ABSTRACT
Dysregulation of metabolic functions in the liver impacts the development of diabetes and metabolic disorders. Normal liver function can be compromised by increased inflammation via the activation of signaling such as nuclear factor (NF)-κB signaling. Notably, we have previously identified lysine demethylase 2A (KDM2A)-as a critical negative regulator of NF-κB. However, there are no studies demonstrating the effect of KDM2A on liver function. Here, we established a novel liver-specific Kdm2a knockout mouse model to evaluate KDM2A's role in liver functions. An inducible hepatic deletion of Kdm2a, Alb-Cre-Kdm2afl/fl (Kdm2a KO), was generated by crossing the Kdm2a floxed mice (Kdm2afl/fl) we established with commercial albumin-Cre transgenic mice (B6.Cg-Tg(Alb-cre)21Mgn/J). We show that under a normal diet, Kdm2a KO mice exhibited increased serum alanine aminotransferase (ALT) activity, L-type triglycerides (TG) levels, and liver glycogen levels vs. WT (Kdm2afl/fl) animals. These changes were further enhanced in Kdm2a liver KO mice in high-fat diet (HFD) conditions. We also observed a significant increase in NF-κB target gene expression in Kdm2a liver KO mice under HFD conditions. Similarly, the KO mice exhibited increased immune cell infiltration. Collectively, these data suggest liver-specific KDM2A deficiency may enhance inflammation in the liver, potentially through NF-κB activation, and lead to liver dysfunction. Our study also suggests that the established Kdm2afl/fl mouse model may serve as a powerful tool for studying liver-related metabolic diseases.
Subject(s)
Liver Diseases , NF-kappa B , Mice , Animals , NF-kappa B/genetics , NF-kappa B/metabolism , Liver/metabolism , Inflammation/genetics , Inflammation/metabolism , Signal Transduction , Liver Diseases/metabolismABSTRACT
Bringing awareness to this major public health issue.
Subject(s)
Alzheimer Disease , Dementia , Humans , Public HealthABSTRACT
U.S. maternal mortality rate continues to rise; women's abortion rights are challenged.
Subject(s)
Abortion, Induced/legislation & jurisprudence , Maternal Mortality/trends , Reproductive Health/legislation & jurisprudence , Reproductive Health/trends , Reproductive Rights/legislation & jurisprudence , Women's Health/legislation & jurisprudence , Women's Health/trends , Abortion, Induced/statistics & numerical data , Adult , Aged , Aged, 80 and over , Female , Forecasting , Humans , Middle Aged , United StatesABSTRACT
'The Pause' honors patients who have passed and the medical team that cared for them.
ABSTRACT
Freshman congresswoman Lauren Underwood brings nursing and health care policy experience to the table.
ABSTRACT
For more than 30 years, Judy Murphy has been a leader in nursing informatics.
Subject(s)
Nursing Informatics , Electronic Health Records , History, 20th Century , History, 21st Century , Humans , Nurse's Role , United StatesABSTRACT
Updated several times a week with posts by a wide variety of authors, AJN's blog Off the Charts allows us to provide more timely-and often more personal-perspectives on professional, policy, and clinical issues. Best of the Blog will be a regular column to draw the attention of AJN readers to posts we think deserve a wider audience. To read more, please visit: www.ajnoffthecharts.com.
ABSTRACT
As the largest part of the health care workforce, it's nurses, says Leslie Mancuso, who will make the difference.
Subject(s)
Developing Countries , Leadership , Nurses , Power, Psychological , Female , Humans , Nurses, InternationalABSTRACT
As part of its Raise the Voice campaign to showcase nurses who are key players in transforming health care, the American Academy of Nursing has identified nurses they call edge runners-"practical innovators who have led the way in bringing new thinking and new methods to a wide range of health care challenges." This is the seventh in AJN's series of profiles of these nursing innovators. Read and be proud of what nurses can accomplish.
Subject(s)
Delivery of Health Care, Integrated/organization & administration , Mental Health Services/organization & administration , Primary Health Care/organization & administration , Models, OrganizationalABSTRACT
Susan Schnall speaks about the lingering effects of Agent Orange-and what remains to be done about them.
Subject(s)
2,4,5-Trichlorophenoxyacetic Acid/toxicity , 2,4-Dichlorophenoxyacetic Acid/toxicity , Congenital Abnormalities/etiology , Hazardous Substances/toxicity , Health Services Accessibility , Polychlorinated Dibenzodioxins/toxicity , Social Conditions , Agent Orange , Attitude of Health Personnel , Congenital Abnormalities/therapy , Humans , Internationality , Nurse's Role , Veterans Disability Claims/legislation & jurisprudence , Vietnam , Vietnam ConflictABSTRACT
Updated several times a week with posts by a wide variety of authors, AJN's blog Off the Charts allows us to provide more timely-and often more personal-perspectives on professional, policy, and clinical issues. Best of the Blog will be a regular column to bring AJN readers recent posts that we think deserve a wider audience. To read more, please visit: www.ajnoffthecharts.com.
