Peers influence the tobacco and alcohol use of Chinese adolescents.

This two-wave longitudinal study examined peer selection and influence pertaining to tobacco and alcohol use by adolescents and their friends in a sample of 854 Chinese adolescents (384 girls: mean age = 13.33 years). Participants nominated friends and self-reported their tobacco and alcohol use at seventh and again at eighth grade. Longitudinal social network analyses revealed evidence of friend influence but not selection over smoking and drinking. Boys increased their levels of smoking at rates greater than that of girls, but no sex moderation of either selection or influence was found. In interpreting these results, it is important to understand the gender norms for Chinese boys and girls and the cultural context of tobacco and alcohol use.

Nuanced Longitudinal Effects of Domains of Perceived Gender Similarity on Adolescent Peer Victimization.

Gender similarity is an indicator of perceived fit with own-gender peers and other-gender peers and is strongly correlated with indicators of adolescent adjustment, including negative peer interactions. Although gender similarity is generally studied as a composite variable, evidence is increasing that peer victimization might be uniquely related to specific domains of gender similarity such as appearance or interests. A better understanding of the specific factors that motivate peer victimization will likely aid in intervention efforts. We analyzed five domains of own- and other-gender similarity (feelings, actions, appearance, preferences, time spent with peers) for adolescents, and explored whether they uniquely predicted negative peer interactions including general peer victimization (e.g., pushing/hitting) and experiencing or perpetrating gender-based peer victimization (e.g., anti-gay name-calling) over time. With 407 adolescents (14-17 years old, M age = 15.42, 50% girls, 52% White) from two timepoints that were six months apart, we first conducted MANOVAs at T1 to assess gender differences in peer victimization experiences. Next, we conducted logistic regression path analyses to model the relation between gender similarity and peer victimization over time. Adolescents reported unique outcomes for different domains of gender similarity with girls focused on appearance and boys focused on not spending time with girls. We discuss how girls' and boys' experiences of gender similarity may be differentially informed by androcentric culture and how different expressions of gender uniquely provoke negative peer attention.

Is My Femininity a Liability? Longitudinal Associations between Girls' Experiences of Gender Discrimination, Internalizing Symptoms, and Gender Identity.

Gender discrimination is a common experience for adolescent girls and has implications for their mental health and identity development. Guided by Phenomenological Variant of Ecological Systems Theory (PVEST; Spencer et al. 1997), this study examined the longitudinal and bidirectional associations between adolescent girls' experiences of gender discrimination, their internalizing symptoms, and gender identity. The sample was 161 adolescent girls (ages 14-17; Mage = 15.90) from across the United States (51% White; 17% African American, 11% Hispanic/Latina) who participated in a short-term longitudinal study of adolescent development. The results showed a reciprocal, longitudinal association between discrimination and internalizing symptoms. Discrimination also predicted longitudinal declines in gender identity, which was explained indirectly through internalizing symptoms. The findings implicate gender discrimination as a distinct risk factor during girls' developmental years, and underscore the importance of helping girls learn adaptive responses to sexism, while also reducing actual occurrence and exposure.

A double-edged sword: Children's intergroup gender attitudes have social consequences for the beholder.

We examined the development of children's positive and negative attitudes toward other-gender peers over 1 year, and explored the longitudinal social consequences of holding positive or negative attitudes on the beholder of these attitudes. Participants were 206 second graders (Mage = 7.18 yrs, SD = .56, 50% girls) and 206 fourth graders (Mage = 9.10 yrs, SD = .66, 44.2% girls) from diverse ethnic racial backgrounds (54.6% White; 17.2% Latinx, 4.4% Black, 5.3% Asian, 2.9% Native American, .7% Pacific Islander, 13.1% other) with average household income ranged from $51,000 to $75,000, and they were assessed in 2 consecutive years. Developmental change was assessed using latent change score analysis, which showed that positive other-gender attitudes increased over time (for boys) whereas negative other-gender attitudes decreased for everyone. Path analyses showed that both positive and negative other-gender attitudes predicted children's perceptions of stressful other-gender interactions and their inclusion expectancies by other-gender peers longitudinally, controlling for same-gender attitudes. We also examined the extent to which the predicted relation between attitudes and inclusion expectancies was mediated by children's perceptions of stressful experiences with other-gender peers. We found that the extent of mediation varied by the type of attitudes and by children's age. Overall, findings contributed to the understanding of the development of children's other-gender attitudes, and underscored the consequences of these attitudes for the beholder of attitudes. This work also sheds light on the discussion of intervention strategies aimed at improving children's gender-based intergroup relations. (PsycInfo Database Record (c) 2021 APA, all rights reserved).

