Assembly of Heterocyclic C-Glycosides by Ru-Catalyzed C-H Activation/Cyclization with Carbonyl Sulfoxonium Ylide Glyco-Reagents.

New carbonyl sulfoxonium ylide glyco-reagents have been developed, enabling the synthesis of versatile heteroarene C-glycosides through a Ru-catalyzed C-H activation/annulation strategy. These reactions tolerate various saccharide donors and represent a significant advance in the stereoselective synthesis of heterocyclic C-glycosides. Furthermore, the strategy and methods could be applied to large-scale reactions and late-stage modifications of some structurally complex natural products or drugs.

Age Differences in Psychological Distress After Multiple Disaster Exposures: The Effect of Multidimensional Negative COVID-19 Impacts.

OBJECTIVE: This study examined how the multidimensional negative coronavirus disease (COVID-19) impacts contextualized the age differences in psychological distress following exposures to tornadoes and the COVID-19 pandemic. METHODS: Data were from a 2-wave panel study conducted at T1 (October 2020-August 2021) and T2 (May-August 2022). Latent class analysis was conducted to explore the patterns of negative COVID-19 impacts based on a sample of 1134 at T1. Negative binomial regressions were performed to examine the age differences in psychological distress at T2, based on the working sample (N = 554), as well as the moderating effect of identified class membership, with baseline psychological distress controlled. RESULTS: Three latent classes were identified: class 1 "low overall impacts," class 2 "moderate overall impacts with high emotional distress," and class 3 "severe overall impacts." Individuals ages 65 and over reported lower psychological distress at T2 relative to those ages 18-34 and 35-49. However, compared to people ages 18-34, 35-49, and 50-64, those ages 65 and over reported the greatest increases in T2 psychological distress if they had experienced moderate or severe overall COVID-19 impacts at T1. CONCLUSION: There is a pressing need for mental health interventions that are tailored to multi-disaster scenarios and age-related differences in long-term disaster recovery.

Potential factors associated with resilience among older adults in rural China: a multilevel analysis.

BACKGROUND: Resilience is crucial for older adults who experience adversities, but research on the issue in rural China remains limited. This study aims to examine factors associated with resilience among older adults in rural China, as related to different types of resilience, and under different levels of adversity. METHODS: Data were taken from the eight-wave (2001-2021) Longitudinal Study of Older Adults in Anhui Province, China. We used data from the eighth wave (2021) for the outcome variables and lagged predictors (2018) to avoid reverse causal effects. The study sample included individuals 60 years and above, excluding new participants from 2021, those without any adverse events, and any respondents with incomplete analytic data. Resilience was operationalized as residuals of the regressions of life satisfaction (Life Satisfaction Scale) and depressive symptoms (CES-D) on adversity, referred to as Type-1 and Type-2 resilience respectively. These two types of resilience were then treated as the outcome variables in subsequent multilevel regressions, with the predictors focusing on individual, social, and environmental characteristics and resources. This study adheres to STROBE guidelines. RESULTS: 43% of rural older adults exhibited both Type-1 and Type-2 resilience, whereas 18% exhibited only Type-1 resilience and 7% exhibited only Type-2 resilience. Common factors associated with both types of resilience included self-rated health, satisfaction with one's own financial situation, and the prestigiousness of social networks. Predictors for higher levels of Type-1 resilience included higher levels of financial and emotional support and more options for places of leisure. Predictors for higher levels of Type-2 resilience included greater access to medical care. The prestigiousness of social networks, higher levels of emotional support and instrumental support, access to medical care, and more options of places of leisure were positively associated with resilience in the low-adversity group (first tertile of adversity), only satisfaction with financial situation was positively correlated with the resilience of the middle-adversity group (second tertile), while better self-rated health, satisfaction with financial situation, and financial support yielded greater resilience in the high-adversity group (third tertile). CONCLUSIONS: We examined two types of resilience among older adults in rural China, and found that they have shared and unique associated factors. In addition, the potential factors influencing resilience varied with the level of adversity.

Disaster exposure and patterns of disaster preparedness: A multilevel social vulnerability and engagement perspective.

