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1.
United European Gastroenterol J ; 5(7): 1046-1050, 2017 Nov.
Article in English | MEDLINE | ID: mdl-29163972

ABSTRACT

BACKGROUND: The prevalence of gastrointestinal involvement in systemic sclerosis is higher than 75%. The estimated prevalence of fecal incontinence varies from 22% to 77%, but suffers from recruitment bias and patient reluctance. Our goal was to evaluate the prevalence of fecal incontinence in systemic sclerosis, and to identify associated risk factors. METHODS: Patients were recruited in the referral systemic sclerosis network of the Lyon University Hospitals, using self-administered questionnaires including constipation, fecal incontinence and Bristol Stool scales, quality of life, anxiety and depression. The cohort was compared with the historical ORALIA cohort that established the prevalence of fecal incontinence in the general population of the Rhône-Alpes region (France). RESULTS: Seventy-seven patients were included (mean age: 60 years, range: 32-84), and 86% were female. These were compared to 153 ORALIA individuals matched for age and sex. Fecal incontinence was present in 38% of patients and 6% of the general population. A longer duration of systemic sclerosis was the only characteristic associated with fecal incontinence. Abnormal stool consistency was more frequent in patients with fecal incontinence. CONCLUSION: Fecal incontinence and abnormal stool consistency are common in systemic sclerosis and should be systematically addressed.

2.
Transpl Infect Dis ; 18(4): 606-10, 2016 Aug.
Article in English | MEDLINE | ID: mdl-27224849

ABSTRACT

Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the central nervous system caused by the JC polyomavirus (JCPyV) in immunocompromised patients, including solid organ transplant recipients. We report 2 cases of PML late after liver transplantation (144 and 204 months) and review the few other published cases. The clinical course of PML is characterized by a rapid progressive neurological decline coinciding with the presence of white matter lesions on magnetic resonance images. No direct antiviral therapy is available against the JCPyV. The prognosis is therefore extremely poor. Restoration of the immune response achieved by tapering or ending the immunosuppressive therapy is the basis of treatment in transplanted patients. One of our patients is alive 3 years after diagnosis after total withdrawal of immunosuppressive therapy. The other presented severe rejection when tapering immunosuppression and died 26 months after diagnosis.


Subject(s)
Graft Rejection/drug therapy , Immunocompromised Host , Immunosuppression Therapy/adverse effects , JC Virus/isolation & purification , Leukoencephalopathy, Progressive Multifocal , Liver Transplantation/adverse effects , Adrenal Cortex Hormones/administration & dosage , Adrenal Cortex Hormones/adverse effects , Adrenal Cortex Hormones/therapeutic use , Adult , Cerebral Cortex/diagnostic imaging , Fatal Outcome , Female , Humans , Immunosuppression Therapy/methods , Immunosuppressive Agents/administration & dosage , Immunosuppressive Agents/adverse effects , Immunosuppressive Agents/therapeutic use , Leukoencephalopathy, Progressive Multifocal/cerebrospinal fluid , Leukoencephalopathy, Progressive Multifocal/diagnostic imaging , Leukoencephalopathy, Progressive Multifocal/virology , Magnetic Resonance Imaging , Male , Prognosis , Withholding Treatment
3.
Rev Med Interne ; 36(11): 773-6, 2015 Nov.
Article in French | MEDLINE | ID: mdl-25623510

ABSTRACT

INTRODUCTION: Sarcoidosis is a systemic granulomatous disorder of unknown aetiology. It may rarely affect the gastrointestinal tract. CASE REPORT: We reported a 54-year-old woman with a delayed diagnosis of duodenal sarcoidosis. She presented with gastric and right upper abdominal pain associated with vomiting and marked weight loss. Abdominal computed tomographic scan showed non-compressive retroperitoneal lymph nodes and histological examination revealed non-caseating epithelioid granulomas typical of sarcoidosis. Diagnosis of duodenal sarcoidosis was obtained at the third gastroscopy. The patient's condition improved quickly with corticosteroid therapy. CONCLUSION: Gastrointestinal sarcoidosis should be looked for in patients with digestive symptoms and another sarcoid localisation. Furthermore, it is important to repeat gastroscopy to confirm diagnosis because treatment improved most patients.


