ABSTRACT
Smoking and occupational exposure to noise are factors with independent predisposition to sensorineural hearing loss. This is a sinergistic and additive effect. Nevertheless, we have observed that withdrawal of smoking stops the progression on hearing loss in occupational groups with an acoustic exposition lesser than 80 dB SPL. Actually, there is not an unique ethiologic hypothesis.
Subject(s)
Hearing Loss, Noise-Induced/diagnosis , Nicotine/adverse effects , Occupational Diseases/diagnosis , Smoking/adverse effects , Substance Withdrawal Syndrome/etiology , Adult , Audiometry, Pure-Tone , Hearing Loss, Noise-Induced/epidemiology , Hearing Loss, Sensorineural/diagnosis , Hearing Loss, Sensorineural/epidemiology , Humans , Male , Occupational Diseases/epidemiology , Severity of Illness Index , Smoking/epidemiology , Substance Withdrawal Syndrome/epidemiologyABSTRACT
El consumo de tabaco y la exposición laboral a ruido son factores que independientemente predisponen a la hipoacusia neurosensorial. Este efecto es sinérgico y aditivo. Sin embargo, hemos observado que la supresión del tabaquismo condiciona la anulación en la progresión de la hipoacusia en grupos laborales en los que la exposición acústica no supera los 80 dB SPL, sin que en la actualidad pueda proponerse una única hipótesis causal
Smoking and occupational exposure to noise are factors with independent predisposition to sensorineural hearing loss. This is a sinergistic and additive effect. Nevertheless, we have observed that withdrawal of smoking stops the progression on hearing loss in occupational groups with an acoustic exposition lesser than 80 dB SPL. Actually, there is not an unique ethiologic hypothesis
Subject(s)
Male , Adult , Humans , Hearing Loss, Noise-Induced/diagnosis , Nicotine/adverse effects , Tobacco Use Disorder/adverse effects , Substance Withdrawal Syndrome/etiology , Occupational Diseases/diagnosis , Audiometry, Pure-Tone , Hearing Loss, Noise-Induced/epidemiology , Hearing Loss, Sensorineural/diagnosis , Hearing Loss, Sensorineural/epidemiology , Tobacco Use Disorder/epidemiology , Substance Withdrawal Syndrome/epidemiology , Severity of Illness Index , Occupational Diseases/epidemiologyABSTRACT
INTRODUCTION: To evaluate the therapeutic response and the rheologic and immunological characteristics in subjects bearing of rapidly progressive sensorineural hearing loss (RPSHL). PATIENTS AND METHODS: A comparative prospective study on three groups of damaged ears treated with piracetam (n=29), corticosteroids (n=32) and plabcebo (n=25). Hearing loss and recovery level, whole blood filterability (WBF) and a Western-blot (WB) to anticochlear antibodies were evaluated. RESULTS: Recovery average was 20,8 +/- 55,9% in the first group, with progressive of deafness in the rest (p<0,01). WB did not show differences among groups. The higher WBF at the end of therapy was detected on group 1 (20,36 +/- 2,54 Vs 18,42 +/- 3,42 microl/seg on group 3; p<0,05). Moreover, it impaired only on those treated with piracetam, with statistically significative differences over the other two groups. CONCLUSIONS: We detected alterations on WBF in patients with RPSHL that justify the use of rheoactive measures as a pathophysiological therapy.
Subject(s)
Adrenal Cortex Hormones/therapeutic use , Hearing Loss, Sensorineural/drug therapy , Piracetam/therapeutic use , Adult , Blood Viscosity , Disease Progression , Double-Blind Method , Female , Hearing Loss, Sensorineural/blood , Hearing Loss, Sensorineural/etiology , Hearing Loss, Sensorineural/immunology , Humans , Male , Middle Aged , Prospective Studies , Time FactorsABSTRACT
Introducción: Valorar respuesta terapéutica y características reológicas e inmunológicas en sujetos con hipoacusia neurosensorial rápidamente progresiva (HNSRP). Pacientes y métodos: Estudio comparativo prospectivo sobre tres grupos de oídos dañados y tratados con piracetam (n=29), corticoides (n=32) y placebo (n=25). Se evaluó pérdida y recuperación auditiva, filtrabilidad en sangre total (FST) y un test de Western-blot (WB) para anticuerpos anticocleares. Resultados: El porcentaje de recuperación fue del 20,8±55,9% en el primer grupo, existiendo progresión de la hipoacusia en los otros dos (p<0,01). El WB no evidenció diferencias entre grupos. La mayor FST al final del tratamiento fue en el grupo 1 (20,36±2,54 Vs 18,42±3,42 μl/seg en grupo 3; p<0,05) y sólo mostró recuperación en tratados con piracetam, con diferencias estadísticamente significativas sobre los otros dos grupos. Conclusiones: En pacientes con HNSRP se detectan alteraciones en la FST que justifican el empleo de medidas reoactivas como tratamiento fisiopatológico
Introduction: To evaluate the therapeutic response and the rheologic and immunological characteristics in subjects bearing of rapidly progressive sensorineural hearing loss (RPSHL). Patients and methods: A comparative prospective study on three groups of damaged ears treated with piracetam (n=29), corticosteroids (n=32) and plabcebo (n=25). Hearing loss and recovery level, whole blood filterability (WBF) and a Western-blot (WB) to anticochlear antibodies were evaluated. Results: Recovery average was 20,8±55,9% in the first group, with progressive of deafness in the rest (p<0,01). WB did not show differences among groups. The higher WBF at the end of therapy was detected on group 1 (20,36±2,54 Vs 18,42±3,42 μl/seg on group 3; p<0,05). Moreover, it impaired only on those treated with piracetam, with statistically significative differences over the other two groups. Conclusions: We detected alterations on WBF in patients with RPSHL that justify the use of rheoactive measures as a pathophysiological therapy