Subject(s)
Labor Pain , Labor, Obstetric , Nurse-Patient Relations , Female , Humans , PregnancyABSTRACT
RATIONALE: Serious neurological concomitants of alcoholism include Wernicke's encephalopathy (WE), Korsakoff's syndrome (KS), and hepatic encephalopathy (HE). OBJECTIVES: This study was conducted in animal models to determine neuroradiological signatures associated with liver damage caused by carbon tetrachloride (CCl4), thiamine deficiency caused by pyrithiamine treatment, and nonspecific nutritional deficiency caused by food deprivation. METHODS: Magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) were used to evaluate brains of wild-type Wistar rats at baseline and following treatment. RESULTS: Similar to observations in ethanol (EtOH) exposure models, thiamine deficiency caused enlargement of the lateral ventricles. Liver damage was not associated with effects on cerebrospinal fluid volumes, whereas food deprivation caused modest enlargement of the cisterns. In contrast to what has repeatedly been shown in EtOH exposure models, in which levels of choline-containing compounds (Cho) measured by MRS are elevated, Cho levels in treated animals in all three experiments (i.e., liver damage, thiamine deficiency, and food deprivation) were lower than those in baseline or controls. CONCLUSIONS: These results add to the growing body of literature suggesting that MRS-detectable Cho is labile and can depend on a number of variables that are not often considered in human experiments. These results also suggest that reductions in Cho observed in humans with alcohol use disorder (AUD) may well be due to mild manifestations of concomitants of AUD such as liver damage or nutritional deficiencies and not necessarily to alcohol consumption per se.
Subject(s)
Alcoholism/complications , Brain/pathology , Food Deprivation/physiology , Liver Diseases, Alcoholic/physiopathology , Malnutrition/physiopathology , Thiamine Deficiency/pathology , Analysis of Variance , Animals , Choline/analysis , Disease Models, Animal , Ethanol/adverse effects , Hepatic Encephalopathy/chemically induced , Hepatic Encephalopathy/pathology , Humans , Magnetic Resonance Imaging , Magnetic Resonance Spectroscopy , Male , Rats , Rats, Wistar , Thiamine Deficiency/cerebrospinal fluid , Thiamine Deficiency/etiologyABSTRACT
A nurse-led initiative trains law enforcement to effectively interact with people with mental illness.
Subject(s)
Cooperative Behavior , Mental Disorders/nursing , Nursing Staff , Police , HumansABSTRACT
As part of its Raise the Voice campaign to showcase nurses who are key players in transforming health care, the American Academy of Nursing has identified nurses they call edge runners -"practical innovators who have led the way in bringing new thinking and new methods to a wide range of health care challenges." This is the fifth in AJN's series of profiles of these nursing innovators. Read and be proud of what nurses can accomplish.
Subject(s)
Nursing Process , Patient-Centered Care , Models, Nursing , Pilot Projects , United StatesSubject(s)
Adolescent Behavior/psychology , Diabetes Mellitus, Type 1/drug therapy , Diabetes Mellitus, Type 1/psychology , Menstruation/physiology , Adaptation, Psychological , Adolescent , Diabetes Complications , Female , Humans , Male , New York City , Stress, Psychological/etiology , Young AdultSubject(s)
Child Abuse, Sexual/ethnology , Homeless Youth/ethnology , Vulnerable Populations/ethnology , Adolescent , Asia, Southeastern/ethnology , Asian People , Child Abuse, Sexual/prevention & control , Child Abuse, Sexual/rehabilitation , Counseling/organization & administration , Female , Humans , MinnesotaABSTRACT
A past nursing model for 'chronically critically ill' patients provides lessons for health care today.As part of its Raise the Voice campaign to showcase nurses who are key players in transforming health care, the American Academy of Nursing has identified nurses they call edge runners-"practical innovators who have led the way in bringing new thinking and new methods to a wide range of health care challenges." This is the fourth in AJN's series of profiles of these nursing innovators. Read and be proud of what nurses can accomplish.
Subject(s)
Chronic Disease/nursing , Continuity of Patient Care/history , Intensive Care Units/history , Long-Term Care/history , Continuity of Patient Care/organization & administration , History, 20th Century , Humans , Intensive Care Units/organization & administration , Long-Term Care/organization & administration , Organizational InnovationABSTRACT
A nurse-managed health care network offers 'one-stop shopping' for low-income patients.As part of its Raise the Voice campaign to showcase nurses who are key players in transforming health care, the American Academy of Nursing has identified nurses they call edge runners-"practical innovators who have led the way in bringing new thinking and new methods to a wide range of health care challenges." This is the third in AJN's series of profiles of these nursing innovators. Read and be proud of what nurses can accomplish.
