A meta-analysis of post-exercise outcomes in people with amyotrophic lateral sclerosis.

Objective: To systematically evaluate post-exercise outcomes related to function and quality of life in people with ALS. Methods: PRISMA guidelines were used for identifying and extracting articles. Levels of evidence and quality of articles were judged based on The Oxford Centre for Evidence-based Medicine Levels of Evidence and the QualSyst. Outcomes were analyzed with Comprehensive Meta-Analysis V2 software, random effects models, and Hedge's G. Effects were examined at 0-4 months, up to 6 months, and > 6 months. Pre-specified sensitivity analyses were performed for 1) controlled trials vs. all studies and 2) ALSFRS-R bulbar, respiratory, and motor subscales. Heterogeneity of pooled outcomes was computed with the I2 statistic. Results: 16 studies and seven functional outcomes met inclusion for the meta-analysis. Of the outcomes explored, the ALSFRS-R demonstrated a favorable summary effect size and had acceptable heterogeneity and dispersion. While FIM scores demonstrated a favorable summary effect size, heterogeneity limited interpretations. Other outcomes did not demonstrate a favorable summary effect size and/or could not be reported due to few studies reporting outcomes. Conclusions: This study provides inconclusive guidance regarding exercise regimens to maintain function and quality of life in people with ALS due to study limitations (e.g., small sample size, high attrition rate, heterogeneity in methods and participants, etc.). Future research is warranted to determine optimal treatment regimens and dosage parameters in this patient population.

Handgrip exercise induces sex-specific mean arterial pressure and oxygenation responses but similar performance fatigability.

Women exhibit an attenuated exercise pressor reflex (EPR) when compared to men. The influence of sex-specific mechanisms related to the EPR and performance fatigability remain to be fully elucidated. The purpose was to determine the impact of oxygenation and metabolic efficiency on sex-specific performance fatigability and increases in mean arterial pressure (MAP) resulting from a fatiguing isometric handgrip (IHG). Twenty-four adults volunteered to perform an IHG at 25% at maximal voluntary isometric contractions (MVICs). Pre- and posttest MVICs were conducted to quantify performance fatigability. MAP was collected at 3 timepoints. A near-infrared spectroscopy device was attached to the forearm to derive the following signals: oxy[haem], deoxy[haem], total[haem], and diff[haem]. These values were normalized and examined across time in 5% segments of time-to-task-failure. Metabolic efficiency was defined as the ratio force:deoxy[haem]. During the IHG, there was a decline in oxy[haem] for the men (b = -0.075), whereas the women demonstrated an increase (b = 0.117). For the men, the diff[haem] tracked the mean oxy[haem] response, but there was no change for the women. The men exhibited greater declines in metabolic efficiency, yet there were no sex differences in PF (46.6 ± 9.7% vs. 45.5 ± 14.2%). For relative MAP, the men (24.5 ± 15.1%) exhibited a greater (p = .03) increase than the women (11.0 ± 17.6%). These results indicated the EPR was more prominent for the men, perhaps due to differences in mechanical stimuli and a lack of ability to maintain metabolic efficiency. However, these physiological differences did not induce a sex difference in performance fatigability.

The Influence of Motor Unit Number and Muscle Activation on Early Phase Rate of Torque Development in Younger and Older Men.

This study examined the influence of muscle activation and motor unit number estimation (MUNE) on early phase voluntary rate of torque development (RTD) in younger (YM) and older (OM) men. Thirty-two YM (n = 17; Age = 22 yrs) and OM (n = 15; Age = 74 yrs) volunteered to participate in this study. Early phase RTD (first 50 ms of a rapid isometric contraction; RTD50) and normalized surface electromyography (first 50 ms of muscle excitation; nEMG50) were recorded from the right quadricep muscle group. MUNE was examined from the right vastus lateralis. Multiple linear regression analyses revealed that nEMG50 had a significant effect on RTD50 independent of age group (p ≤ 0.001). nEMG50 had a significant effect on RTD50 in the OM group (p = 0.037). MUNE had no effect on RTD50 independent of age. Older adults may depend more on muscle activation at contraction onset of early phase RTD compared to younger adults.

