1.
Bioorg Med Chem Lett
; 9(10): 1453-8, 1999 May 17.
Article
in English
| MEDLINE
| ID: mdl-10360755
ABSTRACT
A novel series of 13- and 14-membered macrocyclic amines was developed by linking the P1 and P2' groups. The synthesis entails stereoselective Frater alkylation to install the anti-succinate configuration and macrocyclic amination via nucleophilic displacement. This strategy resulted in a new class of conformationally constrained inhibitors that are potent and selective for MMP-8 and 9 over MMP-1 and 3.
Subject(s)
Amines/pharmacology , Extracellular Matrix/enzymology , Metalloendopeptidases/antagonists & inhibitors , Protease Inhibitors/pharmacology , Amines/chemistry , Computer Simulation , Models, Molecular , Protease Inhibitors/chemistry
2.
J Endod
; 6(7): 655-6, 1980 Jul.
Article
in English
| MEDLINE
| ID: mdl-6935375