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2.
J Med Virol ; 86(6): 954-6, 2014 Jun.
Article in English | MEDLINE | ID: mdl-24610550

ABSTRACT

The discovery of autochthonous hepatitis E in industrialized countries associated to genotype 3 has changed substantially the understanding about hepatitis E virus (HEV) circulation. In these countries transmission has been associated to the consumption and direct contact to swine, a well-known reservoir for HEV. More animal reservoirs for HEV might exist since antibodies to HEV have been detected in other animal species, such as dogs and cats. Given the intimate contact between these pets and humans, the potential zoonotic HEV transmission from dogs and cats deserves to be explored. To address this issue, 493 sera from pet veterinarians (373) and matched general population (120) were tested for the presence of anti-HEV IgG using a commercial ELISA. Antibodies to HEV were found in 9.9% veterinarians and 13.3% general population. No statistically significant difference was found between these two groups showing that pet veterinarians have no increased risk to hepatitis E compared to the general population.


Subject(s)
Hepatitis E/epidemiology , Occupational Exposure , Pets , Veterinarians , Adult , Animals , Cats , Dogs , Enzyme-Linked Immunosorbent Assay , Female , Hepatitis Antibodies/blood , Humans , Immunoglobulin G/blood , Male , Middle Aged , Risk Assessment , Seroepidemiologic Studies , Young Adult
3.
J Med Virol ; 85(8): 1377-8, 2013 Aug.
Article in English | MEDLINE | ID: mdl-23722441

ABSTRACT

The high mortality of pregnant women is one of the main features of hepatitis E virus (HEV) infection in endemic countries. With the emergence of genotype 3 HEV in industrialized countries, attention should be given to pregnant women from these regions since the effect of genotype 3 HEV in pregnancy is not yet known. In this study, archived sera dating from 1993 from mothers with no history of traveling to HEV endemic countries and their newborns were tested for anti-HEV IgG antibodies. Four of the 12 maternal sera were positive for IgG anti-HEV, indicating exposure to this virus. Their newborns were also positive, showing higher anti-HEV IgG levels. Overall, these findings demonstrate not only an efficient transplacental transport of anti-HEV IgG, but also circulation of autochthonous HEV in Portugal in the early 1990s.


Subject(s)
Hepatitis Antibodies/blood , Hepatitis E virus/immunology , Hepatitis E/epidemiology , Hepatitis E/transmission , Infectious Disease Transmission, Vertical , Adolescent , Adult , Female , Humans , Immunoglobulin G/blood , Infant, Newborn , Mothers , Portugal/epidemiology , Pregnancy , Young Adult
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