Understanding adverse drug reactions in older adults through drug-drug interactions.

AIMS: The aims of this study are to evaluate prevalence and characteristics of adverse drug reactions (ADRs) and to evaluate the potential contribution of specific medications, therapeutic categories and drug-drug interactions (DDIs) in older adults. METHODS: All ADR reporting forms of persons aged 65+ years collected by the pharmacovigilance of one of the main hospitals in Italy during 2013 were evaluated. DDIs were analysed by a computerized prescription system (INTERCheck) and based on the interactions' database managed by the Istituto di Ricerche Farmacologiche Mario Negri. DDIs were classified according to their clinical relevance as contraindicated, major, and moderate. RESULTS: Amongst all the ADR reporting forms (n=1014) collected during 2013, 343 affected older adults. The most frequent ADRs were: haemorrhages (n=122, 35.5%), allergic reactions (n=56, 16.3%), and elevated International Normalized Ratio (INR>6, n=54, 15.7%). The specific medications that contributed to ADRs were warfarin (42.5%), acenocumarol (9%), and allopurinol (8.5%); while the therapeutic categories were haematological agents (67%) and proton pump inhibitors (13%). A total of 912 DDIs were found; one third of them were contraindicated or major and 31.5% of them potentially contributed to ADRs; of these, the most frequent were: warfarin and heparin (contraindicated, n=5); warfarin and a statin (major, n=38); warfarin and a proton pump inhibitor (moderate, n=40). At least one DDI contributed to 66 haemorrhages out of 122 (54%) and to 41 elevated INR out of 54 (76%). CONCLUSION: DDIs significantly contribute to the onset of ADRs in older adults and intervention programmes, e.g., the employment of a computerized system, may reduce the burden of iatrogenic illnesses in the elderly.

[Percutaneous tracheostomy: technological development]. / Tracheotomia percutanea. Sviluppo tecnologico.

PDT based on Seldinger's technique is gaining wide acceptance in ICU patients, but the procedure has undergone various modifications during the past thirty years. The ten most known procedures and the target of their innovating content are briefly examined. The incidence of complications desumed from the literature, wide in some cases and limited or absent in others, is also considered. In many cases, the technological modifications of original procedures had two fundamental objectives: to increase it's safety and to reduce the operator-depencence of the procedure. According to the review of the literature (and our experience too) the increasing interest for percutaneous tracheostomy is the justified conclusion of the technological development of some dilatative techniques. With an appropriate training and the continuous endoscopic guidance, it is possible today to perform PDT in critically ill patients of ICU with a very low total complication rate. Even if the comparison between different techniques is not rich enough on prospective randomized studies, the global low rate of hemorrhage complications, of wound infection and of poor cosmetic result are surely demonstrated and probably related to the small skin incision and the tight fitness between tissues and the tracheostomy tube.

[Enteral feeding in the treatment of severe anorexia nervosa]. / La nutrizione enterale nel trattamento della grave anoressia nervosa.

A programme of integrated enteral nutrition treatment is proposed for severe cases of anorexia nervosa. Such treatment seems better to satisfy patients' requirements and is closer to normal physiological nutrition. Treatment techniques are described and the results discussed, while the advantages of this therapy over all other methods used until now are underlined.