Demonstration of event position reconstruction based on diffusion in the NEXT-white detector.

Noble element time projection chambers are a leading technology for rare event detection in physics, such as for dark matter and neutrinoless double beta decay searches. Time projection chambers typically assign event position in the drift direction using the relative timing of prompt scintillation and delayed charge collection signals, allowing for reconstruction of an absolute position in the drift direction. In this paper, alternate methods for assigning event drift distance via quantification of electron diffusion in a pure high pressure xenon gas time projection chamber are explored. Data from the NEXT-White detector demonstrate the ability to achieve good position assignment accuracy for both high- and low-energy events. Using point-like energy deposits from 83mKr calibration electron captures (E∼45 keV), the position of origin of low-energy events is determined to 2 cm precision with bias <1mm. A convolutional neural network approach is then used to quantify diffusion for longer tracks (E≥1.5 MeV), from radiogenic electrons, yielding a precision of 3 cm on the event barycenter. The precision achieved with these methods indicates the feasibility energy calibrations of better than 1% FWHM at Qßß in pure xenon, as well as the potential for event fiducialization in large future detectors using an alternate method that does not rely on primary scintillation.

Grado de consecución de los objetivos lipídicos a largo plazo en una cohorte de pacientes con síndrome coronario agudo en práctica clínica real / Achievement of long-term lipid targets in a cohort of patients with acute coronary syndrome in real-world clinical practice

Introduction and objectives According to the recent European epidemiological studies, the degree of lipid control in patients with very high vascular risk is suboptimal. This study analyzes the epidemiological characteristics, cardiovascular risk factors, lipid profile, recurrence, and degree of achievement of long-term lipid targets, according to the ESC/EAS Guidelines, in a cohort of patients with acute coronary syndrome (ACS) in a real-world clinical practice setting. Methods This work is a retrospective cohort study of patients diagnosed with ACS admitted to the Coronary Unit of a tertiary hospital from January 1, 2012 to December 31, 2015 and followed-up on until March 2022. Results A total of 826 patients were studied. During the follow-up period, greater prescribing of combined lipid-lowering therapy was observed, mainly high- and moderate-intensity statins and ezetimibe. At 24 months after the ACS, 33.6% of living patients had LDL levels <70 mg/dl and 9.3% had LDL levels <55 mg/dl. At the end of the follow-up (101 [88–111] months), the corresponding figures were 54.5% and 21.1%. Some 22.1% of patients had a recurrent coronary event and only 24.6% achieved an LDL level <55 mg/dl. Conclusions Achievement of the LDL targets recommended by the ESC/EAS guidelines is suboptimal in patients with ACS, both at two years and in the long-term (7–10 years), especially in patients with recurrent ACS (AU)

Introducción y objetivos Según los recientes estudios epidemiológicos europeos, el grado de control lipídico de los pacientes de muy alto riesgo vascular es subóptimo. En este estudio se han analizado las características epidemiológicas, los factores de riesgo cardiovascular, el perfil lipídico, la recurrencia y el grado de consecución de los objetivos lipídicos a largo plazo, según las Guías ESC/EAS, en una cohorte de pacientes con síndrome coronario agudo (SCA), en condiciones de práctica clínica real. Métodos Estudio de cohorte retrospectivo de los pacientes con diagnóstico de SCA ingresados en la unidad coronaria de un hospital de tercer nivel, entre el 1 de enero de 2012 y el 31 de diciembre de 2015, y seguidos hasta marzo de 2022. Resultados Se estudiaron 826 pacientes. Durante el periodo de seguimiento se observó una mayor prescripción de terapia hipolipemiante combinada, principalmente estatinas de alta y moderada intensidad y ezetimibe. A los 24 meses del SCA, un 33,6% de los pacientes vivos tenían un LDL < 70 mg/dl y en un 9,3% los niveles eran < 55 mg/dl. Al final del seguimiento (101 [88–111] meses), las correspondientes cifras eran del 54,5 y 21,1%. Un 22,1% de los pacientes presentaron un evento coronario recurrente, y solamente un 24,6% de ellos alcanzaron un nivel de LDL < 55 mg/dl. Conclusiones El cumplimiento de los objetivos recomendados por las Guías ESC/EAS en pacientes con SCA, es subóptimo, tanto a los 2 años como a largo plazo (7-10 años) desde el evento, y en especial en los pacientes con SCA recurrente (AU)

Achievement of long-term lipid targets in a cohort of patients with acute coronary syndrome in real-world clinical practice.

