FN400 and LPC memory effects for concrete and abstract words.

According to dual-process models, recognition memory depends on two neurocognitive mechanisms: familiarity, which has been linked to the frontal N400 (FN400) effect in studies using ERPs, and recollection, which is reflected by changes in the late positive complex (LPC). Recently, there has been some debate over the relationship between FN400 familiarity effects and N400 semantic effects. According to one view, these effects are one and the same. Proponents of this view have suggested that the frontal distribution of the FN400 could be due to stimulus concreteness: recognition memory experiments commonly use highly imageable or concrete words (or pictures), which elicit semantic ERPs with a frontal distribution. In the present study, we tested this claim using a recognition memory paradigm in which subjects memorized concrete and abstract nouns; half of the words changed font color between study and test. FN400 and LPC old/new effects were observed for abstract as well as concrete words, and were stronger over right hemisphere electrodes for concrete words. However, there was no difference in anteriority of the FN400 effect for the two word types. These findings challenge the notion that the frontal distribution of the FN400 old/new effect is fully explained by stimulus concreteness.

Abnormal event-related potentials in young and middle-aged adults with the ApoE ε4 allele.

The largest genetic susceptibility factor for Alzheimer's disease is the Apolipoprotein E (ApoE) ε4 allele. Cognitive decline and olfactory impairment are greater in those positive for the ε4 allele. This study sought to determine if the olfactory event-related potential (OERP), compared to the visual ERP, would be sensitive to these subtle declines. Participants included 40 individuals from two age groups, half of each group were ε4 allele positive and half were ε4 negative. Visual ERPs did not demonstrate significant differences between ApoE groups. OERPs demonstrated robust age by ApoE interactions. P3 latencies were significantly longer in ε4 young and middle age participants. These findings suggest that very early olfactory and cognitive changes related to ApoE status are detectible via the OERP.

The enduring effect of availability.

The present study addressed whether experienced ease of retrieval of autobiographical events affects trait judgments made immediately and after a delay (Experiment 1) and whether this influence is modulated by either of two discounting instructions (Experiment 2). In Experiment 1, participants first attempted to retrieve 6 or 12 personal memories for different traits and then made ease of retrieval and self-trait judgments immediately or 1 week later. In Experiment 2, participants made immediate ratings and then delayed ratings under 3 instructional manipulations: a generic instruction to repeat these judgments, to make these ratings after they were reminded of their original recall total, or to make these ratings after they had their retrieval ease discounted or augmented. In each experiment, an enduring effect of availability was obtained in that the relationship between ease of retrieval and self-trait rating was only slightly affected by the delay. Being reminded of the original number of recalled memories nullified the relationship between ease of retrieval and trait rating. However, discounting or augmenting ease of retrieval, which altered ease of retrieval ratings, did not. Potential explanations for an enduring effect of availability are discussed.