Increases in motor unit action potential amplitudes are related to muscle hypertrophy following eight weeks of high-intensity exercise training in females.

We examined the motor unit action potential amplitude versus recruitment threshold relationship (MUAPAMP-RT) as an indicator of MU-specific hypertrophy following high-intensity exercise training in females. Participants were assigned to either a high-intensity exercise (EX, n = 9) or control (CON, n = 18) condition and completed pre- (PRE) and post-testing (POST) during which maximal voluntary isometric leg extension strength (MVIT), vastus lateralis (VL) muscle cross sectional area (mCSA), whole leg skeletal muscle mass (SMMRL), and high-density surface EMG (HD-sEMG) signals were recorded from the VL during an isometric ramp contraction at 70% MVIT. The HD-sEMG signals were decomposed and yielded a MUAPAMP and an absolute (ABS; Nm) and normalized (NORM; %MVIC) RT for each MU. Individual MUAPAMP-RT slopes and intercepts were calculated for each subject. Changes in the pooled MUAPAMP-RT relationships for each group were also examined. Finally, relationships among individual changes in slopes of MUAPAMP-RT and individual changes in mCSA and SMMRL were examined. Training elicited increases in MVIT (+18%), mCSA (+12%), and mean and pooled slopes of MUAPAMP-RTNORM. The individual changes in slopes of both the MUAPAMP-RT relationships were moderately to strongly (r = 0.48-0.68) related to changes in mCSA and SMMRL. Eight-weeks of high-intensity exercise elicited increases in MUAPAMP-RT slope in females. Further, the observed change in slope was related to both VL mCSA and SMM of the tested leg. However, changes in slope for the MUAPAMP-RT relationship were more subdued when MUAPAMP was expressed relative to the absolute versus relative RT.

Resistance exercise attenuates postprandial metabolic responses to a high-fat meal similarly in younger and older men.

This study examined whether an acute bout of resistance exercise (RE) attenuated postprandial responses to a high fat meal (HFM) similarly in younger versus older adult men, and probed relationships among skeletal muscle mass (SMM), age, the metabolic load index (MLI) response, and the improvement in the MLI elicited by RE versus CON. Eleven younger (24 ±â€¯4y) and 9 older (61 ±â€¯5y) men completed RE or control (CON) the night prior to a HFM. Before and 1, 3, and 5 hours after the HFM, blood triglycerides (TG), glucose (GLU), MLI, and cholesterol concentrations were quantified. Following a 7 ±â€¯1-day washout period, participants returned and completed the opposite condition. Independent of age, TGs were 32.1 ±â€¯27.1 mg/dL and 52.7 ±â€¯26.8 mg/dL lower in RE than CON at 3 and 5 hours, respectively. MLI was also 24.3 to 56.9 mg/dL lower in RE than CON from 1 to 5 hours post-meal independent of age. The TG and MLI area under the curves (AUCs) were 15% to 31% lower in RE than CON. The GLU response was greater in the older than younger men at 1 to 5 hours post-meal. Moreover, the average GLU response was 5.6 ±â€¯2.5 mg/dL lower in RE versus CON and was inversely related to SMM across the sample (r = -0.615). However, age, volume, or SMM were not related to the MLIAUC, nor to the improvement elicited by RE. Therefore, although the older men displayed a greater postprandial glucose response than the younger men, RE attenuated the postprandial metabolic response to a HFM similarly in younger and older men.

Maximal contraction methods influence the magnitude and reliability of global electromyographic signal characteristics.