INTRODUCTION AND OBJECTIVES: According to the recent European epidemiological studies, the degree of lipid control in patients with very high vascular risk is suboptimal. This study analyzes the epidemiological characteristics, cardiovascular risk factors, lipid profile, recurrence, and degree of achievement of long-term lipid targets, according to the ESC/EAS Guidelines, in a cohort of patients with acute coronary syndrome (ACS) in a real-world clinical practice setting. METHODS: This work is a retrospective cohort study of patients diagnosed with ACS admitted to the Coronary Unit of a tertiary hospital from January 1, 2012 to December 31, 2015 and followed-up on until March 2022. RESULTS: A total of 826 patients were studied. During the follow-up period, greater prescribing of combined lipid-lowering therapy was observed, mainly high- and moderate-intensity statins and ezetimibe. At 24 months after the ACS, 33.6% of living patients had LDL levels <70 mg/dl and 9.3% had LDL levels <55 mg/dl. At the end of the follow-up (101 [88-111] months), the corresponding figures were 54.5% and 21.1%. Some 22.1% of patients had a recurrent coronary event and only 24.6% achieved an LDL level <55 mg/dl. CONCLUSIONS: Achievement of the LDL targets recommended by the ESC/EAS guidelines is suboptimal in patients with ACS, both at two years and in the long-term (7-10 years), especially in patients with recurrent ACS.

Update on the utility of en face optical coherence tomography in the assessment of vitreoretinal diseases.

En face optical coherence tomography (EF-OCT) is a rapid, non-invasive, high-resolution imaging technique that has evolved in recent years to be a routine examination for the assessment and follow-up of various vitreoretinal diseases. With the introduction of swept-source OCT (SS-OCT), which can achieve up to 100,000 A-scans per second and better-quality imaging of deeper structures using a longer wavelength (1050nm), EF-OCT reconstruction can produce high-resolution frontal images of the retina and choroid (C-Scans) that give an overview of disease extent. These images allow a more accurate study of vitreoretinal interface pathologies such as epiretinal membranes, macular holes, and vitreomacular traction. They also provide key information in the study of various retinal vascular diseases and the differential diagnosis of cystic macular edema. EF-OCT provides valuable information about the severity of vitreoretinal interface alterations and precisely assesses the choriocapillaris and choroidal vasculature in pachychoroid disorders. Finally, this technique provides valuable information about atrophic and neovascular age-related macular degeneration and various uveitic entities. This review aims to describe the current clinical applications of EF-OCT in various vitreoretinal diseases as well as the latest findings and future perspectives.

Cross-tissue immune cell analysis reveals tissue-specific features in humans.

Despite their crucial role in health and disease, our knowledge of immune cells within human tissues remains limited. We surveyed the immune compartment of 16 tissues from 12 adult donors by single-cell RNA sequencing and VDJ sequencing generating a dataset of ~360,000 cells. To systematically resolve immune cell heterogeneity across tissues, we developed CellTypist, a machine learning tool for rapid and precise cell type annotation. Using this approach, combined with detailed curation, we determined the tissue distribution of finely phenotyped immune cell types, revealing hitherto unappreciated tissue-specific features and clonal architecture of T and B cells. Our multitissue approach lays the foundation for identifying highly resolved immune cell types by leveraging a common reference dataset, tissue-integrated expression analysis, and antigen receptor sequencing.

