[Influence of different types of experimental obesity on resistance of the mouse to infection by Salmonella typhimurium and Klebsiella pneumoniae]. / Influence de divers types d'obésité expérimentale sur la résistance de la souris à l'infection par Salmonella typhimurium et Klebsiella pneumoniae.

Resistance to infections inducing two types of immune response, humoral and cell-mediated, has been measured in mice after Salmonella typhimurium and Klebsiella pneumoniae inoculation; the animals exhibited different kinds of obesity: genetic, ob/ob and db/db mutants, induced by fat diet or gold thioglucose (aurothioglucose) injection (determining obesity of central origin). Klebsiella infection was aggravated in all types of obesity. Salmonella infection was aggravated in genetically diabetic and dietary-obese mice. The two kinds of genetically obese mice show an important functional decrease in splenic lymphocytes. In contrast, aurothioglucose-obese mice were more resistant than controls.

[Effect of experimental alcoholic intoxication on the cell-mediated immune response in mice]. / Effet de l'intoxication expérimentale par l'alcool sur la réponse d'immunite à médiation cellulaire de la souris.

Repeated ip injection of ethyl alcohol in a relatively high dose depressed the immune response, to a greater degree in Swiss mice than in C57BL/6 mice, as shown by a diminution in granuloma size and in the hypersensitivity reaction to tuberculin compared with untreated controls. The control of bacillary multiplication in the popliteal lymph node was more efficient in alcohol-treated Swiss mice than in the corresponding controls, but was less efficient in alcohol-treated C57BL/6 animals than in their controls. Alcohol treatment caused no reduction in the number of circulating lymphocytes, and no modification of the distribution of B and T lymphocytes in the spleen, or of the stimulation of T lymphocytes in the presence of mitogens.

[Effect of moderate protein-calorie deprivation on cell-mediated immunity in mice]. / Effet d'une carence protéino-calorique modérée sur l'immunité à médiation cellulaire de la souris.

Mild protein-calorie deprivation in mice decreases their early nonspecific inflammatory response to an injection of BCG or tuberculin into the footpad. After an injection of BCG, the size of the granuloma and the delayed hypersensitivity reaction to tuberculin significantly decreased. This decrease in cell-mediated immunity was paradoxically accompanied by a fall in bacillus multiplication at the popliteal ganglion, i.e. the site of BCG injection. A reduction in microbial multiplication was also observed in the spleen after intraperitoneal injection of Listeria and in the liver after intravenous injection.

[Comparative effects of a diet enriched in live or heated yogurt on the immune system of the mouse]. / Effets comparé d'un régime enrichi en yoghourt vivant ou thermisé sur le système immunitaire de la souris.

Growth was fastest in mice fed yogurt. There was no difference in the effects of live or heated yogurt on the ponderal curve or the organ weight of vaccinated or unvaccinated mice. Sera antitoxin levels were slightly elevated in animals fed live yogurt and given an antitetanus vaccination at the particular concentrations used. Significantly high IgG2a immunoglobulin levels were found only in unvaccinated mice fed live yogurt. Histological examination before, and particularly after, antitetanus vaccination confirmed these findings in the thymus and especially in the spleen.