OBJECTIVE: The purpose was two-fold: (1) to examine differences in maximal voluntary isometric torque (MVIT) production, and electromyographic signal amplitude (EMGAMP) and mean power frequency (EMGMPF) values obtained during traditional (MVICTRAD), rapid (MVICRAPID), and ramp (MVICRAMP) maximal voluntary isometric contractions, and (2) to determine if there were differences in the reliability of MVIT, EMGAMP and EMGMPF among the three MVIC types. APPROACH: Twenty-two young males and females completed MVICTRAD, MVICRAPID, and MVICRAMP muscle actions on two separate visits separated by 48 h. During all MVICs, MVIT and EMGAMP and EMGMPF of the vastus lateralis (VL) and rectus femoris (RF) were quantified. MAIN RESULTS: MVIT was greater during MVICTRAD and MVICRAPID than during MVITRAMP (both p < 0.001). VL and RF EMGAMP were greater during MVICRAMP than during MVICRAPID (p = 0.02 and 0.004). For EMGMPF, there were no significant differences among MVIC types. Although all MVIC types generally resulted in reliable measurements of MVIT and EMGAMP, reliability was stronger for EMGMPF quantified during the MVICRAMP. SIGNIFICANCE: Investigators may choose MVIC type based on preference or equipment availability. However, investigators should note that MVICRAMP contractions will likely yield the greatest EMGAMP values and more reliable measurements of VL and RF EMGMPF.

The effects of vibration-induced altered stretch reflex sensitivity on maximal motor unit firing properties.

It is well known that muscle spindles have a monosynaptic, excitatory connection with α-motoneurons. However, the influence of muscle spindles on human motor unit behavior during maximal efforts remains untested. It has also been shown that muscle spindle function, as assessed by peripheral reflexes, can be systematically manipulated with muscle vibration. Therefore, the purpose of this study was to analyze the effects of brief and prolonged vibration on maximal motor unit firing properties. A crossover design was used, in which each of the 24 participants performed one to three maximal knee extensions under three separate conditions: 1) control, 2) brief vibration that was applied during the contraction, and 3) after prolonged vibration that was applied for ~20 min before the contraction. Multichannel EMG was recorded from the vastus lateralis during each contraction and was decomposed into its constituent motor unit action potential trains. Surprisingly, an approximate 9% reduction in maximal voluntary strength was observed not only after prolonged vibration but also during brief vibration. In addition, both vibration conditions had a large, significant effect on firing rates (a decrease in the rates) and a small to moderate, nonsignificant effect on recruitment thresholds (a small increase in the thresholds). Therefore, vibration had a detrimental influence on both maximal voluntary strength and motor unit firing properties, which we propose is due to altered function of the stretch reflex pathway. NEW & NOTEWORTHY We used vibration to alter muscle spindle function and examined the vibration's influence on maximal motor unit properties. We discovered that vibration had a detrimental influence on motor unit behavior and motor output by decreasing motor unit firing rates, increasing recruitment thresholds, which led to decreased maximal strength. We believe that understanding the role of muscle spindles during maximal contractions provides a deeper insight into motor control and sensorimotor integration.

Cross-education: effects of age on rapid and maximal voluntary contractile characteristics in males.

PURPOSE: The purpose of this study was to determine the effect of age on the cross-education of rapid and maximal contractile properties for the knee extensors. METHODS: Young (n = 10; age = 21.1 ± 1.7 years) and older (n = 10; age = 65.3 ± 8.3 years) males performed unilateral isokinetic resistance training (RT) of the knee extensors for 4 weeks. Maximal voluntary isokinetic (45° s-1 and 300° s-1) and isometric testing was conducted for the trained and untrained leg before and after RT. Peak torque (PT) and acceleration were obtained from isokinetic testing as well as torque at 30 ms (TQ30) and 100 ms (TQ100) from the 45° s-1 contraction. PT and rate of torque development were recorded from the isometric contractions. RESULTS: Independent of age, isometric PT (10.1%; p = 0.006) as well as PT and acceleration at 300° s-1 (6.7%; p = 0.008 and 4.0%; p = 0.016, respectively) increased in the untrained leg. At 45° s-1, acceleration was increased (3.6%; p = 0.021), but PT remained unchanged (p = 0.227). TQ100 increased similarly between groups (4.5%; p = 0.014), but TQ30 increased only in the older group (9.5%; p = 0.022). CONCLUSIONS: Cross-education of rapid and maximal contractile parameters can be achieved early during unilateral RT independent of age. These findings indicate the potential for particular unilateral RT protocols to be used for older adults in rehabilitative settings to offset disuse-related reductions in contractile function, which are most dramatic in this population.

