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ABSTRACT

A group of 13 curcuminoid pyrazoles was investigated for their cytotoxicity on three tumoral cell lines (HT-29, MCF-7, and HeLa) and one non-tumoral human cell line (HEK-293). The values obtained were compared with those of curcumin. A subset of selected derivatives was also studied for their ability to downregulate expression of the hTERT and c-Myc genes, which are both involved in telomerase activity.

Subject(s)

Curcumin/analogs & derivatives , Curcumin/pharmacology , Gene Expression Regulation, Neoplastic/drug effects , Gene Expression Regulation, Neoplastic/genetics , Pyrazoles/chemistry , Pyrazoles/pharmacology , Telomerase/genetics , Cell Line, Tumor , Cells, Cultured , Curcumin/chemical synthesis , Down-Regulation/drug effects , Humans , Proto-Oncogene Proteins c-myc/biosynthesis , Proto-Oncogene Proteins c-myc/genetics , Pyrazoles/chemical synthesis , Telomerase/biosynthesis , Telomerase/metabolism

ABSTRACT

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