This study examined how community vulnerabilities contextualized the impact of exposure to five major disasters in 2017 on individuals' disaster preparedness. We pooled two panels of the Federal Emergency Management Agency (FEMA)'s National Household Survey in 2017 (pre-disaster) and 2018 (post-disaster) and further merged the data with 15 Centers for Disease Control and Prevention Social Vulnerability Index factors to examine the moderating impact of county-level vulnerabilities. Latent class analysis was used to identify patterns of disaster preparedness based on six preparedness items defined by FEMA with a total of 10,045 individuals. Three groups were identified and named basic preparedness (BP) group, high preparedness: socially engaged (HP-SE) group, and high preparedness: advanced socially engaged (HP-ASE) group. A working sample with a smaller sample size was constructed to include 2,179 individuals from 92 counties with disaster declarations of Hurricane Harvey, Hurricane Irma, Hurricane Maria, Hurricane Nate, and California Wildfires in 2017. Multinomial logistic regression indicated that post-disaster respondents were more likely to be in the HP-SE relative to the BP group. Two-level multinomial logistic regression showed that post-disaster respondents in communities with higher percentages of single-parent households and those of no vehicles were less likely to be in the HP-SE vs. the BP group. Post-disaster respondents in communities with higher percentages of unemployment, no high school diploma, and occupied housing units with more people than rooms were less likely to be in the HP-ASE vs. the BP group. Post-disaster respondents in communities with higher percentages of older adults and mobile homes were more likely to be in the HP-SE vs. the BP group. The findings also highlighted the importance of social engagement in disaster preparedness disparities and the need for community-level intervention to promote individuals' disaster preparedness.

Children's Divorce and their Financial Support to Older Parents in Rural China.

This study examined how adult children's divorce affected their financial support to older parents in rural China and how that relationship was dependent on children's gender. The sample was from rural Anhui Province and the working sample included 1629 older parents who reported their interactions with 6210 children across six waves of observations in 14 years (2001-2015). Generalized Estimating Equations showed that divorced sons provided less financial support to their parents than married sons. In contrast, divorced daughters did not necessarily provide less financial support than married daughters. This gender difference was statistically significant. The findings were discussed in the context of changing rural Chinese families, where the norm of filial piety is still strong but patrilineal tradition and gender ideology have experienced desynchronized changes.

The Proximity of Disaster Experiences and Financial Preparedness for Emergencies in the US.

OBJECTIVE: This study investigated how the proximity of disaster experience was associated with financial preparedness for emergencies. METHODS: The data used were from the 2018 National Household Survey, which was administered by the Federal Emergency Management Agency. The working sample included 4779 respondents. RESULTS: Logistic Regression showed that the likelihood of setting aside emergency funds tended to be the highest between 2-5 years after experiencing a disaster, which declined slightly but persisted even after 16 years. Recent disaster experience within 1 year did not show a significant impact, indicating a period of substantial needs. However, the proximity of disaster experience did not significantly affect the amount of money set aside. CONCLUSION: It is suspected that increased risk perception related to previous experiences of disasters is more relevant to the likelihood of preparing financially; whereas other capacity-related factors such as income and having a disability have more effect on the amount of money set aside.

How does leaders' information-sharing behavior affect subordinates' taking charge behavior in public sector? A moderated mediation effect.

Introduction: Taking charge behavior (TCB) of civil servants is an important part of individual innovation performance, which is not only a key step for innovation in the public but also a real need for high-quality cadres construction in the public sector in the new era. Therefore, it is necessary to carry out an in-depth discussion on civil servants' taking charge behavior. Based on the theory of planned behavior, this paper constructs the framework of"cognition-motivation-behavior" to deeply explore the relationship between public sector leaders' information-sharing behavior and subordinates' taking charge behavior, as well as the mediating and moderating effects of subordinates' public service motivation and emotional trust. Method: This study collected 200 civil servants' questionnaires by online survey, and conducted regression analysis through SPSS/AMOS/PROCESS. Result and discussion: The empirical study finds that the information-sharing behavior of leaders in the public sector can significantly affect the TCB of subordinates; the public service motivation partially mediates the relationship between them; emotional trust positively moderates the mediation effect of public service motivation in the relationship between leaders' information-sharing behavior and subordinates' TCB in the public. This study not only enriches the research on civil servants' TCB theoretically but also provides meaningful enlightenment for promoting civil servants' taking charge behavior.

