ABSTRACT
The isolation of multicaulisin, a new Diels-Alder type adduct from Morus multicaulis roots is reported.
Subject(s)
Flavonoids/chemistry , Plant Extracts/chemistry , Plants, Medicinal , Humans , Plant RootsABSTRACT
11-Deoxyfistularin-3 (1), a new bromotyrosine derivative, was isolated among other known compounds such as fistularin-3 (2), aerothionin (3), and 11-oxoaerothionin (4) from the Caribbean sponge Aplysinafistularis (Aplysinellidae). The structure of 1 was determined by spectroscopic analysis and showed in vitro activity against the human breast carcinoma cell line MCF-7.
Subject(s)
Antineoplastic Agents/isolation & purification , Porifera/chemistry , Tyrosine/analogs & derivatives , Animals , Antineoplastic Agents/chemistry , Antineoplastic Agents/pharmacology , Humans , Molecular Structure , Spectrum Analysis , Tumor Cells, Cultured , Tyrosine/chemistry , Tyrosine/isolation & purification , Tyrosine/pharmacologyABSTRACT
Illimaquinone, a sponge metabolite that disrupts the Golgi complex in mammalian cells, stopped proliferation and induced morphological and ultrastructural changes in promastigotes of L. mexicana. Radioactive labeling of proteins demonstrates an increased excretion function and diminution of membrane acid phosphatase activity, due probably to the vesiculation of the Golgi complex and alteration of the cell protein sorting mechanism. The result indicated that illimaquinone could be useful for the study of intracellular traffic in Trypanosomatidae.
Subject(s)
Enzyme Inhibitors/pharmacology , Leishmania mexicana/drug effects , Leishmania mexicana/growth & development , Quinones/pharmacology , Acid Phosphatase/metabolism , Animals , Cell Membrane/enzymology , Dose-Response Relationship, Drug , Golgi Apparatus/enzymology , Leishmania mexicana/ultrastructureABSTRACT
The Palauan sponge Axinyssa aplysimoides contained (3S*,5R*,6R*,9R*)-3-isocyano-1(10)-cadinene[2],(3S*,5R*,6R*, 9R*)-3-formamido-1(10)-cadinene[3], and (E)-(4-hydroxystyryl)trimethylammonium chloride [6], together with the known diterpenes (-)-neoverrucosan-5beta-ol[4] and (+)-homoverrucosan-5beta-ol[5].
