ABSTRACT
Two patients who underwent breast conservation including radiotherapy for early breast carcinoma are described and who subsequently delivered healthy newborn infants. One of the two patients lactated from both the irradiated and the non-irradiated breast; whereas the other patient did not lactate from the irradiated side. The treatment and implications are discussed.
Subject(s)
Breast Neoplasms/radiotherapy , Breast/radiation effects , Lactation/radiation effects , Adult , Breast Neoplasms/physiopathology , Female , Humans , PregnancyABSTRACT
A patient is described with invasive squamous carcinoma developing in one cervix in a didelphic uterus with double cervix and vagina completely separated by a vaginal septum.
Subject(s)
Carcinoma, Squamous Cell/pathology , Cervix Uteri/abnormalities , Uterine Cervical Neoplasms/pathology , Female , Humans , Middle AgedABSTRACT
A double-blind trial of the tanned-erythrocyte electrophoretic mobility test for cancer has been carried out. This included 70 normal subjects as controls, 61 subjects with disease other than cancer, and 229 cancer patients. Slowing values generally increased in the order given, with certain diseases having values within the range positive for cancer. Exposure to viral infection also tended to produce false positives. Slowing values above 50%, however, appear to be definitely associated with cancer. For the middle range of slowing values (25-50%) there is some overlap between the 3 groups, so that a statistical probability of the presence of malignancy is available from the test. With slowing values below 25% there is little likelhood of cancer. Tumour type influences the test result, as does, to a lesser extent, tumour bulk.
Subject(s)
Erythrocytes , Lymphocytes/immunology , Lymphokines/analysis , Macrophage Migration-Inhibitory Factors/analysis , Neoplasms/diagnosis , Adult , Aged , Breast Neoplasms/diagnosis , Bronchial Neoplasms/diagnosis , Carcinoma, Basal Cell/diagnosis , Carcinoma, Squamous Cell/diagnosis , Double-Blind Method , Electrophoresis , Female , Humans , Middle AgedABSTRACT
We have determined that when an extract of human brain is preincubated with lymphocytes its subsequent capacity to inhibit the electrophoretic mobility of tanned and stabilized erythrocytes is much reduced. There is a differential effect, however, as the observed reduction is from 73% inhibition to approximately 35% when the pre-incubation is with lymphocytes from patients with malignant disease, but from 73% to approximately 10% when it is with lymphocytes from normal controls. These values were obtained at a brain extract concentration of 333 microgram/ml, with 5 times 10(6) lymphocytes, a pre-incubation time of 18-24 h, and a temperature of 27 degrees C, which are the optimum conditions determined for differentiation between cancer patients and normal subjects. In a series of 73 subjects tested by this method 43/51 cancer patients gave an unequivocal "positive" value, 22/22 normal controls gave a "negative" value, with no false positives.
Subject(s)
Erythrocytes , Lymphocytes/immunology , Neoplasms/diagnosis , Adult , Brain , Electrophoresis , Female , Humans , Leukocyte Count , Male , Middle Aged , Neoplasms/immunology , Proteins , Temperature , Time Factors , Tissue ExtractsABSTRACT
A 29-year-old man had abdominal pain for 24 hours. This and the results of an abdominal examination were typical of acute appendicitis. He had suffered sinusitis for two weeks. At operation, the appendix was normal; there was an abscess in the cecal wall, the exudate of which grew pneumococci. Incidental appendectomy was done and the patient was treated successfully with lincomycin hydrochloride, and later, cephalexin monohydrate. It is possible that the typhlitis was secondary to the upper respiratory infection.
