Explorative study on lower inflection point dynamics during cardiopulmonary resuscitation: Potential implications for airway management.

INTRODUCTION: In patients undergoing cardiopulmonary resuscitation (CPR) after an Out-of-Hospital Cardiac Arrest (OHCA), intrathoracic airway closure can impede ventilation, adversely affecting patient outcomes. This explorative study investigates the evolution of intrathoracic airway closure by analyzing the lower inflection point (LIP) during the inspiration phase of CPR, aiming to identify the potential thresholds for alveolar recruitment. METHODS AND MATERIALS: Eleven OHCA patients undergoing CPR with endotracheal intubation and manual bag ventilation were included. Flow and pressure measurements were obtained using Sensirion SFM3200AW and Wika CPT2500 sensors attached to the endotracheal tube, connected to a Surface Go Tablet for data collection. Flow data was analyzed in Microsoft Excel, while pressure data was processed using the Wika USBsoft2500 application. Analysis focused on the inspiration phase of the first 6-8 breaths, with an additional 2 breaths recorded and analyzed at the end of CPR. RESULTS: Across the cohort, the median tidal volume was 870.00 milliliter (mL), average flow was 31.90 standard liters per minute (slm), and average pressure was 17.21 cmH2O. The calculated average LIP was 31.47 cmH2O. Most cases (72.7%) exhibited a negative trajectory in LIP evolution during CPR, with 2 cases (18.2%) showing a positive trajectory and 1 case remaining inconclusive. The average LIP in the first 8 breaths was significantly higher than in the last 2 breaths (p = 0.018). No significant correlation was found between average LIP and return of spontaneous circulation (ROSC), compression depth, frequency, or end-tidal CO2 (EtCO2). However, a significant negative correlation was observed between the average LIP of the last 2 breaths and CPR duration (p = 0.023). VALIDATION: LIP calculation in low-flow ventilations using the novel mathematical method yielded values consistent with those reported in the literature. DISCUSSION/CONCLUSION: These explorative data demonstrate a predominantly negative trajectory in LIP evolution during CPR, suggesting potential challenges in maintaining airway patency. Limitations include a small sample size and sensor recording issues. Further research is warranted to explore the evolution of LIP and its implications for personalized ventilation strategies in CPR.

Is the occurrence of reversed airflow in manual ventilation during cardiopulmonary resuscitation associated with reduced net tidal volumes?

Background: During cardiopulmonary resuscitation, following advanced airway placement, chest compressions and ventilations are performed simultaneously. During inspiration, chest compressions and positive pressure ventilation exert opposite forces on the respiratory system, frequently resulting in reversed airflow. Methods: Following endotracheal intubation, a flow sensor was connected to the respiratory circuit of intubated, adult out-of-hospital cardiac arrest patients receiving manual chest compressions and manual ventilations. Chest compression parameters were measured using an accelerometer. Inspiratory and expiratory volumes during the inspiratory phase of positive pressure ventilations were quantified. Duration of the inspiratory and expiratory phases was calculated. Results: In this study, 25 patients were included, 682 ventilations were analyzed. Reversed airflow was observed in 23 patients, occurring 389 times during 270 ventilations. Median volume of reversed airflow was 2 mL (IQR 1.4-7 mL). There was no difference between net tidal volumes of ventilations during which reversed airflow did (median 420 mL, IQR 315-549) or did not occur (median 406 mL, IQR 308-530). When reversed airflow occurred, the duration of the inspiratory phase was longer (median 1.2 sec, IQR 0.9-1.4) compared to ventilations without reversed airflow (median 0.9 sec, IQR 0.9-1.4). Univariate analysis showed a weak correlation between chest compression depth and volume of reversed airflow. Conclusion: Reversed airflow frequently occurs during cardiopulmonary resuscitation. Volumes of reversed airflow were small, showing a weak correlation with chest compression depth. The occurrence of reversed airflow was not associated with reduced net tidal volumes.