ABSTRACT
Intraspinal metallomas are rare. The authors present a case after implantation of two titanium threaded interbody cages at the L4L5 level, without posterior instrumentation. To their knowledge this is the first case due to intervertebral cages. The lack of additional instrumentation had probably allowed the cages to make contact. Subsequently, friction generated wear debris, which led to the formation of a granuloma, responsible for compression of the dural sac. Intraspinal metallosis should be kept in mind as an infrequent cause of delayed neurological symptoms after spinal surgery with metallic instrumentation.
Subject(s)
Granuloma, Foreign-Body/etiology , Internal Fixators/adverse effects , Spinal Fusion/adverse effects , Spinal Fusion/instrumentation , Spinal Stenosis/etiology , Decompression, Surgical , Granuloma, Foreign-Body/complications , Humans , Magnetic Resonance Imaging , Male , Middle Aged , Titanium , Tomography, X-Ray ComputedABSTRACT
BACKGROUND AND OBJECTIVE: The aim of this study was to determine the prognostic value of molecular markers (proteins) of different paths of lung cancer development in patients with non small cell lung carcinoma (NSCLC) in initial stages. MATERIAL AND METHOD: Observational, cohort study in patients with NSCLC that was initially treated surgically in our hospital between October 1993 and September 1997. Thirty-two proteins were selected. The study consisted of the elaboration of tissue arrays with samples from resected tumour, using a semiquantitative immunohistochemical study. A prognosis analysis was done with the expression of each protein and calculation of the overall 5-year survival rate. The Wilcoxon-Gehan and Log-Rank tests were used for statistical comparisons, with p<.05 being considered to indicate a significant result. RESULTS: One hundred and forty six patients were studied. The overall 5-year survival rate was 37.7%. From 32 proteins studied, three were statistically associated with overall 5-year survival rate. RB protein expression in resected NSCLC was a positive prognostic factor (P=.01). P27 (P=.03) and Ki67 (P=.04) expression in resected NSCLC were negative prognostic factors. There was no protein with prognostic value in epidermoid tumours. CONCLUSIONS: We found three proteins with long-term prognostic value in the long-term in the general population and five adenocarcinoma prognostic proteins in our study of resected non-small cell lung cancer (NSCLC). In the future, genetic-molecular factors should be included along with anatomical (TNM staging) and clinical factors in a multidimensional lung cancer staging.
Subject(s)
Biomarkers, Tumor/analysis , Carcinoma, Non-Small-Cell Lung/chemistry , Carcinoma, Non-Small-Cell Lung/mortality , Lung Neoplasms/chemistry , Lung Neoplasms/mortality , Neoplasm Proteins/analysis , Aged , Carcinoma, Non-Small-Cell Lung/metabolism , Cohort Studies , Female , Humans , Lung Neoplasms/metabolism , Male , Middle Aged , Neoplasm Proteins/biosynthesis , Prognosis , Survival RateABSTRACT
Fundamentos y objetivo: Estudio pronóstico de marcadores moleculares implicados en la carcinogénesis del carcinoma broncogénico (CB), en pacientes con CB no microcítico (CBNM) resecado en estadios iniciales. Material y método: Estudio observacional y de cohorte de pacientes con CBNM en estadios iniciales intervenidos en el Hospital 12 de Octubre de Madrid entre el 1 de octubre de 1993 y el 30 de septiembre de 1997. Se estudiaron 32 proteínas con un análisis inmunohistoquímico semicuantitativo. Se realizó un análisis de la expresión de cada proteína en relación con la supervivencia a 5 años mediante las pruebas de Wilcoxon-Gehan y log rank, aceptando como significativo un valor de p<0,05.ResultadosEl número final de pacientes incluidos fue de 146. La supervivencia a 5 años fue del 37,7%. De las 32 proteínas, hemos encontrado tres con significado pronóstico a 5 años: la expresión de RB, asociada a mejor pronóstico (p=0,01), y la expresión de p27 (p=0,03) y Ki67 (p=0,04), asociadas a peor pronóstico. En el análisis según histología no hay ninguna proteína con valor pronóstico en CB epidermoide, mientras que hay cinco en adenocarcinomas. Conclusiones: En esta serie de CBNM resecado hay 3 marcadores moleculares con valor pronóstico a largo plazo en la población general y cinco en adenocarcinomas. Probablemente, en el futuro los factores moleculares se unan a los de extensión anatómica y clínicos en una clasificación pronóstica multidimensional en CB (AU)
Background and objective: The aim of this study was to determine the prognostic value of molecular markers (proteins) of different paths of lung cancer development in patients with non small cell lung carcinoma (NSCLC) in initial stages. Material and method: Observational, cohort study in patients with NSCLC that was initially treated surgically in our hospital between October 1993 and September 1997. Thirty-two proteins were selected. The study consisted of the elaboration of tissue arrays with samples from resected tumour, using a semiquantitative immunohistochemical study. A prognosis analysis was done with the expression of each protein and calculation of the overall 5-year survival rate. The Wilcoxon-Gehan and Log-Rank tests were used for statistical comparisons, with p<.05 being considered to indicate a significant result. Results: One hundred and forty six patients were studied. The overall 5-year survival rate was 37.7%. From 32 proteins studied, three were statistically associated with overall 5-year survival rate. RB protein expression in resected NSCLC was a positive prognostic factor (P=.01). P27 (P=.03) and Ki67 (P=.04) expression in resected NSCLC were negative prognostic factors. There was no protein with prognostic value in epidermoid tumours. Conclusions: We found three proteins with long-term prognostic value in the long-term in the general population and five adenocarcinoma prognostic proteins in our study of resected non-small cell lung cancer (NSCLC). In the future, genetic-molecular factors should be included along with anatomical (TNM staging) and clinical factors in a multidimensional lung cancer staging (AU)
Subject(s)
Humans , Carcinoma, Bronchogenic/pathology , /analysis , Bronchial Neoplasms/pathology , Immunohistochemistry , Gene Products, rex/analysis , Retinoblastoma Protein/analysis , SurvivorshipABSTRACT
Chronic obstructive pulmonary disease (COPD) is an independent risk factor to develop lung cancer but there are no different functional clusters of biomarkers between patients with non-small cell lung cancer (NSCLC) with or without COPD. To analyse protein expression, in order to find out whether samples of resected NSCLC from patients with COPD present a different molecular expression. Observational, cohort, concurrent study with sampling since treatment of disease in patients with NSCLC in initial stages (pIA-pIIB) treated surgically in our hospital between October 1993 and September 1997. The study consisted of the elaboration of tissue arrays with samples from resected tumor, using immunohistochemistry as a study method. Univariate analysis and logistic regression analysis were performed in order to determine molecular markers that showed a differential expression in NSCLC of the patients with COPD. We studied thirty-two proteins in 146 patients. 30% of the patients had COPD. Univariate analysis in patients with COPD showed one molecular marker to be overexpressed and five molecular markers to be underexpressed. Multivariate analysis in patients with COPD identified membranous beta-Catenin as a differential biomarker, which displayed an underexpression, with an Odds Ratio (95% Confidence Interval) of 0.26 (0.07-1.01). A significant lowest expression of membranous beta-catenin was detected in NSCLC of the patients with COPD.
