ABSTRACT
Tongue cancer is more prevalent in male smokers and alcoholics. Although an increased incidence of tongue cancer has been noted in non-smoking and non-alcoholic women, reports of its occurrence in mother and daughter are extremely rare. Here, we report a case of a non-smoking and non-alcoholic mother and her daughter diagnosed and treated surgically for tongue squamous cell carcinoma (SCC). The daughter is still being monitored and the mother died from complications from COVID-19 after 6 years of treatment. This report shows that OSCC should be considered in the differential diagnosis of oral ulcerated lesions in non-smoking and non-alcoholic women, especially if there is a family history of first-degree oral cancer.
Subject(s)
Tongue Neoplasms , Female , Humans , Middle Aged , Carcinoma, Squamous Cell/pathology , Carcinoma, Squamous Cell/genetics , COVID-19/complications , Mothers , Non-Smokers/statistics & numerical data , Tongue Neoplasms/pathology , AgedABSTRACT
Warthin's tumor (WT) is a benign and frequent salivary gland tumor primarily affecting the parotid gland. In some cases, this tumor can involve the extra parotid region and affect cervical lymph nodes. Fine-needle aspiration can be the first step in the diagnostic approach to lymphadenopathy; however, specimens from intra-nodal WT can present a potential pitfall, leading to a misdiagnosis of metastasis. Here, we report an unusual case of a patient with bilateral WT in parotid lymph nodes misdiagnosed as metastases. In addition, we highlight the cytopathological aspects of WT to alert cytopathologists about this challenging diagnosis.
Subject(s)
Adenolymphoma , Carcinoma , Parotid Neoplasms , Humans , Parotid Neoplasms/diagnosis , Parotid Neoplasms/pathology , Adenolymphoma/diagnosis , Adenolymphoma/pathology , Carcinoma/pathology , Parotid Gland/pathology , Lymph Nodes/pathologyABSTRACT
Tobacco and alcohol consumption are the main risk factors for head and neck cancer (HNC). However, some individuals do not have a history of addiction and even so they develop the disease. This study evaluated clinicopathological and prognostic features of non-smoking and non-drinking (NSND) HNC patients. A sample of smoking and/or drinking (SD) HNC patients was used to explore the differences with NSND patients. Data were obtained from 667 patients with squamous cell carcinoma in oral cavity, oropharynx or larynx. The group of NSND individuals represented 12.6% of the HNC patients and had higher prevalence of women and elderly compared to SD group. Among NSND patients, most of them displayed tumors in oral cavity, advanced clinical staging and absence of second primary tumor. NSND HNC patients had higher tumor recurrence and increased overall and specific survival rates at 5-years follow-up. The NSND group showed higher prevalence of tumors in lips and alveolar ridge, lower rate of tumors in floor of mouth and no tumor in soft palate. NSND patients show a distinct profile from that found in SD patients. Clinicopathological features from NSND patients should be considered for HNC management.
Subject(s)
Head and Neck Neoplasms , Mouth Neoplasms , Aged , Alcohol Drinking/adverse effects , Alcohol Drinking/epidemiology , Female , Head and Neck Neoplasms/epidemiology , Humans , Mouth Neoplasms/epidemiology , Mouth Neoplasms/pathology , Neoplasm Recurrence, Local , Prognosis , Risk FactorsABSTRACT
Oral melanoma is an extremely aggressive and rare tumor. Commonly, oral melanomas are diagnosed as invasive tumors, which considerably reduces the chances of cure. In situ oral melanomas being exceedingly rare, which makes its clinicopathological and prognostic characteristics poorly known. Herein, we report a case of 67-year-old non-white woman with a large black patch on the maxillary alveolar mucosa. A biopsy was made and microscopical analysis revealed moderate atypical junctional melanocytic. Tumor cells were positive for S100 (Polyclonal), Melan-A (Clone A103) and Melanosome (HMB-45). The diagnosis of in situ oral melanoma was made and the patient was treated surgically with partial maxillectomy and rehabilitated with obturator prosthesis. Although extremely rare in situ melanomas should be considered in the differential diagnosis of non-invasive pigmented lesions of the oral mucosa.
