ABSTRACT
OBJECTIVE: Neurological symptoms in patients with cat-scratch disease (CSD) have been rarely reported. The aim of this study is to analyze the frequency of neurological CSD (NCSD) and describe the disease clinical presentation, management and outcome. MATERIAL AND METHODS: We retrospectively selected patients with a CSD syndrome and Bartonella IgG titers > 1:256. Data regarding epidemiological, clinical, management, and follow-up features were analyzed and discussed. A comparison between NCSD and non-neurological CSD (NNCSD) was established. RESULTS: Thirty-nine CSD patients were selected. NCSD frequency was 10.25%. No children were found affected in the NCSD group. A 65.7% of NNCSD and the entirety of the NCSD group had a history of cat exposure. Immunosuppression was only present in the NNCSD group (8.6%). NCSD presentations were as follows: isolated aseptic meningitis (25%), neuroretinitis (50%), and isolated optic neuritis (25%). A greater proportion of patients in the NCSD group had fever and raised levels of acute phase reactants and white blood cells. 85.7% of NNCSD had a complete recovery, whereas only 50% of the NCSD patients experienced a full recovery. CONCLUSION: NCSD may be a distinctive group compared to NNCSD due to its later age of presentation, the more intense systemic response, and the poorer outcome.
Subject(s)
Bartonella henselae , Cat-Scratch Disease/epidemiology , Cat-Scratch Disease/physiopathology , Adolescent , Adult , Aged , Anti-Bacterial Agents/therapeutic use , Cat-Scratch Disease/diagnosis , Cat-Scratch Disease/therapy , Female , Fundus Oculi , Humans , Male , Middle Aged , Retrospective Studies , Treatment Outcome , Young AdultABSTRACT
OBJECTIVE: To assess ocular involvement in the pathophysiology of autosomal dominant compelling helio-ophthalmic outburst syndrome (ACHOOs). METHODS: An interview was conducted with a Caucasian family that showed clinical features of ACHOOs. Twelve of them had photic reflex and were recruited. A complete eye evaluation was made. RESULTS: A dominant autosomal inheritance with mild penetrance was demonstrated, with 67% of the studied subjects showing some degree of prominent corneal nerves. No other eye changes were found. CONCLUSIONS: Prominent corneal nerves may be associated with ACHOOs. The other eye structures studied do not seem to play a role in ACHOOs. Further studies are needed to understand the physiology of the ACHOOs.
Subject(s)
Reflex, Abnormal/radiation effects , Sneezing/genetics , Adolescent , Adult , Age of Onset , Aged , Aged, 80 and over , Child , Female , Genes, Dominant , Humans , Male , Middle Aged , Ophthalmic Nerve/ultrastructure , Pedigree , Photic Stimulation , Reflex/genetics , Spain , Sunlight , Syndrome , Young AdultABSTRACT
CASE REPORT: A 46-year-old woman, who presented with right visual acuity loss, was found to have papilledema, and subsequently shown to have ventricular dilatation in a cerebral Magnetic Resonance Imaging (MRI) assessment. Elevated protein levels were found in the cerebrospinal fluid. Spinal MRI revealed the presence of a spinal cord neoplasm. After surgical removal of the tumor, which turned out to be a neurilemmoma, the patient's visual acuity was restored. DISCUSSION: The ocular presentation and the relationship between intracranial hypertension and spinal tumors are discussed. Likewise, the importance of considering the various causes of papilledema is emphasized.
Subject(s)
Neurilemmoma/complications , Spinal Cord Neoplasms/complications , Vision Disorders/etiology , Cerebral Ventricles/pathology , Cerebrospinal Fluid Proteins/analysis , Dilatation, Pathologic/etiology , Female , Humans , Laminectomy , Magnetic Resonance Imaging , Middle Aged , Neurilemmoma/cerebrospinal fluid , Neurilemmoma/diagnosis , Neurilemmoma/surgery , Papilledema/etiology , Spinal Cord Neoplasms/cerebrospinal fluid , Spinal Cord Neoplasms/diagnosis , Spinal Cord Neoplasms/surgery , Thoracic Vertebrae , Visual Acuity , Visual Field TestsABSTRACT
We present here a patient suffering from an unilateral retinal arteriovenous communication, belonging to group 2 in Archer classification, associated to a homolateral vascular malformation into the ophthalmic artery area, and a full-thickness macular hole. This is the first case with such an association reported in the literature.
