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J Cancer Res Clin Oncol ; 94(2): 115-9, 1979 Jun 08.
Article in English | MEDLINE | ID: mdl-468903

ABSTRACT

By two subcutaneous or intramuscular injections of 20-methylcholanthrene (MC), 5 mg/animal in vegetal oil, followed after 74 days by 10 mg of MC emulsion, sarcomata were obtained in 63.6% of Jensen sarcoma-resistant rats (R) and in 36.8% of Jensen sarcoma-sensitive rats (S). One of the induces sarcomas, transplanted from R to R and then to S rats, presented a very high antigenicity: it strongly immunised receptive rats against the induced sarcoma and also, in a lower degree, against the Jensen sarcoma. Antigenicity was maintained up to the tenth passage.


Subject(s)
Methylcholanthrene/pharmacology , Sarcoma, Experimental/immunology , Animals , Antigens, Neoplasm , Female , Male , Neoplasm Transplantation , Rats , Rats, Inbred Strains , Sarcoma, Experimental/chemically induced
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