Tisseel® versus Hemopatch® for dural sealing in neurosurgery. A prospective study in a tertiary center.

BACKGROUND: Dural repair is a potential source of complications in neurosurgery. We make a comparison in pseudomeningocele and CSF leak incidence with the sealants Tisseel® and Hemopatch®. METHODS: We collected 147 patients from September 2017 to December 2018 in a prospective observational study. Inclusion criteria were adult patients with an intradural cranial or spinal surgery whose dura was closed with a fibrin sealant. Primary endpoints were the incidence of pseudo meningocele and CSF leak. Secondary endpoints were the surgical-site infection, epidural hematoma, and the influence of previous surgery. RESULTS: In 65 and 82 patients Tisseel® and Hemopatch® were used as sealants respectively. The incidence of CSF leak presented a significant statistical relation with the use of Tisseel® in a univariate and multivariate analysis. Infratentorial surgery presented a higher incidence of pseudomeningocele and CSF leak, but the approach used was not a significant factor in multivariate analysis. Patients who were operated previously had a higher risk present a postoperative complication. CONCLUSIONS: The incidence of pseudomeningocele and CSF leak was higher with Tisseel® compared with Hemopatch® with a statistic significant relation in case of CSF fistulae. The procedure done may be a confusion factor in our study. There was no report of adverse effects or a higher incidence of complications. However, it is recommended to plan randomized trials with larger samples to get stronger evidence.

The protective effect of extra-virgin olive oil in the experimental model of multiple sclerosis in the rat.

This study has evaluated the effect of EVOO (Extra-Virgin olive oil), OA (oleic acid) and HT (hydroxytyrosol) in an induced model of MS through experimental autoimmune encephalomyelitis (EAE).Dark Agouti 2-month old rats (25 males) were divided into five groups: (i) control group, (ii) EAE group, (iii) EAE+EVOO, (iv) EAE+HT, and (v) EAE+OA. At 65 days, the animals were sacrificed and the glutathione redox system and bacterial lipopolysaccharide (LPS) and LPS-binding protein (LBP) products of the microbiota in brain, spinal cord, and blood were evaluated.Gastric administration of EVOO, OA, and HT reduced the degree of lipid and protein oxidation, and increased glutathione peroxidase, making it a diet-based mechanism for enhancing protection against oxidative damage. In addition, it reduced the levels of LPS and LBP, which appeared as being increased in the EAE correlated with the oxidative stress produced by the disease.

[The role of the cognitive reserve in the cognitive recovery of patients who have suffered a severe addiction to substances]. / Papel de la reserva cognitiva en la recuperacion cognitiva de pacientes que han sufrido una adiccion grave a sustancias.

INTRODUCTION: Cognitive reserve has been shown to be a prognostic variable in cognitive recovery after brain damage. Few studies have addressed its role in the cognitive status after a sustained period of substance addiction. AIM: To analyse the modulating role of cognitive reserve in the relation between withdrawal time and the cognitive status of patients with severe substance addiction. PATIENTS AND METHODS: A total of 26 patients recovering from severe substance addiction were assessed using a neuropsychological assessment protocol and cognitive reserve questionnaires. Exploratory factor analysis is used to define the variables and linear regression analysis is employed to view the predictive relations. RESULTS: Three cognitive functioning factors are obtained: processing integrity, inhibitory control and verbal memory, as well as an overall reserve factor. In the regression models, predictive relations are found only in a model of a direct relation between withdrawal and verbal memory, and in a model of an independent relation between cognitive reserve and withdrawal time and verbal memory, but not in the modulation relationship or in other relations in the rest of the factors. CONCLUSION: The article discusses the role of the cognitive reserve as a mediator in the cognitive status of patients in a period of withdrawal after a serious addiction to substances. A relationship with memory is shown, but no modulation of the role of withdrawal time on that cognitive status is detected.