Parent and Peer Norms are Unique Correlates of COVID-19 Vaccine Intentions in a Diverse Sample of U.S. Adolescents.

PURPOSE: Recent studies have documented worrisome levels of hesitancy and resistance to the COVID-19 vaccine, including within the adolescent population. In this study, we examined attitudinal (perceived severity of COVID-19, vaccine-related concerns) and interpersonal (parent and peer norms) antecedents of adolescents' intentions to receive the COVID-19 vaccine. METHODS: Participants were 916 adolescents (aged 12-17 years) from across the United States (47.3% male) representing diverse ethnic and socioeconomic backgrounds (26% African-American, 22% Hispanic/Latinx, 35% white, 7% Asian American). They completed a survey on their experiences and attitudes surrounding COVID-19 and the COVID-19 vaccine. RESULTS: Parent and peer norms were distinct predictors of adolescent willingness to receive the vaccine. These norms were associated with vaccine intentions directly and indirectly through adolescents' beliefs about the vaccine's safety, efficacy, and necessity. Parent norms in particular displayed large effect sizes and explained considerable variance in adolescents' vaccine intentions. CONCLUSIONS: Parents and friends-who figure as adolescents' most salient interpersonal relationships-are key leveraging points in promoting adolescents' uptake of the COVID-19 vaccine. Norm interventions and family-based interventions may be successful in this regard.

Community development, implementation, and assessment of a NIBLSE bioinformatics sequence similarity learning resource.

As powerful computational tools and 'big data' transform the biological sciences, bioinformatics training is becoming necessary to prepare the next generation of life scientists. Furthermore, because the tools and resources employed in bioinformatics are constantly evolving, bioinformatics learning materials must be continuously improved. In addition, these learning materials need to move beyond today's typical step-by-step guides to promote deeper conceptual understanding by students. One of the goals of the Network for Integrating Bioinformatics into Life Sciences Education (NIBSLE) is to create, curate, disseminate, and assess appropriate open-access bioinformatics learning resources. Here we describe the evolution, integration, and assessment of a learning resource that explores essential concepts of biological sequence similarity. Pre/post student assessment data from diverse life science courses show significant learning gains. These results indicate that the learning resource is a beneficial educational product for the integration of bioinformatics across curricula.

Early Adolescent Gender Development: The Differential Effects of Felt Pressure from Parents, Peers, and the Self.

Most empirical research examining youth's gender development measures felt pressure to conform to gender norms using a composite value of felt pressure from multiple sources; however, because of the different socialization processes at work from parents, peers, and the self, analyzing these sources separately may elucidate different effects on gender development. Thus, the purpose of this study was to (a) differentiate the effects of perceived gender socialization pressure from parents, peers, and the self on early adolescents' own- and other-gender typicality, and (b) to examine whether a bi-directional relation between gender typicality and felt pressure is evident when distinguished across sources. With a sample of 212 early adolescents (54% girls; Mage = 11.11 years), felt pressure was found to be distinguishable by socialization source: adolescents' perceptions of parents, peers, and their own pressures were distinct, and each contributed differently to gender development. Pressure from self and peers were both found to relate concurrently to typicality (i.e., positively to own-gender typicality, negatively to other-gender typicality); only pressure from the self was found to have a longitudinal effect on adolescents' developing gender identity (i.e., an increase in own-gender typicality). Interestingly, other-gender typicality did not elicit higher felt pressure; in fact, it was negatively related to later felt pressure from the self, suggesting that adolescents may be developing self-acceptance of their levels of gender typicality. The findings suggest that the development of gender identity may involve a complex interplay with various sources of socialization pressures (e.g., parent, peers, self), and may further shift in relation to the adolescent's own levels of gender typicality.

