ABSTRACT
HLA-A*02:653 differs from A*02:01:01:01 by a C to T substitution in exon 2.
Subject(s)
Alleles , HLA-A Antigens/genetics , Base Sequence , Exons/genetics , Female , Humans , ItalyABSTRACT
The novel allele HLA-A*03:275N differs from HLA-A*03:01:01:01 by 1 nucleotide substitutions in exon 2.
Subject(s)
Exons , HLA-A3 Antigen/genetics , Mutation, Missense , HumansABSTRACT
The novel allele DQA1*01:15N differs from DQA1*01:03:01:01 by 1 nucleotide substitutions in exon 2.
Subject(s)
Alleles , HLA-DQ Antigens/genetics , Humans , ItalyABSTRACT
HLA-C*07:555 differs from C*07:01:01:01 by a C to G substitution in exon 2.
Subject(s)
Alleles , Exons , HLA-C Antigens/genetics , Polymorphism, Single Nucleotide , Unrelated Donors , Amino Acid Substitution , Base Sequence , Codon/chemistry , Gene Expression , Genotype , HLA-C Antigens/immunology , Hematopoietic Stem Cell Transplantation , Histocompatibility Testing , Humans , Polymerase Chain Reaction , Sequence Alignment , Sequence Analysis, DNAABSTRACT
The new allele, officially named HLA DRB1*14:129, differs from HLA DRB1*14:54 in exon 2.
Subject(s)
Alleles , HLA-DRB1 Chains/genetics , Point Mutation , Base Sequence , Exons , HLA-DRB1 Chains/immunology , Histocompatibility Testing , Humans , Molecular Sequence Data , Stem Cell Transplantation , Tissue DonorsABSTRACT
The new allele differs from HLA-DPB1*23:01 in exon 3.
Subject(s)
HLA-DP beta-Chains/genetics , Polymorphism, Single Nucleotide , Alleles , Base Sequence , Chromosomes, Human, Pair 6 , Exons , HLA-DP beta-Chains/immunology , Hematopoietic Stem Cell Transplantation , Histocompatibility Testing , Humans , Molecular Sequence Data , Sequence Alignment , Sequence Analysis, DNA , Tissue DonorsABSTRACT
The new allele shows one nucleotide change from C*07:02:01:01 at 351 nt from C to A, resulting in an amino acid change at codon 93 of exon 3 from H to Q.
Subject(s)
Alleles , Exons/genetics , HLA-C Antigens/genetics , Mutation/genetics , Amino Acid Sequence , DNA Probes, HLA/genetics , Hematopoietic Stem Cell Transplantation , Histocompatibility Testing , Humans , Italy , Molecular Sequence Data , Polymorphism, Single Nucleotide , Sequence Analysis, DNA , Tissue DonorsABSTRACT
Human leukocyte antigen (HLA) class I sequence-based typing (SBT) for hematopoietic unrelated donor searching in an Italian Caucasian patient showed the presence of a novel HLA-A allele defined as A*31:48. HLA-A*31:48 has one nucleotide change from A*31:01:02 at nt 727 from C to T, resulting in an amino acid change at codon 219 of exon 4 from Arg to Trp.
