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1.
Antimicrob Agents Chemother ; 53(8): 3579-81, 2009 Aug.
Article in English | MEDLINE | ID: mdl-19451292

ABSTRACT

New extended-spectrum beta-lactamase GES-11 was detected in Acinetobacter baumannii BM4674. The enzyme conferred resistance to beta-lactams, including aztreonam, and reduced susceptibility to carbapenems. The structural gene was part of a class 1 integron borne by self-transferable plasmid pIP847. GES-type beta-lactamases have not been reported previously in A. baumannii.


Subject(s)
Acinetobacter baumannii/enzymology , Acinetobacter baumannii/genetics , Anti-Bacterial Agents/pharmacology , Integrons/genetics , beta-Lactamases/genetics , beta-Lactams/pharmacology , Acinetobacter baumannii/drug effects , Aztreonam/pharmacology , Carbapenems/pharmacology , Microbial Sensitivity Tests , Models, Genetic , Molecular Sequence Data , Plasmids/genetics , beta-Lactamases/metabolism
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