The Influence of Peers During Adolescence: Does Homophobic Name Calling by Peers Change Gender Identity?

Adolescents actively evaluate their identities during adolescence, and one of the most salient and central identities for youth concerns their gender identity. Experiences with peers may inform gender identity. Unfortunately, many youth experience homophobic name calling, a form of peer victimization, and it is unknown whether youth internalize these peer messages and how these messages might influence gender identity. The goal of the present study was to assess the role of homophobic name calling on changes over the course of an academic year in adolescents' gender identity. Specifically, this study extends the literature using a new conceptualization and measure of gender identity that involves assessing how similar adolescents feel to both their own- and other-gender peers and, by employing longitudinal social network analyses, provides a rigorous analytic assessment of the impact of homophobic name calling on changes in these two dimensions of gender identity. Symbolic interaction perspectives-the "looking glass self"-suggest that peer feedback is incorporated into the self-concept. The current study tests this hypothesis by determining if adolescents respond to homophobic name calling by revising their self-view, specifically, how the self is viewed in relation to both gender groups. Participants were 299 6th grade students (53% female). Participants reported peer relationships, experiences of homophobic name calling, and gender identity (i.e., similarity to own- and other-gender peers). Longitudinal social network analyses revealed that homophobic name calling early in the school year predicted changes in gender identity over time. The results support the "looking glass self" hypothesis: experiencing homophobic name calling predicted identifying significantly less with own-gender peers and marginally more with other-gender peers over the course of an academic year. The effects held after controlling for participant characteristics (e.g., gender), social network features (e.g., norms), and peer experiences (e.g., friend influence, general victimization). Homophobic name calling emerged as a form of peer influence that changed early adolescent gender identity, such that adolescents in this study appear to have internalized the messages they received from peers and incorporated these messages into their personal views of their own gender identity.

Development of Expectancies About Own- and Other-Gender Group Interactions and Their School-Related Consequences.

This study examined children's expectancies about interactions with own- and other-gender peers. Goals were to examine expectancies about the outcomes related to own- versus other-gender group interactions, assess cohort and temporal changes in expectancies, and assess the effect of expectancies on school-related outcomes. Students in second and fourth grades (N = 412, 47% girls, Mage  = 7.15 and 9.10 years, respectively) were followed longitudinally for 1 year. Results supported hypotheses that social costs and inclusion-enjoyment that children expect in interactions with own- and other-gender peers represent four constructs. Expectancies varied by gender, age, and differentially predicted school outcomes with inclusion expectancies more strongly relating to outcomes than cost expectancies. Implications of children's expectancies about gendered contexts are discussed.

Perceived Parental Acceptance-Rejection and Artistic Preference: Replication Thirty Years Later / Aceptación-Rechazo Parental Percibido y Preferencias Artísticas: Replicación Treinta Años Después

Abstract: In 1982, Rohner and Frampton investigated if there is a relationship in the U.S. between the degree to which adults recall themselves as having been accepted or rejected as children and their current preference for graphic art varying in complexity of design. The researchers found a relationship between these two constructs - the participants' perceived parental acceptance in childhood was associated with a preference for more complex art forms, which differed from their expectations based on the findings of previous studies. The purpose of our study was to replicate Rohner and Frampton's (1982) work, 30 years later, in order to determine if similar findings would emerge. Among our 133 participants, perceived maternal acceptance in childhood was associated with a preference for more complex art forms [similar to Rohner and Frampton's (1982) findings]. However, our participants' perceived paternal acceptance in childhood had no association with artistic preference. We suggest that in the future, researchers work to uncover the underlying reasons for the relationship between artistic preference and perceived parental acceptance and rejection.