Impact of Fatiguing, Submaximal High- vs. Low-Torque Isometric Exercise on Acute Muscle Swelling, and Echo Intensity in Resistance-Trained Men.

Muddle, TWD, Magrini, MA, Colquhoun, RJ, Luera, MJ, Tomko, PM, and Jenkins, NDM. Impact of fatiguing, submaximal high- vs. low-torque isometric exercise on acute muscle swelling, and echo intensity in resistance-trained men. J Strength Cond Res 33(4): 1007-1019, 2019-To evaluate the effects of repeated, fatiguing isometric knee extension contractions performed at high-torque (HT) vs. low-torque (LT) maximal voluntary isometric contraction (MVIC) on acute muscle swelling, and echo intensity (EI) of the rectus femoris (RF) and vastus lateralis (VL) muscles in resistance-trained males. Twenty-two resistance-trained men performed either HT (70% MVIC) or LT (30% MVIC) isometric contractions to fatigue on separate days. Before and after exercise, muscle cross-sectional area (mCSA) and EI of the RF and VL were assessed through ultrasound. Muscle cross-sectional area and EI (collapsed across muscle) increased similarly after HT (mean ± 95% confidence interval: mCSAΔ: 3.52 ± 0.52 cm; EIΔ: 4.58 ± 1.65 au) and LT (mCSAΔ: 3.61 ± 0.59 cm; EIΔ: 3.30 ± 1.36 au) exercise. No relationships between mCSAΔ and time to task failure (TTF), normalized MVIC, or the tension-time integral were observed during either HT or LT exercise. During both conditions, EIΔ was related to TTF (HT: r = 0.44; LT: r = 0.66) and normalized MVIC (HT: r = -0.60; LT: r = -0.57). These results suggest that acute muscle swelling and increased EI observed in response to intermittent, submaximal, fatiguing isometric exercise are similar for the RF and VL and are not dependent on the torque-level or tension-time integral when exercise is performed to failure. Factors such as the duration of time performing exercise and relative muscle strength may influence the magnitude of change in EI, but not acute muscle swelling, during intermittent fatiguing isometric exercise.

Age Does Not Attenuate Maximal Velocity Adaptations in the Ipsilateral and Contralateral Limbs During Unilateral Resistance Training.

This study examined the effects of unilateral resistance training (RT) on maximal velocity parameters in the ipsilateral and contralateral legs in young and older males. Young (n = 22; age = 21.55 ± 2.23 years) and older (n = 20; age = 65.10 ± 9.65 years) males were assigned to training or control groups. Unilateral isokinetic RT of the knee extensors was performed for 4 weeks. Peak velocity and acceleration were identified during a dynamic maximal voluntary contraction before (PRE), at Week 2 (MID), and after Week 4 (POST) of RT. Age-independent increases in peak velocity (1.5%) and acceleration (4.5%) were demonstrated at POST for the trained leg. For the untrained leg, acceleration increased (4.3%) at POST similarly between training groups. These findings provide evidence for the high degree of neuromuscular plasticity, regardless of age, during the early phase of RT, and the potential for cross education of acceleration.

Reliability and differences in quadriceps femoris muscle morphology using ultrasonography: The effects of body position and rest time.

