ABSTRACT
INTRODUCCIÓN: Es una patología infrecuente del descenso testicular, a la fecha en la literatura sólo se han reportado aproximadamente 100 casos. Afecta por lo general a varones de 1-2 años de edad. El diagnóstico en adultos es sumamente raro. OBJETIVO: Describir las características clínicas de un caso de ectopia testicular cruzada unilateral. CASO CLÍNICO: Paciente varón de 35 años de edad, consulta por tumoración en región inguinal izquierda de un 1 año de evolución, que desaparece al decúbito dorsal y aumenta de tamaño con el esfuerzo (estornudo y defecación). Niega dolor, edema, detención de heces y gases. Al examen físico de la región inguinal de pie se aprecia una tumoración de forma ovoidea, asimétrica desde anillo superficial hasta las bolsas escrotales del mismo lado; en decúbito dorsal se aprecia una tumoración de forma ovoidea, blanda, renitente, reductible e incoercible, por arriba del ligamento de Poupart y desde el orificio inguinal profundo-externo, se palpa testículo y epidídimo de forma y tamaño normal, RHA (+), transiluminación (-). La impresión diagnóstica indica hernia inguinal indirecta. Durante la disección y reparo del cordón se constata la presencia del doble paquete vascular correspondiente a ambos testículos exteriorizados a través del orificio inguinal profundo izquierdo. DISCUSIÓN: Esta rara patología es diagnosticada de forma casual en la mayoría de los casos, como hallazgo operatorio en pacientes diagnosticados de hernia inguinal o criptorquidia.
INTRODUCTION: It is a rare pathology of testicular descent, to the date the literature has reported only a hundred cases. Usually it affects boys between 1-2 years old. The diagnosis in adults is extremely rare. OBJECTIVE: To describe the clinical features of a case of Crossed testicular ectopia. CASE REPORT: Male, 35 years old, consulted for a lump of one year of evolution in inguinal region, that supine disappears and increases in size with the effort (sneeze and defecation). He denies pain, edema, detention of feces and gases. Physical examination of the inguinal region stand a tumor seen ovoid, asymmetrical from superficial ring to the scrotal sacs on the same side; supine a tumor seen ovoid, soft, renitente, reducible and intractable, above the ligament of Poupart and from deep-external inguinal ring, testis and epididymis of normal shape and size, bowel sounds (+), transillumination(-). Indirect inguinal hernia was diagnosed. During dissection and repair of the cord the presence of the double vascular bundle corresponding to both externalized testicles through the left inguinal deep hole is found. DISCUSSION: This rare disease, in most cases the diagnosis is casual, as surgical finding in patients diagnosed with inguinal hernia or cryptorchidism
Subject(s)
Humans , Male , Adult , Testis/abnormalities , Testis/surgery , OrchiopexyABSTRACT
A pig model with a deep large burn was used to study the regeneration process induced by mesenchymal stem cells (MSCs) and acellular pig dermal matrices, made intelligent by the combination with biodegradable nanofibers loaded with growth factors (granulocyte-macrophage colony-stimulating factor and epidermal growth factor) and coated with the anti-CD44 monoclonal antibody (intelligent acellular dermal matrices, IADMs). These IADMs are specially designed to integrate in the wound bed as new biological scaffolds as well as to specifically recruit and attach circulating and/or externally applied MSCs through the anti-CD44 antibody while delivering precise amounts of growth factors. In this way, the reparative process as well as the aesthetic and functional results were enhanced in our burn model. The animal survived, the wound was completely closed, and total regeneration of the skin was obtained without much scarring. Surprisingly, hair follicles and other skin appendages developed despite the severity and deepness of the burn. Even burned muscles and ribs seemed to have undergone a regenerative process by the end of the study. Based on these findings, we have proposed the use of IADMs and autologous, allogeneic or xenogeneic MSCs, as a new paradigm for the future treatment of large burns and probably other dermatological and cosmetic human conditions.