Subject(s)
Melanoma/diagnosis , Melanoma/therapy , Mouth Mucosa/pathology , Aged , Female , Humans , Melanoma/pathologyABSTRACT
BACKGROUND: To describe the clinicopathologic profile of young patients with head and neck squamous cell carcinoma (HNSCC) and compare to middle-aged and elderly adults. MATERIAL AND METHODS: Patients' individual records were reviewed for clinicopathologic data. Eighty-nine patients with age 18-45 years old met the inclusion criteria of the study. Two additional groups of middle-aged (n = 89) and old (n = 89) adults were set to comparative analysis. RESULTS: Young patients represented 11.9% of all patients diagnosed with HNSCC. Women were more affected by HNSCC in the young and elder groups (p= 0.04), and young patients were more prone to be non-smokers (p= 0.01) and have lymph node metastasis at the time of diagnosis (p = 0.04). In the young group, patients diagnosed with the disease in advanced stages were more prone to have a positive familial history of cancer (p= 0.04), a positive status of alcohol consumption (p= 0.03), and to be heavy drinkers (p= 0.01). Survival was not different for the young group in comparison to the other groups. CONCLUSIONS: HNSCC in young patients had a different profile when compared to older patients, especially regarding sex and exposure to the classic risk factors for this disease. The survival of the young group is similar to the older groups and advanced clinical stage is predictor of worse survival
No disponible
Subject(s)
Humans , Male , Female , Adolescent , Young Adult , Adult , Middle Aged , Aged , Aged, 80 and over , Carcinoma, Squamous Cell/epidemiology , Head and Neck Neoplasms/epidemiology , Carcinoma, Squamous Cell/pathology , Head and Neck Neoplasms/pathology , Age and Sex Distribution , Neoplasm Staging , Time Factors , Risk Factors , Kaplan-Meier Estimate , Retrospective Studies , Brazil/epidemiologyABSTRACT
Heterotopic ossification has been described in papillary thyroid carcinoma in association with high incidence of extrathyroidal invasion, multifocality, lymph node metastasis, and older age. Nevertheless, it has not been described as a specific subtype of papillary thyroid carcinoma, because of its rarity. We described the case of an 80-year-old female patient, with familial history of papillary thyroid carcinoma. In the annual screening examination, she was diagnosed with thyroid nodules. The patient was submitted to a thyroidectomy because the fine needle aspiration cytology was positive for malignancy according to the Bethesda classification. The surgical specimen analyses showed a multifocal papillary carcinoma with one major lesion in the left lobe measuring 0.9 cm, and two small lesions (0.4 cm and 0.2 cm) in the right lobe. Only the biggest lesion in the right lobe had the osteoid matrix with rare osteoclasts and fat metaplasia with progenitor cells. There was perineural invasion, but vascular invasion was not identified. The margins were free and there was no extrathyroidal extension. In the left lobe there was an oncocytic nodule and a lipomatous follicular nodule. In recent years there has been a significant increase in the diagnosis of thyroid cancer, mainly because of the finding of microcarcinomas as a result of many requests for cervical image exams. Future studies may define (i) whether papillary thyroid carcinoma with heterotopic ossification is a true histological variant; (ii) the causes of that alteration; and (iii) eventual follow-up implications.
ABSTRACT
Heterotopic ossification has been described in papillary thyroid carcinoma in association with high incidence of extrathyroidal invasion, multifocality, lymph node metastasis, and older age. Nevertheless, it has not been described as a specific subtype of papillary thyroid carcinoma, because of its rarity. We described the case of an 80-year-old female patient, with familial history of papillary thyroid carcinoma. In the annual screening examination, she was diagnosed with thyroid nodules. The patient was submitted to a thyroidectomy because the fine needle aspiration cytology was positive for malignancy according to the Bethesda classification. The surgical specimen analyses showed a multifocal papillary carcinoma with one major lesion in the left lobe measuring 0.9 cm, and two small lesions (0.4 cm and 0.2 cm) in the right lobe. Only the biggest lesion in the right lobe had the osteoid matrix with rare osteoclasts and fat metaplasia with progenitor cells. There was perineural invasion, but vascular invasion was not identified. The margins were free and there was no extrathyroidal extension. In the left lobe there was an oncocytic nodule and a lipomatous follicular nodule. In recent years there has been a significant increase in the diagnosis of thyroid cancer, mainly because of the finding of microcarcinomas as a result of many requests for cervical image exams. Future studies may define (i) whether papillary thyroid carcinoma with heterotopic ossification is a true histological variant; (ii) the causes of that alteration; and (iii) eventual follow-up implications.