TITLE: Papel de la reserva cognitiva en la recuperacion cognitiva de pacientes que han sufrido una adiccion grave a sustancias.Introduccion. La reserva cognitiva resulta ser una variable de pronostico en la recuperacion cognitiva tras un daño cerebral. Pocos estudios han abordado su papel en el estado cognitivo tras un periodo sostenido de adiccion a sustancias. Objetivo. Analizar el papel modulador de la reserva cognitiva sobre la relacion entre el tiempo de abstinencia y el estado cognitivo de los pacientes con adiccion grave a sustancias. Pacientes y metodos. Se valora a un total de 26 pacientes en recuperacion tras una adiccion grave a sustancias con un protocolo de evaluacion neuropsicologica y cuestionarios de reserva cognitiva. Se emplea el analisis factorial exploratorio para conformar las variables y el analisis de regresion lineal para ver las relaciones predictivas. Resultados. Se obtienen tres factores de funcionamiento cognitivo: integridad de procesamiento, control inhibitorio y memoria verbal, asi como un factor global de reserva. En los modelos de regresion, solo se encuentran relaciones predictivas en un modelo de relacion directa entre la abstinencia y la memoria verbal, y en un modelo de relacion independiente entre la reserva cognitiva y el tiempo de abstinencia con la memoria verbal, pero no en la relacion de modulacion, ni en otras relaciones en el resto de los factores. Conclusion. Se debate el papel de la reserva cognitiva como mediadora en el estado cognitivo en los pacientes en periodo de abstinencia tras una adiccion grave a sustancias: muestra una relacion con la memoria, pero no una modulacion del papel del tiempo de abstinencia sobre ese estado cognitivo.

Síndrome de Susac. A propósito de las encefalitis autoinmunes / Susac's syndrome. A case of autoimmune encephalitis

No disponible

Demonstration of Single-Barium-Ion Sensitivity for Neutrinoless Double-Beta Decay Using Single-Molecule Fluorescence Imaging.

A new method to tag the barium daughter in the double-beta decay of ^{136}Xe is reported. Using the technique of single molecule fluorescent imaging (SMFI), individual barium dication (Ba^{++}) resolution at a transparent scanning surface is demonstrated. A single-step photobleach confirms the single ion interpretation. Individual ions are localized with superresolution (∼2 nm), and detected with a statistical significance of 12.9σ over backgrounds. This lays the foundation for a new and potentially background-free neutrinoless double-beta decay technology, based on SMFI coupled to high pressure xenon gas time projection chambers.

Effect of tyrosine kinase inhibitors on the glucose levels in diabetic and nondiabetic patients.

CONTEXT: Tyrosine kinase inhibitors (TKIs) are used in different types of cancers due to their good profile of adverse reactions and their convenience in the oral administration. Some studies describe that certain TKIs are associated with changes in the glycemic profile of the patients. AIMS: This study aims to determine if treatment with ITK affects to serum glucose levels in clinical practice. SETTINGS AND DESIGN: A retrospective study was carried out in 136 episodes (112 patients treated with sorafenib, sunitinib, imatinib, dasatinib, or nilotinib). SUBJECTS AND METHODS: The serum glucose levels were analyzed before treatment and after months 1, 2, 3, 6, 9, and 12 of treatment. STATISTICAL ANALYSIS USED: Statistical analysis was completed with SPSS version 20 for Windows. RESULTS: There were significant differences in the serum glucose levels before treatment between diabetic and nondiabetic patients, but not between the average blood glucose readings before treatment and the average of the subsequent readings, once their treatment had begun. CONCLUSIONS: The results of this study do not reproduce the results of the literature since changes in the serum glucose levels have not been found in this sample of patients.