Subject(s)
Duodenal Diseases/diagnosis , Sarcoidosis/diagnosis , Abdominal Pain/etiology , Female , Gastroscopy , Humans , Middle Aged , Vomiting/etiology , Weight Loss
4.
Ann Fr Anesth Reanim ; 30(7-8): 578-88, 2011.
Article in French | MEDLINE | ID: mdl-21454034

ABSTRACT

OBJECTIVES: Present the clinical signs of bradykinin-mediated angioedema, a disease little known to intensive care anaesthesiologists, and develop their scientific basis with recent data on management in emergency and perioperative care. DATA SOURCES: International recommendations and recent general reviews. Data collection was performed using the Medline database with the keyword: angioedema. STUDY SELECTION AND DATA EXTRACTION: Research studies published during the last 10 years were reviewed. Relevant clinical information was extracted and discussed. DATA SYNTHESIS: Angioedema is a clinical syndrome characterized by episodes of transitory recurrent submucosal and subcutaneous oedema, called attacks. During an attack, the oedema may be localized at the level of the skin and/or ENT and digestive tract mucosa. This syndrome is not due to an allergic reaction. It is related to a C1 complement inhibitor deficiency or an increase in factor XII resulting in the excessive release of bradykinin, which leads to capillary permeability. There are hereditary and acquired forms, notably associated with the use of ACE inhibitors and sartans. This rare disease should be recognized by anaesthesiologists and intensive care and emergency physicians because, in the absence of specific treatment, it can be life-threatening due to the appearance of laryngeal oedema. In addition, there is a risk that the patient may have an attack during the perioperatory period, due to surgical trauma. International recommendations exist, and there are new molecules available in France. For moderate attacks, treatment is based on tranexamic acid. For hereditary forms, according to the localization and gravity of the attacks, emergency treatment is based on the use of Icatibant, a bradykinin B2 receptor inhibitor, and C1 inhibitor concentrate. For pregnant women and acquired forms, C1 inhibitor concentrate is the treatment of reference. Antalgic and perfusion treatments should not be neglected, and should be modified as a function of clinical signs. High-risk situations (perioperatory period, birthing, dental care) should be identified and short-term prophylaxis put in place before any procedure that may trigger an attack. Algorithms are proposed for the diagnosis, treatment and prevention of attacks. Recommendations exist for during childbirth, in which case C1 inhibitor concentrate should be used. CONCLUSION: Bradykinin-mediated angioedema should be evoked in the case of recurrent and transitory oedema. Emergency management has evolved thanks to the commercialization of new molecules. Prevention of attacks during surgery and for during childbirth is important. The availability of C1 inhibitor concentrate in sufficient doses should be verified prior to the procedure. A multi-site reference centre (CREAK) has been created to help clinicians manage this disease. Patients with this disease should be identified in emergency departments. Health establishments, which cannot all have emergency stocks, should set up procedures for rapid provision or the transfer of patients to reference sites.


Subject(s)
Angioedema/diagnosis , Angioedema/therapy , Bradykinin/physiology , Algorithms , Angioedema/etiology , Emergency Treatment , Humans , Severity of Illness Index
5.
Rev Med Interne ; 30(9): 812-5, 2009 Sep.
Article in French | MEDLINE | ID: mdl-19193475

ABSTRACT

Alveolar echinococcosis (AE) is a rare but potentially serious zoonosis for which an early diagnosis is of primary importance. We report the first observation of AE in a cardiac transplant patient infected by hepatitis C virus. He first presented with a single asymptomatic hepatic nodule. The liver biopsy showed an epithelioid granuloma with necrosis. We review the clinical features, diagnosis and outcome of this disease in immunocompromised hosts. In immunocompromised patients living in areas endemic for Echinococcus multilocularis, AE should be included in the differential diagnosis of tumor like lesions of the liver.


Subject(s)
Echinococcosis, Hepatic/immunology , Echinococcus multilocularis , Granuloma/immunology , Heart Transplantation , Hepatitis C/complications , Immunocompromised Host , Liver Diseases/immunology , Adult , Animals , Biopsy , Diagnosis, Differential , Echinococcosis, Hepatic/complications , Echinococcosis, Hepatic/diagnosis , Echinococcosis, Hepatic/pathology , Granuloma/complications , Granuloma/pathology , Hepatitis C/immunology , Humans , Liver/pathology , Liver Diseases/complications , Liver Diseases/pathology , Male , Necrosis , Zoonoses
6.
Rev Med Interne ; 30(12): 1038-43, 2009 Dec.
Article in French | MEDLINE | ID: mdl-18585827

ABSTRACT

INTRODUCTION: Current unusual environmental sources of lead exposure mainly include traditional medicines, either ayurvedic remedies or others, traditional cosmetics (kohl, surma), and the use of traditional earthenware, for storage or cooking. CASE REPORTS: We report two cases of lead poisoning in adults initially identified by paroxysmal abdominal pain or anemia. In both cases, the environmental investigation evidenced one main source of lead exposure, namely a lead-glazed earthenware jug in which a drink was stored, "kefir" in the first case, and "kombucha" tea in the second one. CONCLUSION: It is recommended to search for lead intoxication in patients with unexplained anemia. Environmental sources of lead can be multiple. Their relative importance has to be ranked during the environmental investigation and among these, lead-glazed earthenware must be considered as a source of high lead exposure when drinks are stored inside and thus can soak.


