ABSTRACT
AIM AND BACKGROUND: There is increasing evidence that statins and oral anti-diabetic drugs, such as metformin, can have a favorable role in advanced prostate cancer treatment.Metformin has been shown to inhibit proliferation of tumor cells in vitro and statins inhibit carcinogenesis by suppressing angiogenesis/invasion mechanisms. However, clinical evidence on the protective effect of these drugs is still weak.The purpose of this study is to analyze if these drugs have an impact on Biochemical-Failure-Free-Survival (BFFS) and on Distant-Failure-Free-Survival (DFFS) in localized high-risk prostate cancer. MATERIAL AND METHODS: From 2002-2016, 447 patients with histologically confirmed high-risk prostate cancer were retrospectively evaluated. All patients received radiotherapy and androgen deprivation therapy. Biochemical recurrence was determined by the Phoenix criteria and metastatic patients were defined by the presence of radiological metastasis. Survival analysis was performed using the Kaplan-Meier method. RESULTS: 175 patients were treated with statins (65.3 % with a dose ≤ 20â¯mg/day) and 70 with metformin (75.7 % with a dose ≤ 1700â¯mg/day). Median follow-up was 88 months (1-194) with no differences in BFFS and DFFS between metformin and non-metformin patients (77.4 % versus 80 %, pâ¯=â¯0.91 and 89.4 % versus 88.7 %, pâ¯=â¯0.56, respectively). We did not find a statistical difference in BFFS and DFFS in patients taking higher doses of those drugs. CONCLUSION: Metformin and statins were not associated with BFFS or DFFS improvement in our analysis. However, the small number of patients treated with these drugs limits the reliability of the results and prospective studies are needed.
ABSTRACT
El presente artículo reporta el caso clínico y tratamiento de un paciente de 23 años de edad de sexo femenino, que asiste a la consulta por presentar aumento de volumen en la mucosa oral correspondiente a la encía del maxilar superior, lo que le impide cerrar la boca y juntar los labios, así como en la región de la tuberosidad del maxilar superior el agrandamiento gingival no le permite pasar los alimentos con facilidad, en el examen clínico se observó dientes con alteraciones compatibles con amelogenésis imperfecta. La paciente fue tratada bajo anestesia general en el quirófano, realizando tratamiento quirúrgico de gingivoplastía, osteotomía, exodóncias múltiples y prótesis fija antero superior.
This article reports the case of a patient 23 years old female, who attends consulted for increased volume in the oral mucosa corresponding to maxillary gingival, which prevents it from closing the mouth and lips together and in the region of the maxillary tuberosity gingival enlargement does not allow food to pass easily. The patient was treated under general anesthesia in the operating room, performance surgical treatment of gingivoplasty, osteotomy, multiple extractions and upper anterior fixed prosthesis.
Subject(s)
Humans , Adult , Female , Amelogenesis Imperfecta/diagnosis , Amelogenesis Imperfecta/therapy , Fibromatosis, Gingival/diagnosis , Fibromatosis, Gingival/therapyABSTRACT
El presente artículo reporta el caso clínico del traumatismo dentario de un paciente de 14 a±os de edad de sexo masculino con Parßlisis Cerebral Espßstica post-natal, que sufre una caída frontal produciéndose fractura coronaria con exposición pulpar del incisivocentral superior derecho y movilidad de la pieza dentaria por rotura de ligamento periodontal, fue tratado bajo anestesia general en centro quirúrgico realizando tratamiento de endodoncia e instalación de corona completa de acrílico como tratamiento restaurador.
The present article reports the Clinical case of a dental trauma in a 14 year-old male patient, with Post-birth Cerebral Spastic Palsy, who suffered a fall that produces a coronal fracture of an upper central incisor with pulp exposure, and mobility due to breakage of the periodontal ligament. The tooth was treated under general anesthesia in a surgical center; an endodontic treatment and a full acrylic crown were performed.
Subject(s)
Humans , Male , Adolescent , Dental Pulp Exposure , Cerebral Palsy , Tooth Injuries/surgery , Tooth Injuries/therapySubject(s)
Castleman Disease , Laparoscopy , Adult , Castleman Disease/diagnosis , Castleman Disease/surgery , Female , HumansABSTRACT
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