ABSTRACT
Research on cardiac progenitor cell populations has generated expectations about their potential for cardiac regeneration capacity after acute myocardial infarction and during physiological aging; however, the endogenous capacity of the adult mammalian heart is limited. The modest efficacy of exogenous cell-based treatments can guide the development of new approaches that, alone or in combination, can be applied to boost clinical efficacy. The identification and manipulation of the adult stem cell environment, termed niche, will be critical for providing new evidence on adult stem cell populations and improving stem-cell-based therapies. Here, we review and discuss the state of our understanding of the interaction of adult cardiac progenitor cells with other cardiac cell populations, with a focus on the description of the B-CPC progenitor population (Bmi1+ cardiac progenitor cell), which is a strong candidate progenitor for all main cardiac cell lineages, both in the steady state and after cardiac damage. The set of all interactions should be able to define the vascular cardiac stem cell niche, which is associated with low oxidative stress domains in vasculature, and whose manipulation would offer new hope in the cardiac regeneration field.
ABSTRACT
Evaluación del Programa de Mejoramiento de Servicios de Salud México-BID 1991, aplicado en México por la Secretaría de Salud, donde se dan a conocer los resultados en materia de: I. Población y cobertura II. Disponibilidad de recursos III. Productividad IV. Segundo Nivel de Atención V. Satisfacción del usuario VI. Organización y participación comunitaria VII. Construcción y equipamiento de unidades VIII. Disponibilidad de servicios básicos y condiciones de las unidades IX. Financiamiento X. Conservación y mantenimiento XI. Comentarios y conclusiones