INTRODUCTION: The purpose of this investigation was to: (1) to determine the reliability of rectus femoris muscle cross-sectional area and echo intensity obtained using panoramic ultrasound imaging during seated and supine lying positions before and after a 5-minute rest period and (2) to determine the influence of body position and rest period on the magnitude of rectus femoris muscle cross-sectional area and echo intensity measurements. METHODS: A total of 23 males and females (age = 21.5 ± 1.9 years) visited the laboratory on two separate occasions. During each visit, panoramic ultrasound images of the rectus femoris were obtained in both a seated and a supine position before (T1) and after a 5-minute (T2) rest period to quantify any potential changes in either muscle cross-sectional area and/or echo intensity. RESULTS: None of the muscle cross-sectional area or echo intensity measurements exhibited systematic variability, and the ICCs were 0.98-0.99 and 0.88-0.91, and the coefficients of variation were ≤ 3.9% and ≤ 8.2% for muscle cross-sectional area and echo intensity, respectively. Our results indicated that muscle cross-sectional area was greater in the seated than supine position, whereas echo intensity was greater in the supine position. Further, echo intensity increased in the seated position from T1 to T2. CONCLUSION: Both rectus femoris muscle cross-sectional area and echo intensity may be reliably measured in either a seated or supine lying position before or after a 5-minute rest period. Aside from echo intensity in the seated position, rest period had no influence on the magnitude of muscle cross-sectional area or echo intensity. Comparison of muscle cross-sectional area values that are obtained in different body positions is ill-advised.

The influence of input excitation on the inter- and intra-day reliability of the motor unit firing rate versus recruitment threshold relationship.

Decomposition of the surface electromyographic (sEMG) signal is commonly used to examine motor unit (MU) firing behavior. However, the intra- and inter-day reliability of these measurements has yet to be quantified or reported. This investigation 1) examined the effect of input excitation on the mean firing rate (MFR) vs. recruitment threshold (RT) relationship and 2) determined the inter- and intra-day reliability of the MFR vs. RT relationship at 30%, 50%, and 70% of maximum voluntary isometric strength (MVIC). Twenty-eight healthy males (23 ± 3 yr) completed two experimental visits, during which they performed MVIC testing and isometric ramp contractions at 30%, 50%, and 70% MVIC. sEMG signals were recorded from the vastus lateralis during the ramp contractions and decomposed to establish the MFR vs. RT relationship for the detected MUs. Intra- and inter-day reliability was then established for the slopes and y-intercepts of the MFR vs. RT relationship at each contraction intensity. All participants displayed significant MFR vs. RT relationships ( r range: -0.662 to -0.999; P ≤ 0.001-0.006). Intra- and inter-day intraclass correlation coefficients (ICCs) ranged from 0.766-0.824 and 0.867-0.919 for the slopes and from 0.780-0.915 and 0.804-0.927 for the y-intercepts, respectively. Furthermore, the slope coefficient was significantly greater at 70% than at 30% MVIC, and the y-intercepts increased with increasing contraction intensities. Changes in input excitation to the MU pool alter the magnitude, but not the reliability, of the slopes and y-intercepts of the MFR vs. RT relationship. NEW & NOTEWORTHY The firing behavior of the motor unit (MU) pool is often characterized using the mean firing rate vs. recruitment threshold relationship of the active MUs. Although this relationship has been widely used, this is the first study to report the effects of input excitation (contraction intensity) on the intra- and inter-day reliability of this relationship. The criteria used for MU analysis and the model utilized in this study allow for generalization to outside investigators and laboratories.

Genetic variant in the ß2 -adrenergic receptor (Arg16Gly) influences fat-free mass, muscle strength and motor unit behaviour in young men.