Financial Preparedness for Emergencies: Age Patterns and Multilevel Vulnerabilities.

Guided mainly by the social vulnerability perspective and life course perspective, this study examined age patterns of financial preparedness for emergencies and how they were contextualized by vulnerabilities at the individual and community levels. We matched data from the Federal Emergency Management Agency 2018 National Household Survey and 15 indicators of the Social Vulnerability Index at the county level. Two-level logistic regressions were conducted with the working sample, which included 4,623 respondents from 958 counties. The results showed that adults aged 18 to 44 were more likely than those aged 65 to 74 to set aside money for emergencies among Hispanics, those with minor children in the household, and in communities with higher levels of poverty, higher percentages of minorities, and higher percentages of no vehicles, but less likely to do so among the White and those with insurance. The findings were discussed within a multilevel layered vulnerability framework.

Which Household Emergency Plans are More Helpful in Tornadoes? Through the Lens of Gerontology.

OBJECTIVE: This study investigated how the effectiveness of household emergency plans during tornadoes was associated with family discussions, and the attributes of the plan for different age groups. METHODS: A telephone survey was conducted in 2014, one year after two 2013 Enhanced Fujita 4/5 tornadoes. The working sample included 223 respondents who reported having a household emergency plan before the tornadoes. The latent class analysis was used to identify the patterns of the plans and develop a typology based on their content. Logistic regression was used to examine predictors for plan effectiveness. RESULTS: Two classes of plans were identified: quality plans that were rich in content and limited plans that had lower levels of content richness. Older adults were less likely to have quality plans and less likely to have family discussions. Quality of the plan and discussions with family members increased plan effectiveness among older adults, but not younger adults. CONCLUSIONS: Better emergency planning could be more important for older than for younger adults. The findings were discussed from a gerontological perspective that focuses on older adults' unique needs, vulnerabilities, and resilience factors.

Factors Associated with Death Anxiety Among Rural Chinese Older Adults: The Terror Management Perspective.

OBJECTIVES: The aim of this study was to examine how the factors suggested by the Terror Management Theory are associated with death anxiety among rural Chinese older adults. METHOD: Data were derived from a longitudinal survey of older adults aged 60 and above, had at least one living child, and were living in rural areas of Anhui Province. The working sample included 1,362 older adults. Two-level random effects models were used. RESULTS: Children's financial support was negatively related to death anxiety, whereas emotional closeness with children was positively related to death anxiety. Older women reported more death anxiety than older men. Functional limitations were positively associated with death anxiety, and the widowed reported less death anxiety than the married. We did not find a significant association between religious belief and death anxiety. DISCUSSION: The study highlights the importance of culture in shaping death anxiety among older adults in rural China.

Chinese American Caregivers' Attitudes Toward Tube Feeding for Persons with Dementia - USA, 2021-2022.

What is already known about this topic?: Little is known about Chinese American dementia caregivers' attitudes toward tube feeding. What is added by this report?: To address this knowledge gap, the paper seeks to characterize participants' attitudes toward tube feeding based on a survey conducted among Chinese American dementia caregivers. What are the implications for public health practice?: It is crucial to develop culturally tailored interventions to promote knowledge on tube feeding and advance care planning engagement in Chinese American communities.

[Characteristics of Atmospheric Particulate Matter Pollution and the Unique Wind and Underlying Surface Impact in the Twain-Hu Basin in Winter].

