ABSTRACT
PURPOSE: To describe a case of bilateral acute iris transillumination (BAIT)-like syndrome following intracameral moxifloxacin injection after cataract surgery. METHODS: A case report. RESULTS: We report a case of unilateral acute iris transillumination and distorted pupil in a 53-year-old male who underwent uneventful cataract extraction with intracameral moxifloxacin. CONCLUSION: BAIT-like syndrome may be a rare side effect of intracameral moxifloxacin.
Subject(s)
Iris , Transillumination , Anti-Bacterial Agents/adverse effects , Humans , Male , Middle Aged , Moxifloxacin/adverse effects , SyndromeABSTRACT
Purpose: To report the case of a drug-induced uveitis during the treatment of a metastatic cutaneous melanoma.Case report: A 75-year-old female treated with Dabrafenib and Trametinib due to a cutaneous melanoma stage IV presented with blurriness in both eyes. The examination revealed bilateral intraocular signs of inflammation, and fundoscopy showed bilateral changes at the posterior pole, such as chorioretinal folds and Neurosensory Retinal Detachment (NRD). Due to a worsening of Visual Acuity (VA) and persistence of intraocular inflammation in spite of topical prednisolone acetate treatment, the therapy with Dabrafenib + Trametinib was interrupted, after having been administered for 4 months, and replaced by Nivolumab. Fundus abnormalities and intraocular inflammation improved, but VA remained low due to the presence of an epiretinal membrane in the right eye. Then, a decreasing course of prednisolone eye drops was introduced for one more month and finally interrupted without the cessation of Nivolumab.Conclusion: Drug-induced uveitis has been increasing in the last few years due to the development of new biological agents for treatment of different types of tumours. The management of these adverse events should be handled in collaboration with oncologists and ophthalmologists and must be individualised and based on the risk-benefit balance. A case report of an uveitis and subsequent development of an epiretinal membrane during the treatment with Dabrafenib, Trametinib and subsequent Nivolumab for a metastatic cutaneous melanoma is reported here, in order to note the importance of an adequate follow-up of patients treated with these drugs.
Subject(s)
Antineoplastic Agents/adverse effects , Drug-Related Side Effects and Adverse Reactions/etiology , Epiretinal Membrane/chemically induced , Liver Neoplasms/drug therapy , Melanoma/drug therapy , Skin Neoplasms/drug therapy , Uveitis/chemically induced , Aged , Drug-Related Side Effects and Adverse Reactions/diagnosis , Epiretinal Membrane/diagnostic imaging , Epiretinal Membrane/drug therapy , Female , Glucocorticoids/therapeutic use , Humans , Imidazoles/adverse effects , Liver Neoplasms/secondary , Lymphatic Metastasis , Melanoma/secondary , Neoplasm Staging , Oximes/adverse effects , Prednisolone/therapeutic use , Pyridones/adverse effects , Pyrimidinones/adverse effects , Skin Neoplasms/pathology , Tomography, Optical Coherence , Uveitis/diagnosis , Uveitis/drug therapyABSTRACT
Purpose: To report a case of endogenous endophthalmitis caused by Haemophilus influenzae in an immunocompetent host.Case report: A 13-year-old male presented with pain, blurriness, and decreased Visual Acuity (VA) of Hand Motion in his right eye. Slit-lamp examination revealed hypopyon. Fundoscopy showed vitritis, vasculitis, and retinal infiltrates. Echography revealed vitreous condensations. Empirical treatment with intravitreal Ganciclovir, oral Valacyclovir, and Dexamethasone was initiated with no improvement. Vitreous culture revealed Haemophilus influenzae growth. Then, intravenous Ciprofloxacin and Cefotaxime and intravitreal Ceftazidime were administered with gradual improvement. Lensectomy with Pars Plana Vitrectomy and intraocular tamponade was performed. Nevertheless, the visual outcome was poor.Conclusion: Pediatric endogenous bacterial endophthalmitis is a rare but potentially devastating infection which is often misdiagnosed. Moreover, we want to highlight the importance of an adequate clinical suspicion in cases of H. influenzae to prevent the serious complications seen in this report.
Subject(s)
Endophthalmitis/microbiology , Eye Infections, Bacterial/microbiology , Haemophilus Infections/microbiology , Haemophilus influenzae/isolation & purification , Adolescent , Anti-Bacterial Agents/therapeutic use , Cataract Extraction , Cefotaxime/therapeutic use , Ceftazidime/therapeutic use , Ciprofloxacin/therapeutic use , Drug Therapy, Combination , Endophthalmitis/diagnosis , Endophthalmitis/drug therapy , Endotamponade , Eye Infections, Bacterial/diagnosis , Eye Infections, Bacterial/drug therapy , Haemophilus Infections/diagnosis , Haemophilus Infections/drug therapy , Humans , Immunocompromised Host , Infusions, Intravenous , Intravitreal Injections , Male , Slit Lamp Microscopy , Visual Acuity/physiology , Vitreous Body/microbiologyABSTRACT
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