NEW FINDINGS: What is the central question of this study? Does a common genetic variant in the ß2 -adrenergic receptor (ß2 -AR) have effects on skeletal muscle function in young, healthy men? What is the main finding and its importance? This study provides preliminary evidence that ß2 -AR Arg16Gly genotype has a significant effect on fat-free mass, muscle strength and motor unit behaviour in recreationally trained men. These data might have important clinical and exercise-related implications. For example, ß2 -AR (rs1042713) genotype might influence the responsiveness of skeletal muscle to clinical or exercise-based interventions or ß-AR agonist treatment. ABSTRACT: This study explored whether the ß2 -adrenergic receptor (ß2 -AR) single nucleotide polymorphism at amino acid 16 (Arg16Gly) has functional effects on skeletal muscle mass, torque production and motor unit behaviour in young, healthy men. Twenty-eight recreationally active men (mean ± SD 23.1 ± 1.3 years of age) were genotyped for Arg16Gly polymorphisms of ß2 -AR as arginine homozygous (ArgArg; n = 5), glycine homozygous (GlyGly; n = 11) or arginine-glycine heterozygous (ArgGly; n = 12). The participants then completed body composition testing, assessments of leg extensor size and echo intensity, and evoked and voluntary isometric leg-extension muscle actions. During the evoked muscle actions, peak twitch torque, peak rate of torque development and peak relaxation rate were assessed. During the voluntary muscle actions, maximal voluntary isometric (MVIC) strength was assessed, and surface EMG signals were obtained during submaximal isometric muscle actions and later decomposed to examine motor unit firing behaviour. Fat-free mass and MVIC strength were greater (P = 0.004, d = 1.74 and P = 0.026, d = 1.10, respectively) in those expressing the GlyGly versus ArgArg allele. The slope of the mean firing rate versus recruitment threshold relationship was more negative in the GlyGly than the ArgArg allele carriers (P = 0.012, d = 1.68) at 50% MVIC, but was less negative in GlyGly and ArgGly versus ArgArg allele carriers (P = 0.013 and 0.016, respectively; d = 1.34 and 1.20, respectively) at 70% MVIC. These data provide preliminary evidence that ß2 -AR Arg16Gly genotype has a significant effect on fat-free mass, muscle strength and motor unit behaviour in humans.

Global electromyographic signal characteristics depend on maximal isometric contraction method in the knee extensors.

OBJECTIVE: To determine if maximal isometric contraction (MVIC) method (i.e., ramp (MVICRAMP) versus traditional MVIC) influences (1) maximal voluntary isometric torque (MVIT) production of the knee extensors, (2) electromyographic signal amplitude (EMGAMP), and (3) EMG mean power frequency (EMGMPF) of the rectus femoris and vastus lateralis in moderately-to highly-activated subjects. We hypothesized that EMGAMP would be greater during the MVICRAMP than MVIC muscle contractions, but that there would be no difference in MVIT. APPROACH: Twenty-five males (23.4 ±â€¯3.4 y; % voluntary activation = 93.9 ±â€¯5.1%) visited the laboratory and completed MVICRAMPs and MVICs. During all contractions, leg extensor torque and sEMG signals from the vastus lateralis (VL) and rectus femoris (RF) were recorded. MAIN RESULTS: There was no significant difference in the MVIT produced (p = 0.65) or in EMGMPF (p = 0.052) during MVICRAMP versus MVIC. However, EMGAMP was 18.1% higher during the MVICRAMP than MVIC (p = 0.004). SIGNIFICANCE: Maximal isometric muscle contraction method significantly influenced EMGAMP, and had a moderate effect on EMGMPF (d = 0.49). Investigators who utilize MVICs to determine maximal EMG signal amplitude and frequency to normalize their EMG signals should be aware of these differences.

Can Squat Jump Performance Differentiate Starters vs. Nonstarters in Division I Female Soccer Players?

Magrini, MA, Colquhoun, RJ, Sellers, JH, Conchola, EC, Hester, GM, Thiele, RM, Pope, ZK, and Smith, DB. Can squat jump performance differentiate starters vs. nonstarters in division I female soccer players? J Strength Cond Res 32(8): 2348-2355, 2018-Although soccer is predominately an endurance sport, high velocity movements may be an important indicator of athletic success. The purpose of this investigation was to establish whether squat jumps (SJs) can differentiate starters from nonstarters with a female collegiate division I soccer team. Eighteen female division I soccer athletes were separated into 2 groups: 9 starters (age: 19.5 ± 1.0; mass = 64.8 ± 11.5 kg; height = 167.5 ± 7.7 cm; games started = 18.2 ± 4.7; and minutes played = 1633.8 ± 478.2 minutes) and 9 nonstarters (age: 19.4 ± 1.4 years; mass = 63.3 ± 4.2 kg; height = 164.7 ± 6.8 cm; games started 0.7 ± 1.3; and minutes played 158.2 ± 269.3 minutes). Each athlete performed 3 maximal SJs at a starting knee angle of 110° without arm swing. Each participant's SJ height, mean power (MP), peak power (PP), mean velocity (MV), and peak velocity (PV) were measured during each attempt by a linear position transducer. No statistically significant differences (p ≥ 0.05) in MP and PP between the starters and nonstarters were observed. However, starters performed significantly better than nonstarters in SJ height (p = 0.002), MV (p = 0.025), and PV (p = 0.015). In addition, SJ height was strongly correlated with MV (r = 0.628) and PV (r = 0.647). These findings suggest that SJ height, MV, and PV may be important variables for discriminating differences between starters and nonstarters in division I female soccer athletes and a strong indicator of explosive performance.