Resumen: En 1982, Rohner y Frampton investigaron si existe una relación en los Estados Unidos entre el grado con el que los adultos recuerdan qué tan aceptados o rechazados eran como niños y su preferencia actual sobre arte gráfico que varía en complejidad del diseño. Rohner y Frampton encontraron una relación entre estos dos constructos - la percepción de aceptación parental en la infancia se asocia con la preferencia de formas más complejas de arte, que difieren de sus expectativas, reportadas en hallazgos de investigaciones previas. El objetivo de este estudio fue replicar el trabajo de Rohner y Frampton (1982) 30 años después, para determinar si los resultados serían similares. Entre los 133 participantes, la percepción de aceptación maternal estuvo asociada con la preferencia de formas de arte más complejas [similar a lo que encontraron Rohner y Frampton (1982)]. Sin embargo, en los participantes de este estudio, la percepción de aceptación paternal durante la infancia no tuvo relación con la preferencia artística. Se sugiere que en el futuro, se trabaje en encontrar las razones subyacentes en la relación entre preferencia artística y percepción de rechazo-aceptación parental.

Alpha4beta7 integrin/MAdCAM-1 adhesion pathway is crucial for B cell migration into pancreatic lymph nodes in nonobese diabetic mice.

Although B cells are crucial antigen-presenting cells in the initiation of T cell autoimmunity to islet beta cell autoantigens in type 1 diabetes (T1D), adhesion molecules that control migration of B cells into pancreatic lymph nodes (PanLN) in the nonobese diabetic (NOD) mouse model of human T1D have not been defined. In this study, we found that B cells from PanLN of 3-4-week-old female NOD mice expressed high levels of alpha(4) integrin and LFA-1 and intermediate levels of beta(7) integrin; half of B cells were L-selectin(high). In short-term in vivo lymphocyte migration assays, B cells migrated from the bloodstream into PanLN more efficiently than into peripheral LNs. Moreover, antibodies to mucosal addressin cell adhesion molecule 1 (MAdCAM-1) and alpha(4)beta(7) integrin inhibited >90% of B cell migration into PanLN. In contrast, antibodies to peripheral node addressin, L-selectin or LFA-1 partially inhibited B cell migration into PanLN. Furthermore, one intraperitoneal injection of anti-MAdCAM-1 antibody into 3-week-old NOD mice significantly inhibited entry of B cells into PanLN for at least 2 weeks. Taken together, these results indicate that the alpha(4)beta(7) integrin/MAdCAM-1 adhesion pathway plays a predominant role in migration of B cells into PanLN in NOD mice. Thus, specific blockage of alpha(4)beta(7) integrin/MAdCAM-1 adhesion pathway-mediated B cell migration may be a potential treatment for T1D.

Contact sensitizer potassium dichromate alters lymphocyte populations in draining lymph nodes and blood in mice.

ABSTRACT Chromium is a common human contact allergen, but it is not known whether chromates cause contact hypersensitivity by immunological mechanisms similar to those induced by strong haptens. To understand the immunological events of contact hypersensitivity to chromates, we investigated whether and how chromate sensitization alters lymphocyte subsets in draining lymph nodes (DLNs), blood, and spleens in mice. BALB/c mice were sensitized by painting their ears with 0.5% potassium dichromate or vehicle alone on 3 consecutive days. Flow cytometric analysis of lymphocyte surface antigens showed that the chromate exposure significantly increased the percentage of B cells and decreased the percentages of T cells in the DLNs. This was accompanied by a relative increase in T cells and a relative decrease in B cells in peripheral blood. In contrast to the chromate, sodium dodecyl sulfate (a skin irritant) did not affect B cells or T cells in the three compartments. Moreover, sensitization to the chromate led to dose-dependent decreases in the percentages of CD4(+) T cells and CD8(+) T cells in the DLNs. However, CD4(+) and CD8(+) memory T cells were significantly increased in the blood and DLNs of the chromate-sensitized mice. Additionally, the percentage of B cells in the DLNs but not blood was dose-dependently increased in the chromate-sensitized mice. Histologically, B-cell areas were dramatically enlarged in the DLNs of the chromate-sensitized mice. Thus, this report provides basic information to further elucidate the role of individual lymphocyte subsets in contact hypersensitivity to chromates.