Subject(s)
Humans , Female , Aged, 80 and over , Thyroid Neoplasms/complications , Ossification, Heterotopic/pathology , Carcinoma, Papillary/complications , Thyroid Nodule/complicationsABSTRACT
BACKGROUND: This article reports a rare case of metastasis of salivary duct carcinoma of the parotid gland to the gingiva and reviews the occurrence of metastatic processes to the oral mucosa. METHODS: A 67-year-old white male presented with a chief complaint of a painless nodular tissue growth on the gingiva with reportedly 5 months of evolution. The intraoral examination revealed a reddish, superficially ulcerated nodular lesion ( approximately 2 cm in diameter) on the right mandibular buccal attached gingiva, and the clinical aspect was that of a benign reactive lesion. The patient had undergone a parotidectomy for removal of a salivary duct carcinoma of the parotid gland almost 1 year before. A biopsy of the gingival lesion was performed, and the biopsied tissue was forwarded for histopathologic examination. RESULTS: The analysis of the histopathologic sections of the gingival lesion revealed histomorphologic characteristics very similar to those of the primary parotid gland tumor. The definitive diagnosis was gingival metastasis from a salivary duct carcinoma of the parotid gland. The patient died of complications of a pulmonary metastasis 1 month after the diagnosis of the oral metastatic lesion. CONCLUSIONS: Gingival lesions that mimic reactive and hyperplastic lesions may be metastases from malignant neoplasias of diverse origins. An accurate and timely diagnosis is crucial to establish proper and immediate treatment of the metastatic tumor and possibly identify an occult primary malignant neoplasia.
Subject(s)
Carcinoma, Ductal/secondary , Gingival Neoplasms/secondary , Parotid Neoplasms/pathology , Salivary Ducts/pathology , Aged , Carcinoma, Ductal/pathology , Fatal Outcome , Humans , Lung Neoplasms/secondary , MaleABSTRACT
Um estudo foi realizado no Centro de Oncologia Bucal da Universidade Estadual Paulista, Campus de Araçatuba. Entre 88 casos de câncer atendidos no Centro de tratamento oncológico entre 1991 e 2003, 80 casos de câncer de laringe foram identificados em homens. Sexo, idade, uso de tabaco e ßlcool, realização de cirurgia e tratamentos oferecidos após a cirurgia foram dados obtidos de pacientes com um questionßrio padrão. O maior número de casos de câncer de laringe ocorreu em região glótica e necessitou de intervenção cirúrgica (laringectomia parcial ou total). A freqüência de câncer de laringe foi mais alta em fumantes e foi mais comum em idade entre 50 e 69 anos. O tratamento fonoaudiológico e a utilização de prótese estética ainda estão restritos a menor porcentagem dos pacientes.
Subject(s)
Humans , Male , Female , Alcoholic Beverages/adverse effects , Laryngectomy , Laryngeal Neoplasms/surgery , Laryngeal Neoplasms/therapy , Tobacco Use Disorder/adverse effects , Cohort Studies , Age Factors , Sex Factors , Surveys and QuestionnairesABSTRACT
Os autores descrevem uma técnica de confecção de prótese nasal, em que o modelo do nariz do paciente, antes da perda, serviu como base para a escultura e modelagem desse órgão. O método proposto facilita sessões clínicas e viabiliza uma reprodução mais próxima à fisionomia do paciente.
Subject(s)
Maxillofacial Prosthesis , Nose/surgery , Prostheses and ImplantsABSTRACT
Os autores descrevem um caso de coristoma osteocartilaginoso localizado no dorso da língua. Foi revisada a literatura, as características clínicas e histopatológicas e sua patogênese
