Converging crises: public interest journalism, the pandemic and public health.

Public interest journalism has faced a longstanding funding crisis, cutbacks of staff and resources, and closures of newsrooms. This crisis is a critical public health concern, and it has been exacerbated by the COVID-19 pandemic. At the same time, the pandemic has highlighted the important roles played by public interest journalism - including in addressing health equity issues. The pandemic has also highlighted the need to address structural weaknesses in the media industry, with concentration of media ownership and underfunding of public broadcasters leading to many communities being under-served and under-represented. The public health sector can make important contributions to developing and sustaining a robust, public interest journalism sector. Public health professionals and organisations can advocate for policy reform to support public interest journalism, and incorporate consideration of public interest journalism into advocacy, education, research and practice.

An update of Wnt signalling in endometrial cancer and its potential as a therapeutic target.

Endometrial cancer is the most common gynaecological malignancy in developed nations, and its prevalence is rising as women defer or decide not to have children and as obesity rises, both key risk factors. Despite this, treatment options remain limited, particularly for advanced or refractory disease. New genomic analyses have revealed distinct mutational profiles with therapeutic and prognostic potential. Wnt signalling, which is pivotal in embryogenesis, healing and homeostasis, is of importance in the endometrium and has been linked to carcinogenesis. This review aims to update and discuss the current evidence for the role of ß-catenin dependent and independent Wnt signalling, including the ROR receptors in the endometrium and its potential as a therapeutic target, in light of recent trials of Wnt-targeted therapy in multiple tumour types.