Body Composition and Strength Parameters in Elite Judo Athletes 5 Years after Anterior Cruciate Ligament Reconstruction.

The purpose of this study was to investigate if there are still deficits in muscle mass or strength capabilities in elite judo athletes with a history of anterior cruciate ligament reconstruction (ACLR) after their return to the sport. Therefore, bioimpedance analysis, 3D-laser thigh circumference measurement and isokinetic dynamometry in a closed kinetic chain were used. The side-to-side differences were investigated in a group of judo athletes 5 years after ACLR (n=17) and compared with a group of healthy judo athletes (n=27). Neither thigh circumferences, nor muscle masses of the lower extremities differed in formerly injured judo athletes compared to healthy judo athletes. In contrast, isokinetic strength testing showed a significantly larger side-to-side difference of peak muscle force in formerly injured judo athletes (p=0.021). They provided significantly lower peak forces with the formerly injured leg than with the non-injured leg (p<0.001). The authors conclude that strength capabilities, but not body composition, remains altered in recovered judo athletes in mean 5 years after ACLR and definitely after their return to sports. This indicates that the focus of rehabilitation protocols and return to sports assessments should focus more on maximum strength capabilities.

Regular voluntary running has favorable histological effects on doxorubicin-induced kidney toxicity in Wistar rats.

Knowing the therapeutic effects of regular physical exercise on kidney toxicity induced by a single dose of doxorubicin (DOX) in animal models, the aim of this study is to verify the effectiveness of regular voluntary running on kidney histology after a prolonged DOX administration, mimicking a chemotherapy protocol. Thirty-four male Wistar rats were randomly divided into two clusters: DOX (n = 17) and SSS (sterile saline solution, n = 17), receiving a weekly intraperitoneal injection of DOX (2 mg/kg) or vehicle for 7 weeks, respectively. Two weeks after the last injection, five animals from each cluster (SSSG, n = 5; DOXG, n = 5) were euthanized, while the remaining ones were divided into sedentary (DOXsed, n = 6; SSSsed, n = 6) and active subgroups (DOXact, n = 6; SSSact, n = 6). Active animals were placed individually in cages with a running wheel for regular voluntary activity. After 2 months, the animals were euthanized and kidneys were histologically examined. Compared to SSSG, kidneys from DOXG revealed higher levels of damage, more collagen content and thickening of Bowman's capsule (p < .05). The levels of damage and thickness of Bowman's capsule increased in DOXsed as compared to DOXG (p < .05). Compared to DOXsed, the DOXact presented an overall improvement in kidney structure (p < .05), with a decrease in collagen content and of the thickness of Bowman's capsule. The results allow concluding that regular voluntary running attenuate the long-term harmful effects on kidney structure induced by a prolonged DOX treatment. These results, supporting the potential benefit of physical activity in patients under DOX treatment, need to be tested in humans.

AGREEMENT BETWEEN INSTRUMENTS FOR ASSESSMENT OF BODY BALANCE IN ACTIVE ELDERLY INDIVIDUALS / Concordância entre instrumentos para avaliação do equilíbrio corporal em idosos ativos

ABSTRACT The aim of this study was to analyze the correlation between the instruments used to assess body balance and prediction of the risk of falls of active seniors. Cross-sectional, observational study involving 41 women (69.24 ± 5.24 years) practitioners of physical exercises, in Petrolina-PE. The instruments used were the Berg Balance Scale (BBS), the Dynamic Gait Index (DGI), the "Timed Up and Go" simple (TUG), the "Timed Up and Go" motor (TUGm), the "Timed up and Go "cognitive (TUGc) and Body Balance Test (CET). Significant correlation was observed between TEC-DGI (r = 0.469; p = 0.032), BSE-DGI (r = 0.513; p = 0.021), a significant negative correlation between DGI-TUG (r = -0.454; ˂0,017), DGI -TUGm (r = -0.516; p˂0,006), DGI-TUGc (r = -0.547; ˂0,003), MMSE-TUG (r = -, 470; p = 0.055), MMSE-TUGm (r = - 470; p = 0.057) and a significant and moderate correlation between TUG-TUGm (r = 0.701; p = 0.000), TUG-TUGc (r = 0.713; p = 0.000) and TUGm-TUGc (r = 0.761; p = 0.000). It is concluded that the instruments are complementary. It is recommended their joint application to the evaluation of the body balance and to predict the risk of falls in elderly active.

RESUMO O objetivo do estudo foi analisar a correlação entre instrumentos utilizados à avaliação do equilíbrio corporal e a predição do risco de quedas de idosos ativos. Estudo transversal, observacional, realizado com 41 mulheres (69,24±5,24 anos) praticantes de exercícios físicos, em Petrolina-PE. Os instrumentos utilizados foram a Escala de Equilíbrio de Berg (EEB), o Índice de Marcha Dinâmica (DGI), o “Timed Up and Go” simples (TUG), o “Timed Up and Go” motor (TUGm), o “Timed Up and Go” cognitivo (TUGc) e o Teste de Equilíbrio Corporal (TEC). Foi observada correlação significativa entre TEC-DGI (r=0,469; p=0,032), EEB-DGI (r= 0,513; p=0,021), correlação significativa negativa entre DGI-TUG (r= -0,454; p˂0,017), DGI-TUGm (r= -0,516; p˂0,006), DGI-TUGc (r= -0,547; p˂0,003), MEEM-TUG (r= -,470; p=0,055), MEEM-TUGm (r= -,470; p=0,057) e correlação significativa e moderada entre TUG-TUGm (r=0,701; p=0,000), TUG-TUGc (r=0,713; <0,000) e TUGm-TUGc (r=0,761; <0,000). Conclui-se que os instrumentos são complementares. Recomenda-se sua aplicação conjunta à avaliação do equilíbrio corporal e à predição do risco de quedas em idosos ativos.

Bone quality: the determinants of bone strength and fragility.

Bone fragility is a major health concern, as the increased risk of bone fractures has devastating outcomes in terms of mortality, decreased autonomy, and healthcare costs. Efforts made to address this problem have considerably increased our knowledge about the mechanisms that regulate bone formation and resorption. In particular, we now have a much better understanding of the cellular events that are triggered when bones are mechanically stimulated and how these events can lead to improvements in bone mass. Despite these findings at the molecular level, most exercise intervention studies reveal either no effects or only minor benefits of exercise programs in improving bone mineral density (BMD) in osteoporotic patients. Nevertheless, and despite that BMD is the gold standard for diagnosing osteoporosis, this measure is only able to provide insights regarding the quantity of bone tissue. In this article, we review the complex structure of bone tissue and highlight the concept that its mechanical strength stems from the interaction of several different features. We revisited the available data showing that bone mineralization degree, hydroxyapatite crystal size and heterogeneity, collagen properties, osteocyte density, trabecular and cortical microarchitecture, as well as whole bone geometry, are determinants of bone strength and that each one of these properties may independently contribute to the increased or decreased risk of fracture, even without meaningful changes in aBMD. Based on these findings, we emphasize that while osteoporosis (almost) always causes bone fragility, bone fragility is not always caused just by osteoporosis, as other important variables also play a major role in this etiology. Furthermore, the results of several studies showing compelling data that physical exercise has the potential to improve bone quality and to decrease fracture risk by influencing each one of these determinants are also reviewed. These findings have meaningful clinical repercussions as they emphasize the fact that, even without leading to improvements in BMD, exercise interventions in patients with osteoporosis may be beneficial by improving other determinants of bone strength.