ABSTRACT
Dopamine exerts an inhibitory or stimulant action on some of the hormones produced by the anterior pituitary gland. The dopamine content of the hypothalamus is considerably reduced in patients with Parkinson's disease. We have tested the anterior pituitary endocrine function in such patients to evaluate the repercussions on this function of the dopaminergic deficiency: the secretion of pituitary stimulins was found to be unaltered both at baseline level and after pharmacological stimulation.
Subject(s)
Parkinson Disease/physiopathology , Pituitary Gland, Anterior/physiopathology , Aged , Female , Humans , Male , Middle AgedABSTRACT
The influence of metabolic control on peripheral neuropathy was studied in a population of adult insulin-dependent diabetic patients. Motor conduction velocity (MCV), measured on the common peroneal nerve, was used as electrophysiological index of neuropathy. Following control of hyperglycaemia, rapid and significant improvement in MCV was observed in diabetics without renal or ocular complications, but not in diabetics presenting with these complications. This would suggest that peripheral diabetic neuropathy is governed by two different mechanisms and that one of these is metabolic, as it can be reversed by reinstating glucide balance.
Subject(s)
Diabetic Neuropathies/physiopathology , Blood Glucose/physiology , Diabetes Mellitus/metabolism , Diabetic Neuropathies/metabolism , Electromyography , Female , Humans , Insulin/therapeutic use , Male , Middle Aged , Neural ConductionABSTRACT
Five dogs and twelve rabbits were submitted to simulated diving at 6 ATA (compressed air) and 13-15 ATA (normoxic oxygen + nitrogen). Progressive decompressions were carried on for the first, rapid for the lasts. Motor nerve conduction velocity and nerve-muscle delays were measured. No variations could be observed neither for nerve conduction velocity nor for muscular and nerve action potentials. Nevertheless optic and electronic microscopy observations shew some nerve, neuronal and a few muscular alterations occuring during rapid decompression.