds corresponded to ASRS depression subscale scores of 5.1, 11, 18.4, and 27.5. LIMITATIONS: Limitations include a small sample size that did not allow more detailed statistical analysis, such as Item Response Theory. The population is a heterogenous population at a university outpatient setting. CONCLUSIONS: The ASRS depression subscale significantly correlated with the PHQ-9 and QIDS-16. Our proposed threshold scores for the ASRS are 5, 11, 16 and 23 to indicated mild, moderate, severe and very severe depression respectively.
Subject(s)
Depression , Depression/diagnosis , Humans , Psychiatric Status Rating Scales , Psychometrics , Retrospective Studies , Self ReportSubject(s)
Dendritic Cells/radiation effects , Graft Survival , Heart Transplantation/immunology , Histocompatibility Antigens Class II/immunology , Animals , Cyclosporins/therapeutic use , Dendritic Cells/immunology , Histocompatibility Antigens Class II/analysis , Rats , Rats, Inbred Strains , Transplantation, Homologous , Whole-Body IrradiationSubject(s)
Genes, MHC Class II , Graft Survival , Heart Transplantation/immunology , Histocompatibility Antigens Class II/immunology , Animals , Cyclosporins/therapeutic use , Gene Expression , Rats , Rats, Inbred Strains , Transplantation, Heterotopic , Transplantation, Homologous , Whole-Body IrradiationSubject(s)
Immunosuppressive Agents , Animals , Anti-Bacterial Agents/therapeutic use , Autoimmune Diseases/drug therapy , Guanidines/therapeutic use , Humans , Immunosuppressive Agents/adverse effects , Immunosuppressive Agents/pharmacology , Immunosuppressive Agents/therapeutic use , Mycophenolic Acid/analogs & derivatives , Mycophenolic Acid/therapeutic use , Organ Transplantation , Polyenes/therapeutic use , Ribonucleosides/therapeutic use , Sirolimus , TacrolimusABSTRACT
A retrospective study of the results of dipstick testing and microscopical examination of urine from 10 050 men undergoing health screening showed a prevalence of occult haematuria of 2.5%. Those patients with occult haematuria who were resident in the United Kingdom and registered with a general practitioner were identified and a questionnaire sent to their general practitioners asking what further investigations had been performed. The response rate was 92% (152/165 inquiries). Fifty nine general practitioners (39%) had not instigated any investigations. Among the 76 patients who underwent some further investigations abnormalities were found in 21 (28%); and among those fully investigated by examination of midstream urine, intravenous urography, and cystoscopy abnormalities were found in 12(50%). These included bladder neoplasms (two; one in a patient aged 37), epithelial dysplasia (one), staghorn calculi (one), and chronic reflux nephropathy (one). It is proposed that occult haematuria should be fully investigated regardless of the age of the patient.
