ABSTRACT
Paediatric cataracts can present a diagnostic dilemma to ophthalmologists. Next-generation DNA sequencing (NGS) has been promoted as a tool to expedite the diagnosis of an underlying cause in such cases.1 The authors present an unusual case of bilateral cataracts in an 11-year-old girl as the first presenting feature of new type 1 diabetes mellitus. Prompt diagnosis and subsequent management of this potentially life-threatening condition were achieved through careful history taking and targeted biochemical testing. The authors feel this case highlights the significance of simple measures such as thorough history taking in the assessment of paediatric cataracts. It is important that these skills are not lost through the availability of clinical tools such as NGS.
Subject(s)
Cataract/etiology , Diabetes Mellitus, Type 1/complications , Cataract/therapy , Cataract Extraction , Child , Diabetes Mellitus, Type 1/blood , Diabetes Mellitus, Type 1/diagnosis , Female , Humans , Medical History TakingABSTRACT
Intracoronary streptokinase administration has been an effective procedure for establishing reperfusion of an evolving myocardial infarction by lysing the thrombus that is usually responsible for the infarction. After reperfusion is accomplished, appropriate management of the patient must be planned to provide the best chance for assuring continued vessel patency, and appropriate management of the patient's residual coronary artery disease also must be considered. In selected patients, percutaneous transluminal coronary angioplasty of the residual coronary lesion has been performed successfully immediately following reperfusion with streptokinase. Early coronary artery bypass graft surgery has been performed with good results in other patients. The appropriate management of the patient with acute myocardial infarction is still evolving, and only with additional study and experience will the "best" approach in the management of these patients be defined.
Subject(s)
Myocardial Infarction/therapy , Streptokinase/therapeutic use , Adult , Aged , Calcium Channel Blockers/administration & dosage , Calcium Channel Blockers/therapeutic use , Drug Therapy, Combination , Female , Heart , Heparin/administration & dosage , Heparin/therapeutic use , Humans , Injections/methods , Injections, Intravenous , Male , Middle Aged , Myocardial Infarction/drug therapy , Nitroglycerin/administration & dosage , Nitroglycerin/therapeutic use , Recurrence , Streptokinase/administration & dosage , Time FactorsABSTRACT
The intracellular distribution of 45Ca in the rat heart was studied following separate and combined administration of quinidine and propranolol. Both drugs caused an increased uptake of 45Ca in the nuclear-cell membrane fraction but quinidine suppressed the uptake in mitochondrial and microsomal fractions whereas propranolol did not affect the uptake of 45Ca in these fractions. In addition, there was an increase in serum radioactivity noted with quinidine which was not observed with propranolol. Combined treatment resulted in restoration of normal values for blood and mitochondrial fractions and an increased uptake of 45Ca in the microsomal fraction.