To understand the recent characteristics of atmospheric environmental changes in the Twain-Hu(Hunan-Hubei) Basin, including the middle reaches of the Yangtze River, this paper uses near-surface PM2.5 and PM10 observational data for the Twain-Hu Basin in the winters of 2015 to 2019, combined with wind-speed, topography, the normalized difference vegetation index(NDVI), and other datasets. The results show that:① PM2.5 pollution occurred frequently in the winters of 2015-2019 in the Twain-Hu Basin, and Xiangyang and Jingmen in the western part of the basin, experience PM2.5 pollution on an average of 62 and 61 days in winter(PM2.5>75 µg·m-3). And the heavy pollution days in Xiangyang reached 19 more days(PM2.5>150 µg·m-3), indicating that the Twain-Hu Basin is an air pollution center in the middle reaches of the Yangtze River Basin; ② Spatially, pollution in the Twain-Hu Basin is heavier in the northwest than in the southeast, and in the urban agglomeration, which is mainly related to the regional transport of air pollutants by the winter monsoon and the high levels of emissions from urban areas; ③ A "U-shaped" nonlinear relationship was observed between near-surface wind speeds and PM2.5 and PM10 concentrations. The inflection points of PM2.5 and PM10 concentrations were 153 and 210 µg·m-3, respectively. This implies that the accumulation of local atmospheric particulate matter in the Twain-Hu Basin dominates light/medium pollution, while the regional transport of air pollutants dominates period of severe pollution; and ④ PM2.5 and PM10 in winter were significantly negatively correlated with terrain height and the NDVI, which reflects the atmospheric environmental effects of topography and urbanization.

Improving Care for Older Adults in China: Development of Long-Term Care Policy and System.

This special issue covers several important topics related to long-term care (LTC) systems and policy development in China. It provides a good contextual background on the development of the LTC system in China as well as the needs and preferences of LTC from family and older adults' perspectives. In addition, this issue covers the topic of evaluation of a recently developed long-term care nursing insurance and provides an example of family caregiving for persons with dementia within the Chinese context. The authors in this special issue also provided insights into the impact of the COVID-19 pandemic on older adults' life and LTC quality, and explored potential strategies to handle the challenges during and post-pandemic.

Effectiveness of Household Emergency Plans in Violent Tornadoes.

OBJECTIVE: This study examined factors that were associated with the effectiveness of pre-existing household emergency plans during the 2011 EF5 Joplin and EF4 Tuscaloosa tornadoes. We focused on whether discussing with family members helped increase the plan's effectiveness. METHODS: A telephone survey based on random sampling was conducted in 2012 with 1006 respondents in both cities. Each city experienced huge losses, injuries, and casualties. The working sample included 494 respondents who had a household emergency plan in place before these tornadoes. RESULTS: Multinomial logistic regression showed that discussing with family members increased the helpfulness of the plan in Joplin, where people had not experienced tornadoes frequently and were less prepared for tornadoes relative to residents in Tuscaloosa. CONCLUSIONS: This study provides empirical evidence on the importance of encouraging family involvement when making household emergency plans, especially in places that are less prepared for disasters than those that are better prepared.

The Money Smart for Older Adults Program: A Qualitative Study of the Participants' Financial Well-Being.

The Money Smart for Older Adults is a program that is tailored to older adults to raise awareness for the risk of financial exploitation and teach them how to plan and make informed financial decisions. The purpose of this study was to examine financial circumstances of older adults in the program and to explore how the program could better support their financial well-being. Individual, in-depth interviews were conducted with 29 older adults who attended the program provided by a local agency in northern Texas. Three themes emerged when exploring financial circumstances of the participants: (1) victims of financial fraud scams, (2) struggles with money management, and (3) inability to make ends meet. The program has been serving older adults, particularly ethnically diverse older adults and low-income older adults who may not have access to financial education workshops or seminars provided by private financial institutions. The Money Smart for Older Adults Program was perceived as helpful among the participants because it raised awareness of the importance of their financial well-being and it also supported their financial decision making.

Education, adult children's education, and depressive symptoms among older adults in rural China.

This study examines whether children's education amplifies the effect of older adults' own education on their later life depressions in rural China. Data derives from six waves of panel data (2001, 2003 2006, 2009, 2012 and 2015) from the Longitudinal Study of Older Adults in Anhui Province, China. Random effect models showed that both older adults' own education and adult children's education had direct effects on depressive symptoms of older adults. Older adults' education influenced children's education, and in turn influenced intergenerational support from children, which consequently influenced depressive symptoms of older adults. Taken together, children's education amplifies the effect of older adults' own education on their depressive symptoms in rural China. This process increases health inequalities among older adults as a result of associated educational achievements in two generations. Educational policy should promote the equality of educational attainment of individuals in the future.

