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1.
Stem Cells Transl Med ; 10(12): 1581-1587, 2021 12.
Article in English | MEDLINE | ID: mdl-34515419

ABSTRACT

Debilitating diseases of the eye represent a large unmet medical need potentially addressable with stem cell-based approaches. Over the past decade, the California Institute for Regenerative Medicine (CIRM) has funded and supported the translation, from early research concepts to human trials, of therapeutic stem cell approaches for dry age-related macular degeneration, retinitis pigmentosa, and limbal stem cell deficiency. This article chronicles CIRM's journey in the ophthalmology field and discusses some key challenges and questions that were addressed along the way as well as questions that remain.


Subject(s)
Ophthalmology , Humans , Regenerative Medicine , Stem Cell Transplantation , Stem Cells
2.
Stem Cells Transl Med ; 9(10): 1129-1136, 2020 10.
Article in English | MEDLINE | ID: mdl-32619326

ABSTRACT

The California Institute for Regenerative Medicine (CIRM) has a mission to accelerate stem cell treatments to patients with unmet medical needs. This perspective describes successful examples of work funded by CIRM's New Cell Lines and Tools and Technologies Initiatives, which were developed to address bottlenecks to stem cell research and translation. The tools developed through these programs evolved from more discovery-oriented technologies, such as disease models, differentiation processes, and assays, to more translation focused tools, including scalable good manufacturing processes, animal models, and tools for clinical cell delivery. These tools are available to the research community and many are facilitating translation of regenerative therapeutics today.


Subject(s)
Regenerative Medicine/methods , Stem Cell Transplantation/methods , Translational Research, Biomedical/methods , Animals , Disease Models, Animal , Humans , Mice , Stem Cell Research
3.
Stem Cells Transl Med ; 4(8): 863-7, 2015 Aug.
Article in English | MEDLINE | ID: mdl-26136501

ABSTRACT

Heart disease due to myocardial infarction and the ensuing heart failure represent a major unmet medical need. Approved treatments do not prevent loss of cardiac muscle or reduce scar formation, both of which weaken heart function. Cell-based therapies currently being investigated both preclinically and clinically have the potential to address these underlying problems either by actually replacing lost tissue or by supplying paracrine growth factors that may have multiple beneficial effects such as reduction of inflammation, increase of blood supply, improvement in cell survival, and reduction of scar size. The best cell types, stage of disease to target, and delivery method to improve heart function are currently unclear. The California Institute for Regenerative Medicine supports multiple different cell-therapy strategies for heart disease, offering hope that improved treatments will be available for patients in the future.


Subject(s)
Cell- and Tissue-Based Therapy , Myocardial Infarction/therapy , Regenerative Medicine , Stem Cell Transplantation/trends , Heart Failure/therapy , Humans , Myocardial Infarction/physiopathology , Myocardium/pathology
4.
Stem Cells Transl Med ; 4(3): 207-10, 2015 Mar.
Article in English | MEDLINE | ID: mdl-25637191

ABSTRACT

Despite available medical therapy and organ transplantation, a significant unmet medical need remains for the treatment of liver failure, end-stage liver disease, and liver-based inborn errors of metabolism. Liver cell transplantation has the potential to address this need; however, the field is in search of a suitable cell therapeutic. The ability to reproducibly generate a well-characterized source of engraftable and functional liver cells has continued to be a challenge. Recent progress with tissue-derived stem/progenitor cells and pluripotent stem cell-derived cells now offers the field the opportunity to address this challenge.


Subject(s)
Cell- and Tissue-Based Therapy , Liver Diseases/therapy , Pluripotent Stem Cells/transplantation , Stem Cell Transplantation , Cell- and Tissue-Based Therapy/methods , Cell- and Tissue-Based Therapy/trends , Humans
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