Subject(s)
Beverages , Ceramics/adverse effects , Ceramics/chemistry , Cooking and Eating Utensils , Food Contamination/analysis , Lead Poisoning/etiology , Abdominal Pain/chemically induced , Adult , Anemia/chemically induced , Chelating Agents/therapeutic use , Cultured Milk Products , Edetic Acid/therapeutic use , Environmental Exposure/adverse effects , Female , Humans , Lead Poisoning/complications , Lead Poisoning/diagnosis , Lead Poisoning/drug therapy , Male , Middle Aged , Tea , Treatment Outcome
7.
Rev Med Interne ; 28(11): 731-6, 2007 Nov.
Article in French | MEDLINE | ID: mdl-17597259

ABSTRACT

INTRODUCTION: Equivalence trials are actually frequently used to prove non-inferiority in anticoagulant therapy. Equivalence trials consist to demonstrate that two treatments are not too much different. This difference has to be under a margin previously determined. The margin corresponds to an efficacy loss that is defined to be acceptable, in accordance to the advantages due to the new treatment. The aim of this work is to explore the equivalence trial published in the thromboembolic disease by focus on the non-inferiority margin used. METHODS: We identified published equivalence trials in the venous thromboembolic disease, by a systematic search in Medline. We calculated the efficacy loss by reference with the value of the smallest effect size of the standard treatment compared to placebo. RESULTS: We found 9 equivalence trials used in venous thromboembolic disease. The mean value of the efficacy loss was 434%, and the median value was 357%. Eighty-five percent of the values of the efficacy loss were above 100%. DISCUSSION: Eighty-five percent of the equivalence trials conclude to equivalence despite a complete efficacy loss of the effect of the standard treatment compared to placebo. The results of equivalence trials should be interpreted warily. The corresponding non-inferiority margin should be chosen more rigorously and by reference with the value of the smallest effect size of the standard treatment compared to placebo.


Subject(s)
Anticoagulants/therapeutic use , Therapeutic Equivalency , Thromboembolism/drug therapy , Clinical Trials as Topic , Dose-Response Relationship, Drug , Heparin/therapeutic use , Treatment Outcome
10.
Rev Neurol (Paris) ; 152(10): 642-5, 1996 Oct.
Article in French | MEDLINE | ID: mdl-9033960

ABSTRACT

The Romano-Ward syndrome shows a congenital prolonged QT on the electrocardiogram. It is often revealed by syncopes, sudden death and, in rare cases, by an epileptic attack. We report the cases of two sisters presenting this syndrome. One of them presented an inaugural epileptic attack. The electrocardiogram returned to normal and the seizures disappeared after a treatment with beta-bloquants.


Subject(s)
Epilepsy/genetics , Long QT Syndrome/genetics , Adult , Epilepsy/etiology , Female , Humans , Long QT Syndrome/complications , Long QT Syndrome/physiopathology
11.
J Mal Vasc ; 21(1): 22-30, 1996.
Article in French | MEDLINE | ID: mdl-8656087

ABSTRACT

The sensitivity and specificity of an ELISA method (Fibrinostika Fbdp Organon Teknika) for assay of D-dimers in the diagnosis of deep vein thrombosis and/or pulmonary embolism was studied in 80 consecutive patients seen at an emergency unit. Fifty-six of the patients presented clinical signs of deep vein thrombosis. Diagnosis was confirmed in 26 of the 56 patients with a D-dimer level above 370 ng/ml (sensitivity 92.3%) and 370 ng/ml for 13 of 30 patients with a negative venous ultrasound Doppler examination (specificity 43.3%). The positive predictive value was 58.5% and the negative predictive value was 87%. There was a significant difference in the level of D-dimers between distal and proximal deep vein thrombosis. In 40 cases with suspected pulmonary embolis, either alone or with suspected deep vein thrombosis, diagnosis was made in only 4 of 9 with a highly or intermediately probable ventilation/perfusion scan. D-dimer level was always above 3,000 ng/ml. Coupling the ELISA dimer test with noninvasive explorations improves negative predictive value but can also avoid invasive explorations (venography, pulmonary angiography) in certain patients. A D-dimer test as sensitive as the ELISA test and as rapid as the latex test remains to be described.