The Impact of Living Alone and Intergenerational Support on Depressive Symptoms Among Older Mexican Americans: Does Gender Matter?

The study examined gender differences in the impact of living alone and intergenerational support on depressive symptoms among Mexican American older adults. The sample included 335 parent-adult child pairs which are nested within 92 Mexican American respondents, because each respondent reported their specific relationships with each child. Clustered regression analysis showed gender differences in the impact of living alone and intergenerational support on depressive symptoms among Mexican American older adults. In general, older men provided and received less intergenerational support than older women, but their depressive symptoms were more susceptible to living alone and different types of intergenerational support. Factors such as living alone, receiving instrumental support were associated with more depressive symptoms in older men than inolder women, whereas older men benefited more from the emotional closeness with children than older women. The findings highlight the need for a gender-specific approach to future research on this topic.

Pulmonary Textures Classification via a Multi-Scale Attention Network.

Precise classification of pulmonary textures is crucial to develop a computer aided diagnosis (CAD) system of diffuse lung diseases (DLDs). Although deep learning techniques have been applied to this task, the classification performance is not satisfied for clinical requirements, since commonly-used deep networks built by stacking convolutional blocks are not able to learn discriminative feature representation to distinguish complex pulmonary textures. For addressing this problem, we design a multi-scale attention network (MSAN) architecture comprised by several stacked residual attention modules followed by a multi-scale fusion module. Our deep network can not only exploit powerful information on different scales but also automatically select optimal features for more discriminative feature representation. Besides, we develop visualization techniques to make the proposed deep model transparent for humans. The proposed method is evaluated by using a large dataset. Experimental results show that our method has achieved the average classification accuracy of 94.78% and the average f-value of 0.9475 in the classification of 7 categories of pulmonary textures. Besides, visualization results intuitively explain the working behavior of the deep network. The proposed method has achieved the state-of-the-art performance to classify pulmonary textures on high resolution CT images.

Risk and Resiliency in the Relationship Between Widowhood and Depressive Symptoms Among Older Mexican Americans.

This study examined the association between widowhood and depressive symptoms and the extent to which the association is contingent upon risk and resiliency, including immigration status, functional limitations, financial strains, and intergenerational support, among older Mexican Americans. The sample included 344 parent-child pairs reported by 83 respondents. Clustered regression analysis showed that widowhood elevated risks for depressive symptoms. We found that having some functional limitations, having more children and living in the same city with children exacerbated the adverse effects of widowhood on depressive symptoms. We also found that living in the same city with children increased the detrimental effects of widowhood on the depressive symptoms in men, whereas we did not find this pattern in women. The findings highlight the heterogeneity within the widowed Mexican American older adults. Implications for future research and practice are discussed.

Preparation of a biomimetic ECM surface on cardiovascular biomaterials via a novel layer-by-layer decellularization for better biocompatibility.

Endothelial extracellular matrix (EC-ECM) modification by decellularization is generally recognized as an effective method for cardiovascular biomaterials to enhance their biocompatibility. However, the now available EC-ECM was mainly secreted by the in vitro cultured endothelial cells which lacked a physiological growth environment in vivo, such as blood flow shear stress (BFSS) acting, thus had a serious defect of biocompatibility. Our previous work markedly improved the biocompatibility of the EC-ECM modified materials by simulating the BFSS acting to control the endothelial cells with hyaluronic acid (HA) micro-pattern. In this contribution, the EC-ECM was further enriched onto the HA micro-pattern via a novel layer-by-layer decellularizatio method. In vitro platelets adhesion/activation, macrophages attachment test and ex vivo blood experiment of New Zealand White Rabbits suggested better blood compatibility and anti-inflammation property of this novel biomimetic ECM surface. The endothelial cells culture tests and in vivo rat subcutaneous implantation also proved its good pro-endothelialization function and tissue compatibility. In summary, the present study demonstrated better biocompatibility of the novel biomimetic ECM surface and its potential application for cardiovascular biomaterials modification.