Apoyo a la autonomía, creencias implícitas de habilidad y metas de logro en jugadoras de baloncesto en formación / Apoio à autonomia, crenças implícitas de capacidade e objetivos de conquista em jogadores de basquete em treinamento / Autonomy support, implicit beliefs of ability and achievement goals in basketball players in training

El objetivo principal del estudio fue analizar las relaciones entre el apoyo a la autonomía de entrenadores, compañeras, padres y madres, las creencias implícitas de habilidad y las metas de logro 2 x 2 de un grupo de jugadoras de baloncesto. La muestra estuvo compuesta por 57 jugadoras de baloncesto de la cantera de un equipo de baloncesto de Huelva. Estas jugadoras tenían entre los 10 y los 17 años (M = 13.02; DT = 1.90). Se midió el clima de apoyo a la autonomía del entrenador, de las compañeras, de padres y madres percibido por las jugadoras, las creencias implícitas de habilidad y las metas de logro 2x2. Los resultados del análisis de regresión lineal muestran que el clima de apoyo a la autonomía generado por el entrenador predice la meta de aproximación al rendimiento y la habilidad incremental. A su vez, la habilidad incremental predice las metas de aproximación y evitación a la maestría. Esto pone de manifiesto la importancia de generar climas de soporte a la autonomía de las jugadoras de baloncesto durante su formación, ya que adoptarán metas de logro más adaptativas (AU)

The main objective of the study was to analyze the relationship between support for the autonomy of coaches, teammates, parents, implicit ability beliefs and goals achievement 2 x 2 of a group of female basketball players. The sample consisted of 57 basketball players from the quarry of a basketball team of Huelva. These players were between 10 and 17 years (M = 13.02, SD = 1.90). The climate of support for the autonomy of the coach, the companions of parents perceived by the players, the implicit beliefs of skill and achievement goals 2x2 was measured. The results of linear regression analysis show that the climate of autonomy support generated by the coach predicts the performance approach goal and incremental skill. In turn, the ability predicts incremental approach goals and avoidance to mastery. Tis highlights the importance of creating climates support the autonomy of basketball players during their training, as they adopt more adaptive goals achievement (AU)

O principal objetivo do estudo foi analisar a relação entre o apoio para a autonomia dos treinadores, companheiros, pais, crenças capacidade implícita e metas conquista 2 x 2 de um grupo de jogadores de basquete. A amostra consistiu de 57 jogadores de basquete da pedreira de um time de basquete de Huelva. Estes jogadores tinham entre 10 e 17 anos (M = 13.02, SD = 1.90). o clima de apoio para a autonomia do treinador, os companheiros dos pais percebidos pelos jogadores, as crenças implícitas de habilidade e realização metas 2x2 foi medido. Os resultados da análise de regressão linear mostram que o clima de apoio autonomia gerado pelo treinador prevê a meta abordagem de desempenho e habilidade incremental. Por sua vez, a capacidade prevê metas abordagem incremental e evasão para a maestria. Isso destaca a importância da criação de climas apoiar a autonomia dos jogadores de basquete durante a sua formação, em que adotam as mais adaptáveis cumprimento de metas (AU)

Method for quantifying NSAIDs and clofibric acid in aqueous samples, lumpfish (Cyclopterus lumpus) roe, and zebrafish (Danio rerio) eleutheroembryos and evaluation of their bioconcentration in zebrafish eleutheroembryos.

Pharmaceuticals such as nonsteroidal anti-inflammatory drugs (NSAIDs) and lipid regulators are being repeatedly detected at low concentrations (pg · mL-1-ng · mL-1) in the environment. A large fraction of these compounds are ionizable. Ionized compounds show different physico-chemical properties and environmental behavior in comparison to their neutral analogs; as a consequence, the quantification methods currently available, based on the neutral molecules, might not be suitable to detect the corresponding ionized compounds. To overcome this problem, we developed a specific analytical method to quantify NSAIDs and lipid regulators (i.e., ibuprofen, diclofenac, naproxen, and clofibric acid) and their ionized compounds. This method is based on three steps: (1) the extraction of the organic compounds with an organic solvent assisted with an ultrasonic probe, (2) the cleaning of the extracts with a dispersive SPE with C18, and (3) the determination of the chemical compounds by GC-MS (prior derivatization of the analytes). We demonstrated that the proposed method can successfully quantify the pharmaceuticals and their ionized compounds in aqueous samples, lumpfish eggs, and zebrafish eleutheroembryos. Additionally, it allows the extraction and the cleanup of extracts from small samples (0.010 g of wet weight in pools of 20 larvae) and complex matrixes (due to high lipid content) and can be used as a basis for bioaccumulation assays performed with zebrafish eleutheroembryos in alternative to OECD test 305.