Effects of fatiguing, submaximal high- versus low-torque isometric exercise on motor unit recruitment and firing behavior.

The purpose of this investigation was to evaluate the effects of repeated, high- (HT: 70% MVIC) versus low-torque (LT: 30% MVIC) isometric exercise performed to failure on motor unit (MU) recruitment and firing behavior of the vastus lateralis. Eighteen resistance-trained males (23.1 ± 3.8 years) completed familiarization, followed by separate experimental sessions in which they completed either HT or LT exercise to failure in random order. LT exercise resulted in a greater time to task failure and a more dramatic decline in the muscle's force capacity, but the total work completed was similar for HT and LT exercise. An examination of the firing trains from 4670 MUs recorded during exercise revealed that firing rates generally increased during HT and LT exercise, but were higher during HT than LT exercise. Furthermore, recruitment thresholds (RT) did not significantly change during HT exercise, whereas the RT of the smallest MUs increased and the RT for the moderate to large MUs decreased during LT exercise. Both HT and LT exercise resulted in the recruitment of additional higher threshold MUs in order to maintain torque production. However, throughout exercise, HT required the recruitment of larger MUs than did LT exercise. In a few cases, however, MUs were recruited by individuals during LT exercise that were similar in size and original (pre) RT to those detected during HT exercise. Thus, the ability to achieve full MU recruitment during LT exercise may be dependent on the subject. Consequently, our data emphasize the task and subject dependency of muscle fatigue.

Muscle phenotype is related to motor unit behavior of the vastus lateralis during maximal isometric contractions.

Previous investigations have reported a relationship between skeletal muscle phenotype and motor unit (MU) firing parameters during submaximal contractions. The purpose of the current investigation, however, was to examine the relationships between motor unit firing behavior during a maximal voluntary contraction, Myosin Heavy Chain (MHC) isoform content, and various molecular neuromuscular targets of the vastus lateralis (VL) muscle in resistance-trained men. Ten resistance-trained males completed a trapezoidal ramp contraction up to 100% of their maximal voluntary isometric strength (MVIC). Surface electromyography was recorded from the VL using a multichannel electrode array and decomposed to examine the firing characteristics of individual MUs. A skeletal muscle biopsy of the VL was also collected from each subject. Regression analyses were performed to identify relationships between type II fiber area and the slopes and/or intercepts of the mean firing rate (FRMEAN ) versus recruitment threshold (RT), max firing rate (FRMAX ) versus RT, and RT versus MU action potential amplitude (MUAPPP ) relationships. There were significant inverse relationships between type II fiber area and the y-intercept of the FR versus RT relationship (P < 0.05). Additionally, strong relationships (r > 0.5) were found between type II fiber area and FRMEAN versus RT slope and RT versus MUAPPP slope and intercept. These data further support the hypothesis that skeletal muscle phenotype is related to MU behavior during isometric contraction. However, our data, in concert with previous investigations, may suggest that these relationships are influenced by the intensity of the contraction.

Role of Rotational Kinematics in Minimizing Elbow Varus Torques for Professional Versus High School Pitchers.

