The biological and clinical significance of tumor markers in tissue extracts.

A quantitative study of carcinoembryonic antigen (CEA) activity was made in plasma and in 25 colorectal tumors, 30 lung tumors, 20 breast tumors, and 20 fibrocystic dysplasias of the breast. The CEA content was detected by enzyme assays (EIA) in solid phase. In colorectal cancer the amount of CEA ranged from 40 to 800 ng/mg protein. In lung cancer, values ranged from 5 to 130 ng/mg protein. Differences in mean content of CEA between normal and cancer yielded the highest significant value of P less than 0.001. In 54 of 95 of cases, high concentrations of CEA in tissues were associated with high values in plasma. In fibrocystic dysplasia of the breast, the CEA concentration levels were lower than in cases of breast carcinoma. The CEA concentration values in fibrocystic dysplasia were associated with the epithelial proliferation and the degree of dysplasia. Therefore, the presence of elevated CEA tissues values may be indicative of patients with higher risk of malignant transformation.

[Influence of pipotiazine on schizophrenia]. / Modifications des schizophrénies par la pipotiazine.

This study is an account of thirty cases of schizophrenia treated experimentally in open with Pipotiazine (19366 R.P.), these cases, of the Kraepelin's Dementia Praecox type, in serious or complicated forms necessitating important measures of hospital care. The quantitative and qualitative therapeutic results, very favourable and original, consist in the transformation of these serious forms into simple or latent forms of schizophrenia. The undesirable effects, rare and always regressive, were all the smaller in the measure as the favourable effects were greater, which indicates a precise impact on certain determinants (central control of affectivity and the representation of the autonomous body). Pipotiazine develops a curative process in the personality characterized mainly by the emergence of lucidity, narcissistic euphoria (anti-persecutory and anti-splintering) and by the apprehension of intrapsychic splitting, setting in motion the necessary psychological task of reconstruction.