Influence of barbed suture in laparoscopic radical prostatectomy. / Influencia de la sutura barbada en la prostatectomía radical laparoscópica.

OBJECTIVES: To determine the influence of barbed suture in laparoscopic radical prostatectomy. METHODS: A retrospective study of 150 patients who underwent laparoscopic radical prostatectomy was carried out by our department. The patients were divided in two groups according to the kind of suture used during the vesicourethral anastomosis: conventional 3-0 absorbable multifilament running suture (group 1) and bidirectional barbed suture (Quill®) (group 2). Operating time, postoperatory urinary fistula, hospital stay and catheter duration were analyzed in both groups. RESULTS: After the analysis of all the preoperative variables, such as age, PSA, prostate volume, Gleason and stage on biopsy, no statistically significant differences were found in both groups. Operating time was significantly shorter in Group 2 (169±43 min vs 215±45 min, p=0.00). Statistically significant differences were found regarding postoperative urinary fistula rate, hospital stay and urethral catheterization duration, favourable to Group 2. CONCLUSIONS: The use of bidirectional barbed suture (Quill®) for vesicourethral anastomosis in laparoscopic radical prostatectomy, when compared with the conventional suture, shortens surgical time, reduces urinary fistula rate, catheter duration and hospital stay, as the anastomosis is easily performed and prevents leakage.

Influencia de la sutura barbada en la prostatectomía radical laparoscópica / Influence of barbed suture in laparoscopic radical prostatectomy

OBJETIVO: El objetivo es determinar la influencia de la sutura barbada en la prostatectomía radical laparoscópica. MÉTODOS: Realizamos un estudio retrospectivo de 150 pacientes intervenidos en nuestro servicio mediante prostatectomía radical laparoscópica. Comparamos dos grupos en función de la sutura utilizada para la realización de la anastomosis vésico-uretral: sutura convencional continua de 3-0 reabsorbible multifilamento (Grupo 1) y sutura barbada bidireccional (Quill®) (Grupo 2). Analizamos los siguientes parámetros: tiempo operatorio, incidencia de fístula urinaria en el postoperatorio, estancia hospitalaria y días de sonda urinaria. RESULTADOS: Se analizaron todas las variables preoperatorias tales como edad, PSA, volumen prostático, Gleason y estadío en la biopsia, no observándose diferencias significativas entre los dos grupos. El tiempo quirúrgico fue significativamente menor para el Grupo 2, con 169±43 minutos, frente a 215±45 minutos del Grupo 1 (p = 0.00). Observamos diferencias estadísticamente significativas en la tasa de fístula urinaria, la estancia postoperatoria y el tiempo de cateterización uretral, a favor del Grupo 2. CONCLUSIONES: El uso de la sutura barbada bidireccional (Quill®) en la anastomosis vésico-uretral de la prostatectomía radical laparoscópica, cuando la comparamos con la sutura convencional, acorta el tiempo quirúrgico y disminuye la incidencia de fístula urinaria, los días de sonda y la estancia hospitalaria, ya que facilita la realización anastomosis y mejora la estanqueidad de la misma