BACKGROUND: Elbow injury rates among baseball pitchers are rapidly rising. However, this increase has been most dramatic among high school (HS) pitchers. PURPOSE: To examine pitch velocity and the kinetic and kinematic characteristics of HS versus professional (PRO) pitchers to identify potential differences that may play a role in the increased risk of ulnar collateral ligament injury in youth pitchers. STUDY DESIGN: Controlled laboratory study. METHODS: A total of 37 HS (mean ± SD: age, 16 ± 1 years) and 40 PRO (age, 21 ± 2 years) baseball pitchers completed maximal-effort baseball pitches during a single testing session, from which pitch velocity (PV), absolute and normalized elbow varus torque (EVTA and EVTN, respectively) during arm cocking and at maximum shoulder external rotation (MER), and 8 other elbow and shoulder torques or forces and rotational kinematics of the pelvis and trunk were analyzed, recorded, and compared. RESULTS: PV was greater in PRO than HS athletes; EVTA was greater in PRO than HS athletes during arm cocking and at MER; but EVTN was similar during arm cocking and greater in HS than PRO athletes at MER. In PRO athletes, PV was not related to EVTA during arm cocking or MER (r = 0.01-0.05). Furthermore, in PRO athletes, EVTA during arm cocking and at MER were inversely related to upper trunk rotation at hand separation and foot contact and to pelvis rotation at elbow extension (r = -0.30 to -0.33). In contrast, in HS athletes, PV was strongly related to EVTA during arm cocking and MER (r = 0.76-0.77). Furthermore, in HS athletes, PV and EVTA during arm cocking and at MER were moderately or strongly related to the other elbow and shoulder torques and forces (r = 0.424-0.991), and EVTA was not related to upper trunk rotation or pelvis rotation throughout the throwing motion (r = -0.16 to 0.15). CONCLUSION: The kinetic and rotational kinematic differences observed between PRO and HS pitchers in this study may help explain the greater performance of PRO pitchers while allowing them to minimize EVT during pitching. HS pitchers, however, do not appear to be as capable of utilizing the forces generated by rotation of their trunk and pelvis to aid in pitching, and those who throw the hardest generate the greatest forces at the shoulder and elbow. As a result, they experience higher EVTs relative to their body size, which may place them at an increased risk of injury. CLINICAL RELEVANCE: HS pitchers throw harder primarily by generating larger forces in the arm and shoulder. Thus, owing to the relative physical immaturity of HS versus PRO pitchers, these factors may place them at an increased risk of injury. Coaches may first wish to focus on improving the rotational kinematics of HS pitchers rather than first focusing on achieving greater pitch velocities.

Training Volume, Not Frequency, Indicative of Maximal Strength Adaptations to Resistance Training.

Colquhoun, RJ, Gai, CM, Aguilar, D, Bove, D, Dolan, J, Vargas, A, Couvillion, K, Jenkins, NDM, and Campbell, BI. Training volume, not frequency, indicative of maximal strength adaptations to resistance training. J Strength Cond Res 32(5): 1207-1213, 2018-To compare the effects of a high versus a moderate training frequency on maximal strength and body composition. Twenty-eight young, healthy resistance-trained men were randomly assigned to either: 3× per week (3×; n = 16) or 6× per week (6×; n = 12). Dependent variables (DVs) assessed at baseline and after the 6-week training intervention included: squat 1 repetition maximum (SQ1RM), bench press 1RM (BP1RM), deadlift 1RM (DL1RM), powerlifting total (PLT), Wilk's coefficient (WC), fat-free mass (FFM), and fat mass. Data for each DV were analyzed using a 2 × 2 between-within factorial repeated-measures analysis of variance. There was a main effect for time (p < 0.001) for SQ1RM (3×: +16.8 kg; 6×: +16.7 kg), BP1RM (3×: +7.8 kg; 6×: +8.8 kg), DL1RM (3×: +19 kg; 6×: +21 kg), PLT (3×: +43.6 kg; 6×: +46.5 kg), WC (3×: +27; 6×: +27.1), and FFM (3×: +1.7 kg; 6×: +2.6 kg). There were no group × time interactions or main effects for group. The primary finding was that 6 weeks of resistance training led to significant increases in maximal strength and FFM. In addition, it seems that increased training frequency does not lead to additional strength improvements when volume and intensity are equated. High-frequency (6× per week) resistance training does not seem to offer additional strength and hypertrophy benefits over lower frequency (3× per week) when volume and intensity are equated. Coaches and practitioners can therefore expect similar increases in strength and lean body mass with both 3 and 6 weekly sessions.