Subject(s)
Biomarkers, Tumor/analysis , Biomarkers, Tumor/biosynthesis , Carcinoma, Non-Small-Cell Lung/metabolism , Lung Neoplasms/metabolism , Pulmonary Disease, Chronic Obstructive/metabolism , Aged , Carcinoma, Non-Small-Cell Lung/complications , Caspase 3/analysis , Caspase 3/biosynthesis , Cell Cycle Proteins/analysis , Cell Cycle Proteins/biosynthesis , Cyclooxygenase 2/analysis , Cyclooxygenase 2/biosynthesis , Down-Regulation , Fas Ligand Protein/analysis , Fas Ligand Protein/biosynthesis , Humans , Lung Neoplasms/complications , Male , Membrane Proteins/analysis , Membrane Proteins/biosynthesis , Middle Aged , Nuclear Proteins/analysis , Nuclear Proteins/biosynthesis , Pulmonary Disease, Chronic Obstructive/complications , Risk Factors , Tissue Array Analysis , Up-Regulation , beta Catenin/analysis , beta Catenin/biosynthesisABSTRACT
No disponible
Subject(s)
Humans , Chordoma/pathology , Bone Neoplasms/pathology , Notochord/pathology , Biopsy, Fine-Needle/methodsABSTRACT
No disponible
Subject(s)
Humans , Chordoma/pathology , Bone Neoplasms/pathology , Notochord/pathology , Biopsy, Fine-Needle/methodsABSTRACT
No disponible
No disponible
Subject(s)
Male , Adult , Humans , Carcinoma, Bronchogenic/pathology , Biomarkers, Tumor/analysis , Lung Neoplasms/pathology , Carcinoma, Squamous Cell/pathologyABSTRACT
OBJECTIVES: Primary adenocarcinoma of the female urethra is a rare malignancy. We report two cases and a review of the latest articles focused on classification and treatment of this kind of neoplasm. METHODS: We present two females diagnosed of urethral adenocarcinoma, describing clinic and pathological features, diagnosis and treatment. CONCLUSIONS: Female urethral adenocarcinoma is an uncommon neoplasm with a heterogeneous histogenesis. The distal urethral carcinoma is more amenable to treatment, and the prognosis is better than that of proximal or entire urethral carcinoma, which is often associated with extensive local invasion and metastasis.
Subject(s)
Adenocarcinoma , Urethral Neoplasms , Adenocarcinoma/diagnosis , Adenocarcinoma/therapy , Aged , Female , Humans , Middle Aged , Urethral Neoplasms/diagnosis , Urethral Neoplasms/therapyABSTRACT
OBJETIVOS: Ante una entidad infrecuentecomo es el adenocarcinoma de uretra femenina, deseamosaportar dos casos y revisar las últimas publicaciones.Además queremos recordar de forma breve, la clasificacióny el tratamiento de este tipo de tumor.MÉTODOS/RESULTADOS: Presentamos dos mujeres diagnosticadasde adenocarcinoma de uretra, describiendo lapresentación clínica, métodos diagnósticos empleados,tratamiento utilizado y características histológicas.CONCLUSIONES: Los adenocarcinomas de uretra femeninoconstituyen un tipo tumoral infrecuente, originados apartir de diferentes estructuras. Los carcinomas de uretradistal tienen mejor pronóstico por su diagnóstico precoz,al contrario que los de uretra proximal y los que afectan atoda la uretra, que suelen ser de diagnóstico tardío, enestadio avanzado
OBJECTIVES: Primary adenocarcinoma ;;of the female urethra is a rare malignancy. We report two ;;cases and a review of the latest articles focused on ;;classification and treatment of this kind of neoplasm. ;;METHODS: We present two females diagnosed of urethral ;;adenocarcinoma, describing clinic and pathological ;;features, diagnosis and treatment. ;;CONCLUSIONS: Female urethral adenocarcinoma is an ;;uncommon neoplasm with a heterogeneous histogenesis. ;;The distal urethral carcinoma is more amenable to ;;treatment, and the prognosis is better than that of proximal ;;or entire urethral carcinoma, which is often associated with ;;extensive local invasion and metastasis
