Subject(s)
Antineoplastic Agents, Immunological/adverse effects , Antineoplastic Combined Chemotherapy Protocols/adverse effects , Immunotherapy/adverse effects , Melanoma/drug therapy , Panuveitis/chemically induced , Uveitis, Anterior/chemically induced , Aged , Antibodies, Monoclonal, Humanized/adverse effects , Electroretinography , Female , Humans , Incidence , Ipilimumab/adverse effects , Male , Melanoma/secondary , Nivolumab/adverse effects , Northern Ireland/epidemiology , Panuveitis/diagnostic imaging , Panuveitis/epidemiology , Panuveitis/physiopathology , Retina/physiopathology , Tomography, Optical Coherence , Uveitis, Anterior/diagnostic imaging , Uveitis, Anterior/epidemiology , Uveitis, Anterior/physiopathology , Visual Acuity/physiologyABSTRACT
Choroidal melanoma is the commonest adult primary intraocular tumour,1 and usual sites of secondary spread are to liver, bone and lung. Although delayed recurrence of ipsilateral orbital melanoma is well documented, metastasis to the contralateral orbit is a rarely encountered phenomenon. We describe a case of metastatic spread to the contralateral orbit in a patient 12 years after proton beam radiotherapy of choroidal melanoma.
ABSTRACT
We report a case of true exfoliation of the crystalline lens in a 53-year-old baker who presented with reduced vision due to cataract. Phacoemulsification cataract surgery with intraocular lens implantation was performed, and the anterior capsule was analyzed histologically. Preoperative clinical and anterior segment optical coherence tomography observations are presented, with a description of the modified phacoemulsification technique and histopathology. A possible mechanism of pathogenesis is proposed in the context of the histopathology.
Subject(s)
Cataract/etiology , Exfoliation Syndrome/complications , Lens Capsule, Crystalline/pathology , Phacoemulsification/methods , Cataract/diagnosis , Epithelial Cells/pathology , Exfoliation Syndrome/diagnosis , Humans , Lens Implantation, Intraocular , Male , Middle Aged , Tomography, Optical CoherenceSubject(s)
Cryosurgery/methods , Retinal Detachment/surgery , Humans , Laser Coagulation , Recurrence , Visual AcuityABSTRACT
PURPOSE: To demonstrate differences in human lens epithelial cell adhesion to different intraocular lens biomaterials in vitro and to determine whether these differences can be influenced by coating the intraocular lens surface with commercially available fibronectin. METHODS: A prospective laboratory-based study comparing human lens epithelial cell adhesion to silicone (n=18), polymethylmethacrylate (PMMA; n=18), and acrylic (n=18) intraocular lenses in vitro. The three types of intraocular lenses were then coated with fibronectin: silicone (n=6), PMMA (n=6), and acrylic (n=6). The main outcome measure was the mean number of lens epithelial cells attached to each lens type after 24 hours of incubation. RESULTS: In the uncoated lens group, there was a significantly higher number of lens epithelial cells attached to the acrylic than to the silicone or PMMA lenses (P<0.001). Coating the lenses with fibronectin caused a significant increase in attachment of lens epithelial cells for all three lens types. CONCLUSIONS: There was a significant difference in the degree of lens epithelial cell attachment to the various types of intraocular lenses in vitro. Cell attachment was more prominent in the acrylic lenses, but the fibronectin coating negated differences in lens type and caused a significant increase in cell attachment across all groups.
