ABSTRACT
Synovial sarcoma is an uncommon neoplasm that usually arises in the extremities and rarely in the head and neck. A case arising in the neck has been reported herein. The tumor is composed of two intimately associated cellular patterns; one resembles synovial structures and the other resembles fibrosarcoma. The tumor is fairly slow growing and is fairly well circumscribed but not actually encapsulated. There is a predilection for males; most occur in the third through fifth decades of life. Recurrence follows inadequate therapy. Although local excision was the therapy used in this case, the patient is alive and free of disease 30 months postoperatively.
Subject(s)
Head and Neck Neoplasms/pathology , Sarcoma, Synovial/pathology , Adult , Head and Neck Neoplasms/etiology , Head and Neck Neoplasms/surgery , Humans , Male , Prognosis , Sarcoma, Synovial/etiology , Sarcoma, Synovial/surgerySubject(s)
Maxillofacial Injuries/complications , Adult , Catheterization/adverse effects , Catheterization/instrumentation , Enteral Nutrition/instrumentation , Female , Humans , Injections, Intravenous/adverse effects , Jugular Veins , Mandibular Fractures/complications , Mandibular Fractures/surgery , Postoperative Complications , Subclavian VeinSubject(s)
Amino Acids/metabolism , Liver/metabolism , Ribosomes/metabolism , Adenosine Triphosphate , Animals , Bile Acids and Salts , Buffers , Carbon Isotopes , Chromatography, Gel , Detergents , Glutathione , Hydrogen-Ion Concentration , Magnesium , Male , Methods , Osmolar Concentration , Piperazines , Potassium , Rats , Sulfonic Acids , TemperatureSubject(s)
Cell Nucleus , Liver/cytology , Aging , Animals , DNA/analysis , Electronics, Medical , Male , Methods , RNA/analysis , RatsABSTRACT
Weanling (23-day-old) rats were fed either on an amino acid-deficient diet (6% of casein, which in effect represents an ;amino acid-deficient' diet) or on a diet containing an adequate amount of protein (18% of casein) for 28 days. The hepatic cells from the animals fed on the low-protein diet were characterized by low amino acid content, almost complete inhibition of cell proliferation and a marked decrease in cell volume, protein content and concentration of cytoplasmic RNA compared with cells from control rats. The lower concentration of cytoplasmic RNA was correlated with a decreased ribosomal-RNA content, of which a larger proportion was in the form of free ribosomes. The protein-synthetic competence and messenger-RNA content of isolated ribosomes from liver cells of protein-deprived animals were 40-50% of those noted in controls. At 1hr. after an injection of radioactive uridine, the specific radioactivity of liver total RNA was greater in the group fed on the low-protein diet, but the amount of label that was associated with cytoplasmic RNA or ribosomes was significantly less than that noted in control animals. From these data it was concluded that dietary amino acids regulate hepatic protein synthesis (1) by affecting the ability of polyribosomes to synthesize protein and (2) by influencing the concentration of cytoplasmic ribosomes. It is also tentatively hypothesized that the former process may be directly related to the concentration of cellular free amino acids, whereas the latter could be correlated with the ability of newly synthesized ribosomal sub-units to leave the nucleus.
