ABSTRACT
Numerous human diseases are linked to a biochemical condition known as oxidative stress (OS). Antioxidants are therefore becoming increasingly important as potential disease prevention and therapeutic agents. Since OS is a multi-stressor event, agents combining a range of different antioxidant properties, such as redox catalysis and metal binding, might be more effective and selective than mono-functional agents. Selenium derivatives of aniline and pyridine combine redox activity with metal binding properties. These multifunctional agents have a distinct electrochemical profile, and exhibit good catalytic activity in the glutathione peroxidase mimic and metallothionein assays. They also show antioxidant activity in a skin cell model of UVA-induced stress. These compounds might therefore provide the basis for novel agents combining two or more distinct antioxidant properties.
Subject(s)
Antioxidants/chemical synthesis , Antioxidants/chemistry , Catalysis , Cell Line , Copper/chemistry , Electrochemistry , Fibroblasts , Humans , Ligands , Molecular Structure , Peroxidase/metabolism , Reactive Oxygen Species/chemistryABSTRACT
New asymmetric organotellurides exhibiting good antioxidant properties in vitro and in cell culture can be attached to human serum albumin.
Subject(s)
Antioxidants/chemical synthesis , Cell Survival/drug effects , Organometallic Compounds/chemical synthesis , Serum Albumin/metabolism , Tellurium/pharmacology , Antioxidants/pharmacology , Glutathione Peroxidase/metabolism , Humans , Kinetics , Lung Neoplasms/drug therapy , Lung Neoplasms/metabolism , Metallothionein/metabolism , Organometallic Compounds/pharmacology , Peroxides/chemistry , Phenols/chemistry , Sulfhydryl Compounds/chemistry , Tellurium/chemistry , Zinc/metabolismABSTRACT
Integrated catalysts as redox sensitisers towards cancer.
Subject(s)
PC12 Cells/drug effects , Quinones/metabolism , Quinones/pharmacology , Animals , Catalysis , Cell Survival/drug effects , Electrochemistry , Hydrogen Peroxide/chemistry , Hydrogen Peroxide/metabolism , Molecular Structure , Neoplasms/drug therapy , Neoplasms/metabolism , Neoplasms/pathology , Oxidation-Reduction , Oxidative Stress/drug effects , PC12 Cells/metabolism , Quinones/chemistry , RatsABSTRACT
Kynurenines are formed as part of the tryptophan metabolism and are known to exhibit pro- and anti-oxidant activities in vitro. The mapping of these biological redox-systems and identification of potential in vivo targets are therefore of great interest in cellular physiology. Here the redox-behavior of different kynurenines and anthranilic acids is evaluated electrochemically and compared to that of simple model compounds. Electrochemical results are correlated with the activity of these compounds in redox-bioassays where 3-hydroxyanthranilic acid and 3-hydroxykynurenine have significant redox-activity. The specific electrochemical redox-behavior of these two compounds, indicating a particular redox-mechanism involving the hydroxyl group, can be used to rationalize these findings. The results indicate that tryptophan metabolites can undergo a range of complex redox-reactions in vivo whose precise nature critically depends on structural details. As a consequence, some of the kynurenines have the potential to contribute to neuronal damage in brain disorders and stroke.