OBJECTIVES: To determine the influence of barbed suture in laparoscopic radical prostatectomy. METHODS: A retrospective study of 150 patients who underwent laparoscopic radical prostatectomy was carried out by our department. The patients were divided in two groups according to the kind of suture used during the vesicourethral anastomosis: conventional 3-0 absorbable multifilament running suture (Group 1) and bidirectional barbed suture (Quill®) (Group 2). Operating time, postoperative urinary fistula, hospital stay and urinary catheter duration were analysed in both groups. RESULTS: After the analysis of all the preoperative variables, such as age, PSA, prostate volume, Gleason and stage on biopsy, no statistically significant differences were found in both groups. Operating time was significantly shorter in Group 2 (169±43 min vs 215±45 min, p = 0.00). Statistically significant differences were found regarding postoperative urinary fistula rate, hospital stay and urethral catheterization duration, favourable to Group 2. CONCLUSIONS: The use of bidirectional barbed suture (Quill®) for vesicourethral anastomosis in laparoscopic radical prostatectomy, when compared with the conventional suture, shortens surgical time, reduces urinary fistula rate, catheter duration and hospital stay, as the anastomosis is easily performed and prevents leakage

Relación entre la actividad física y parámetros hemodinámicos en adultos / Relationship between physical activity and hemodynamic parameters in adults

Objetivo: Analizar la relación entre la actividad física, medida con acelerómetro, con índices de aumento central y periférico, y el grosor intima media (GIM) de carótida en adultos. Métodos: Se analizó a 263 pacientes incluidos en el estudio EVIDENT. La actividad física se evaluó con el acelerómetro Actigraph GT3X (counts/min) durante 7 días. La ecografía carotídea se utilizó para medir el grosor de íntima media de la carótida. El Sistema Sphygmo Cor se utilizó para medir el índice de aumento central y periférico (CAIx y PAIx). Resultados: Edad media 55,85 ± 12,21 años; 59,30% mujeres, índice de masa corporal 26,7 y presión arterial 120/77 mmHg. La actividad física media fue 244,37 counts/min. La media de tiempo dedicado a la actividad vigorosa o muy vigorosa fue 2,63 ± 10,26 min/día. Se observó una correlación inversa entre la actividad física y el PAIx (r = -0,179; p < 0,01), y entre el tiempo dedicado a la actividad vigorosa o muy vigorosa con el GIM (r = -0,174; p < 0,01), el CAIx (r = -0,217; p < 0,01) y el PAIx (r = -0,324; p < 0,01). Después de ajustar por diferentes factores de confusión, en el análisis de regresión múltiple se mantiene la asociación entre CAIx y la actividad física evaluada tanto con counts/min (p < 0,01) como con el tiempo dedicado a la actividad vigorosa o muy vigorosa (p < 0,01). Conclusiones: Los resultados indican que tanto la actividad física como el tiempo dedicado a la actividad vigorosa o muy vigorosa se asocian con el índice de aumento central en adultos

Objectives: To analyze the relationship between physical activity, as assessed by accelerometer, with central and peripheral augmentation index and carotid intima media thickness (IMT) in adults. Methods: This study analyzed 263 subjects who were included in the EVIDENT study. Physical activity was assessed during 7 days using the ActigraphGT3X accelerometer (counts/min). Carotid ultrasound was used to measure carotid IMT. The Sphygmo Cor System was used to measure central and peripheral augmentation index (CAIx and PAIx). Results: Mean age 55.85 ± 12 years; 59.30% female; 26.7 body mass index and blood pressure 120/77 mmHg. Mean physician activity counts/min was 244.37 and 2.63 ± 10.26 min/day of vigorous or very vigorous activity. Physical activity showed an inverse correlation with PAIx (r = -0.179; P<.01) and vigorous activity day time with IMT(r = -0.174; P<.01), CAIx (r = -0.217; P<.01) and PAIx (r =-0.324; P<.01). After adjusting for confounding factors in the multiple regression analysis, the inverse association of CAIx with counts/min and the time spent in vigorous/very vigorous activity was maintained. Conclusion: The results suggest that both physical activity and time spent in vigorous or vigorous activity are associated with the central augmentation index in adults