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Bioorg Med Chem Lett ; 16(13): 3362-6, 2006 Jul 01.
Article in English | MEDLINE | ID: mdl-16650762

ABSTRACT

A series of 1,3-disubstituted cyclohexylmethyl urea and amide derivatives were synthesized as motilin receptor antagonists. Starting from known motilin antagonists, 1a and 1b, the cyclopentene scaffold was replaced and the four recognition elements optimized to arrive at a potent novel series.


Subject(s)
Amides/chemical synthesis , Amides/pharmacology , Cyclohexanes/chemistry , Receptors, Gastrointestinal Hormone/antagonists & inhibitors , Receptors, Neuropeptide/antagonists & inhibitors , Urea/chemical synthesis , Urea/pharmacology , Amides/chemistry , Cell Line , Drug Evaluation, Preclinical , Humans , Molecular Structure , Stereoisomerism , Structure-Activity Relationship , Urea/chemistry
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