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2.
Int Arch Allergy Appl Immunol ; 48(6): 756-63, 1975.
Article in English | MEDLINE | ID: mdl-806536

ABSTRACT

Serum sickness followed the administration of anti-lymphocyte globulin to a patient with multiple sclerosis. In addition to other characteristic features of this syndrome, there was hypocomplementemia and transient renal dysfunction similar to that observed in the 'one-shot' experimental model of serum sickness. Cryoglobulinemia was transiently demonstrable at the height of the inflammatory response. Analysis of the purified cryoprecipitate revealed the presence of human IgG and IgA, and, in addition, equine IgG. This demonstration of a well-defined exagenous antigen in the cryoprecipitate provides further support for the immune complex nature of mixed cryoglobulins.


Subject(s)
Immunoglobulin A/analysis , Immunoglobulin G/analysis , Serum Sickness/immunology , Adult , Animals , Antilymphocyte Serum/therapeutic use , Complement C3/analysis , Cryoglobulins/analysis , Diphenhydramine/therapeutic use , Hemolysis , Horses/immunology , Humans , Immune Sera , Immunodiffusion , Immunoglobulin M/analysis , Immunotherapy , Male , Multiple Sclerosis/therapy , Muscle Cramp/drug therapy , Proteinuria/etiology , Rabbits/immunology , Rheumatoid Factor/analysis , Skin Transplantation , Transplantation, Homologous
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