ABSTRACT
Objective: The purpose of this study was to estimate the minimum clinically important differences (MCIDs) in the Minnesota Living with Heart Failure questionnaire (MLHFQ), which targeted patients with heart failure treated with integrated Chinese and Western medicine, as a means of helping doctors and patients judge the effectiveness of intervention. Methods: A total of 194 patients with chronic heart failure were recruited from three general hospitals in Beijing. Anchor-based and distribution-based approaches were used to estimate MCID. The anchor was SF-36 item 2 (HT, Health Transition), and the calculation methods included the mean change method, receiver operating characteristic (ROC) curve analysis, and linear regression model. For the distribution-based approaches, 0.2, 0.5, and 0.8 standardized response mean (SRM) values and standard error of measurement (SEM) value of 1 were used. Results: The correlation coefficients of the MLHFQ scale information and HT were 0.346-0.583. Different MCIDs were obtained by the mean change method, ROC curve, and linear regression model. The minimum MCID in the physical domain, emotional domain, and total scores were 3.6, 2.0, and 7.4, respectively; the maximum estimates were 9.5, 2.5, and 13.0, respectively; and the average estimates were 5.7, 2.2, and 10.0, respectively. The average estimates were close to the result of the 0.5 SRM or 1 SEM. Conclusion: We established MCIDs in the MLHFQ using anchor-based and distribution-based approaches. It was recommended to round the average estimates of anchor-based approaches up to the nearest whole number for the MCIDs of the MLHFQ physical domain, emotional domain, and total scores. The results were 6.0, 2.0, and 10.0, respectively.
ABSTRACT
PURPOSE: Mapping the Minnesota Living with Heart Failure Questionnaire (MLHFQ) to SF-6Dv2 in Chinese patients with chronic heart failure, and to obtain the health utility value for health economic assessment. METHODS: Four statistical algorithms, including ordinary least square method (OLS), Tobit model, robust MM estimator (MM) and censored least absolute deviations (CLAD), were used to establish the alternative model. Models were validated by using a tenfold cross-validation technique. The mean absolute error (MAE) and root mean square error (RMSE) were used to evaluate the prediction performance of the model. The Spearman correlation coefficient and Intraclass Correlation Coefficients (ICC) were used to examine the relationship between the predicted and observed SF-6Dv2 values. RESULTS: A total of 195 patients with chronic heart failure were recruited from 3 general hospitals in Beijing. The MLHFQ summary score and domain scores of the study sample were negatively correlated with SF-6Dv2 health utility value. The OLS regression model established based on the MLHFQ domain scores was the optimal fitting model and the predicted value was highly positively correlated with the observed value. CONCLUSION: The MLHFQ can be mapped to SF-6Dv2 by OLS, which can be used for health economic assessment of cardiovascular diseases such as chronic heart failure.
Subject(s)
Heart Failure , Quality of Life , China , Chronic Disease , Humans , Least-Squares Analysis , Surveys and QuestionnairesABSTRACT
OBJECTIVE: To investigate the association of Sp110 gene SNP with tuberculosis occurrence of Chongqing Han people. METHODS: Design Use the case-control study design, and collect risk factors of tuberculosis by questionnaires. Use multiple methods to detect rs1135791C/T, rs722555A/G, 5'-UTR rs11679983A/G, rs28930679C/T, rs9061A/G, rs1063154G/T, rs1047254A/G, rs3948464C/T points SNP polymorphism. Use SAS software to perform significance test. And use MDR software to analyze the cross action of SNP points related to tuberculosis susceptibility. RESULTS: (1) the frequencies of Sp110 gene rs1135791CT genotype, rs722555 GG genotype, rs11679983 GG genotype, rs3948464CC genotype in the case group are significantly higher than those in the control group. (2) Logistic regression analyzes rs1135791C/T, rs722555A/G, rs11679983A/G, rs3948464C/T, smoking history, family with TB, per capita living space and BMI were with relation to tuberculosis. (3) Sp110 gene rs722555A/G has the cross action with 3 points: rs1135791C/T, rs11679983A/G and rs3948464C/T, respectively. CONCLUSION: rs1135791C/T, rs722555 A/G, rs11679983A/G, rs3948464C/T may be the risk factors for susceptibility to tuberculosis in Chongqing Han People.
Subject(s)
Genetic Predisposition to Disease , Nuclear Proteins/genetics , Polymorphism, Single Nucleotide , Tuberculosis, Pulmonary/genetics , Case-Control Studies , China/ethnology , Female , Humans , Male , Minor Histocompatibility Antigens , Surveys and QuestionnairesABSTRACT
OBJECTIVE: To learn and analyze the psychological conditions and the influence factors of Sichuan immigrations so as to provide the science basis for the government. METHODS: Take residents generally questionnaire, symptom checklist (SCL90), psychosocial stress survey for groups(PSSG) and social support rating scale (SSRS) four questionnaires to collect and analyze the mental conditions and influences of Sichuan immigrations and local residents by cluster stratified random sampling. RESULTS: There is no difference in the sex, age, marriage, culture, occupation, economy and character between immigrations and local residents. Immigrations owned medical safeguard are less than local residents (P < 0.01). The SCL-90 (symptom checklist 90) and PSSG (psychosocial stress survey for groups) scores of Sichuan immigrations are higher than the local residents (P < 0.01). Social support of immigrations is worse than local residents (P < 0.01). 56.00% occupations are changed after the immigration. Multiple linear regression analysis that whether immigrates, the age, the marriage, the occupation, psychological stress and social support of migrants relate to the mental health of migrants. CONCLUSION: The mental health of Sichuan immigrations is bad, so the government should strengthen their financial support and pay attention to their humanist concern.
