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1.
Int J Oral Maxillofac Implants ; 37(2): 356-364, 2022.
Article in English | MEDLINE | ID: mdl-35476865

ABSTRACT

PURPOSE: To determine clinical parameters, histologic features, and radiographic linear bone width changes of regenerated bone using different biomaterials for ridge preservation following tooth extraction. MATERIALS AND METHODS: For this pilot study, five patients were grafted with anorganic bovine bone and collagen plus recombinant human platelet-derived growth factor-BB (rhPDGF-BB), five patients were grafted with anorganic bovine bone and collagen alone, and five patients did not receive any biomaterial (control) after tooth extraction. Clinical, histologic, and radiographic evaluations were carried out 4 months postextraction. RESULTS: Differences in terms of buccolingual width were found when comparing the control group to the group grafted with anorganic bovine bone and collagen plus rhPDGF-BB (P = .012). No statistical differences were observed between the groups in terms of mineralized or nonmineralized tissue formation or in terms of the number of osteoblasts or osteocytes per mm2 after 4 months of healing. Interestingly, the number of vessels in the grafted area was found to be significantly different among the three groups (P = .005). The number of Musashi-1 positive cells was also different among groups, both in the mineralized and the nonmineralized areas of the grafted bone (P = .024 and .005, respectively). CONCLUSION: Anorganic bovine bone with bovine collagen is an efficient biomaterial to avoid postextraction resorption of the alveolar ridge. The addition of rhPDGF-BB appears to improve the biologic features of the newly formed bone and decrease bone resorption; further studies are needed for confirmation.


Subject(s)
Alveolar Ridge Augmentation , Biological Products , Animals , Becaplermin , Biocompatible Materials , Bone Regeneration , Cattle , Collagen/therapeutic use , Humans , Pilot Projects , Proto-Oncogene Proteins c-sis/therapeutic use
2.
J Prosthet Dent ; 127(4): 556-559, 2022 Apr.
Article in English | MEDLINE | ID: mdl-33341254

ABSTRACT

This article introduced a digital workflow by using data merging and a computer-aided design and computer-aided manufacturing (CAD-CAM) milled surgical guide for an esthetic crown lengthening procedure. The superimposition of intraoral scanning, digital photographs, cone beam computed tomography, and a CAD-CAM surgical guide should increase the predictability of esthetic crown lengthening surgery.


Subject(s)
Crown Lengthening , Surgery, Plastic , Computer-Aided Design , Crowns , Esthetics, Dental
3.
Article in English | MEDLINE | ID: mdl-28402346

ABSTRACT

Bone deficiencies in the jaws of edentulous patients limit the possibility of successful placement and osseointegration of endosseous implants. Bone resorption is defined as a vertical and horizontal loss of quality and quantity in the residual bone ridges; lack of bone structure requires bone grafting procedures to enable implant placement and to improve the function, predictability, and longevity of implants. The objective of this case study was to demonstrate the feasibility of a novel cell therapy treatment for localized jaw bone defects with tissue repair cells composed of a mixture of bone marrow-derived cells, including CD90+ mesenchymal stem cells and CD105+ monocytes/macrophages, and xenograft blocks, in what would be a safe and efficacious approach to the regeneration of localized craniofacial bone defects. The use of stem cells represents an alternative that could offer improved results, better quality histologically, and greater quantity in millimeters of tissue in bone regeneration.


Subject(s)
Alveolar Ridge Augmentation/methods , Bone Marrow Transplantation , Dental Implantation, Endosseous/methods , Endoglin , Maxilla/surgery , Thy-1 Antigens , Tissue Engineering , Atrophy , Bone Regeneration/physiology , Cone-Beam Computed Tomography , Feasibility Studies , Heterografts , Humans , Male , Maxilla/diagnostic imaging , Maxilla/pathology , Middle Aged , Mouth, Edentulous/diagnostic imaging , Mouth, Edentulous/surgery
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