Subject(s)
Enzyme-Linked Immunosorbent Assay , Fibrin Fibrinogen Degradation Products/analysis , Pulmonary Embolism/diagnosis , Thrombophlebitis/diagnosis , Adolescent , Adult , Aged , Aged, 80 and over , Female , Humans , Male , Middle Aged , Predictive Value of Tests , Prospective Studies , Sensitivity and Specificity
13.
Presse Med ; 24(30): 1381-5, 1995 Oct 14.
Article in French | MEDLINE | ID: mdl-8545315

ABSTRACT

Type IV Ehlers-Danlos syndrome, a rare disease caused by abnormal synthesis of type III collagen, often leads to vascular fragility. We report 9 cases (6 men and 3 women, mean age 35 years). For 7 of the patients, the inaugural signs were arterial complications including haemoperitoneum in 2 patients with multiple aneurysmal dystrophy of the abdominal arteries, one case of ruptured subclavian artery, two dissections of the renal artery, one case with rupture of a cerebral aneurysm, one rupture of the mesenteric artery and a haematoma after arterial puncture. Other vascular manifestations were acrosyndrome (n = 4), varicose veins (n = 3), and prolapsus of the mitral valve (n = 2). In addition, 8 of the 9 patients presented extravascular signs. There was a history of familial disease in 5 cases. Pregnancy was completed to term in three patients: a cesarean section was required in one case and intra-uterine growth retardation was seen in 2. Morbidity was important with hemiparesia, blindness and paraparesis sequellae. One patient died from haemorrhage. This series of patients with type IV Ehlers-Danlos syndrome illustrates the severity of this disease whose prevalence is often underestimated. The disease is transmitted by autosomal dominant inheritance, underscoring the importance of familial testing for early diagnosis. Clinicians should be aware of the vascular manifestations and avoid invasive punctures or operations except in exceptional indications.


Subject(s)
Cardiovascular Diseases/etiology , Ehlers-Danlos Syndrome/complications , Adult , Cardiovascular Diseases/diagnostic imaging , Cardiovascular Diseases/surgery , Ehlers-Danlos Syndrome/genetics , Ehlers-Danlos Syndrome/pathology , Female , Humans , Intracranial Aneurysm/etiology , Intracranial Aneurysm/surgery , Male , Middle Aged , Mitral Valve Prolapse/etiology , Mitral Valve Prolapse/surgery , Radiography , Raynaud Disease/etiology , Raynaud Disease/surgery
15.
Rev Prat ; 45(1): 56-61, 1995 Jan 01.
Article in French | MEDLINE | ID: mdl-7725010

ABSTRACT

An atheromatous aorta may be the source of micro-emboli composed of cholesterol crystals. These cholesterol emboli presumably result from dislodgment of atheromatous material occurring either spontaneously, or consecutively to a coronary angiography, an aortic surgery or even an anticoagulant or thrombolytic treatment. Even if the best known clinical feature is the "blue toe" syndrome together with renal insufficiency, the spectrum of disease caused by cholesterol emboli ranges from asymptomatic to rapidly progressive multiple system failure. Therefore cholesterol embolism is a serious complication of aortic atherosclerosis and often holds a poor prognosis. Diagnosis is confirmed by skin or muscle biopsy and fundoscopic examination. The optimal treatment remains to be established.


Subject(s)
Arteriosclerosis/complications , Embolism, Cholesterol , Leg/blood supply , Aged , Embolism, Cholesterol/diagnosis , Embolism, Cholesterol/etiology , Embolism, Cholesterol/pathology , Embolism, Cholesterol/therapy , Humans
20.
Thromb Res ; 73(3-4): 185-92, 1994 Feb 15.
Article in English | MEDLINE | ID: mdl-8191412

ABSTRACT

Gammacarboxyglutamic acid (gla) is a non essential amino acid synthesized in presence of vitamin K, predominantly found in coagulation and bone proteins. In 14 cases of deep vein thrombosis and in 11 cases of disseminated intravascular coagulation, compared to 19 normal subjects and 9 patients hospitalized for leg pain, free plasma gla levels were found significantly elevated (respectively 372 +/- 244 and 559 +/- 361 versus 146 +/- 34 and 120 +/- 40 pmol/mL). In six paired plasma and serum, gla levels were similar. These results suggest an involvement of blood coagulation in gla generation with need of a catabolism of the activated factors. A significant decrease was noticed during vitamin K antagonist therapy and liver disease, both instances in which the synthesis of gla containing coagulation factors is affected. During hepatocellular carcinoma with elevated desgamma carboxyprothrombin, gla was found normal, denying an global impairement of the vitamin K metabolism.


Subject(s)
1-Carboxyglutamic Acid/blood , Disseminated Intravascular Coagulation/blood , Pulmonary Embolism/blood , Thrombophlebitis/blood , Adolescent , Adult , Aged , Aged, 80 and over , Biomarkers/blood , Carcinoma, Hepatocellular/blood , Chronic Disease , Female , Hemangioma/blood , Humans , Leg , Liver Diseases/blood , Liver Neoplasms/blood , Male , Middle Aged , Pain/blood , Skin Neoplasms/blood , Vitamin K/antagonists & inhibitors
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