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1.
J Perinat Med ; 47(2): 161-168, 2019 Feb 25.
Article in English | MEDLINE | ID: mdl-30205647

ABSTRACT

Objectives To evaluate the first trimester maternal biomarkers for early pregnancy prediction of gestational diabetes mellitus (GDM). Methods The study was a case-control study of healthy women with singleton pregnancies at the first trimester carried out at the Obstetrics and Gynecology Unit, Clinica Davila, Santiago, Chile. After obtaining informed consent, peripheral blood samples of pregnant women under 14 weeks of gestation were collected. At 24-28 weeks of pregnancy, women were classified as GDM (n=16) or controls (n=80) based on the results of a 75-g oral glucose tolerance test (OGTT). In all women, we measured concentrations of fasting blood glucose, insulin, glycated hemoglobin, uric acid, cholesterol, high density lipoprotein (HDL), low density lipoprotein (LDL), very low density lipoprotein (VLDL), triglycerides, aspartate aminotransferase (AST), alanine aminotransferase (ALT), γ-glutamyl transpeptidase (GGT), alkaline phosphatase (AP), sex hormone-binding globulin (SHBG), adiponectin, tissue plasminogen activator (t-PA), leptin and placental growth factor (PGF). Results The GDM group displayed an increased median concentration of cholesterol (P=0.04), triglycerides (P=0.003), insulin (P=0.003), t-PA (P=0.0088) and homeostatic model assessment (HOMA) (P=0.003) and an increased mean concentration of LDL (P=0.009) when compared to the control group. The receiver operating characteristic (ROC) curve for significant variables achieved an area under the curve (AUC) of 0.870, a sensitivity of 81.4% and a specificity of 80.0%. The OGTT was positive for GDM according to the IADPSG (International Diabetes in Pregnancy Study Group) criteria. Conclusion Women who subsequently developed GDM showed higher levels of blood-borne biomarkers during the first trimester, compared to women who did not develop GDM. These data warrant validation in a larger cohort.


Subject(s)
Biomarkers , Cholesterol/blood , Diabetes, Gestational , Insulin/blood , Pregnancy Trimester, First/blood , Tissue Plasminogen Activator/blood , Triglycerides/blood , Adult , Alanine Transaminase/blood , Aspartate Aminotransferases/blood , Biomarkers/analysis , Biomarkers/blood , Blood Glucose/analysis , Case-Control Studies , Chile/epidemiology , Diabetes, Gestational/blood , Diabetes, Gestational/diagnosis , Diabetes, Gestational/epidemiology , Early Diagnosis , Female , Humans , Predictive Value of Tests , Pregnancy , ROC Curve , Reproducibility of Results , Sex Hormone-Binding Globulin/analysis , gamma-Glutamyltransferase/blood
2.
Gynecol Obstet Invest ; 81(3): 202-6, 2016.
Article in English | MEDLINE | ID: mdl-26836776

ABSTRACT

BACKGROUND: The objective of this study was to evaluate the association between maternal characteristics in early pregnancy and fetal growth (FG) and birth weight (BW). METHODS: A prospective cohort study was performed in unselected pregnant women who attended an ultrasound evaluation at 11-14 weeks of pregnancy. Medical history, biochemical blood tests, biophysical variables and fetal weight at 20-25 and 30-36 weeks as well as the BW were assessed. Bivariate and multivariate linear models were constructed. RESULTS: In all, 543 patients with normal pregnancy and labor were selected. The multiple regression analysis showed a statistically significant association between maternal body mass index (BMI) in early pregnancy and the uterine artery pulsatility index (UtAPI) in the first trimester with BW (p < 0.0008) and with the ratio of fetal growth between the second and third trimesters (p < 0.0001). No correlation was found between these variables and first trimester levels of hemoglobin or glycemia. CONCLUSION: Maternal first trimester BMI and UtAPI correlate with the rate of intrauterine FG and with the BW. This evidence highlights the influence of maternal first trimester variables on fetuses with normal growth and the potential role of these variables in fetal programming.


Subject(s)
Birth Weight , Fetal Development , Gestational Age , Maternal Health , Adult , Body Mass Index , Body Weight , Cohort Studies , Female , Fetal Weight , Humans , Infant, Newborn , Pregnancy , Pregnancy Trimester, First , Prospective Studies , Pulsatile Flow/physiology , Uterine Artery/physiology
3.
Gynecol Obstet Invest ; 77(3): 145-9, 2014.
Article in English | MEDLINE | ID: mdl-24401480

ABSTRACT

Gestational diabetes (GD), defined as carbohydrate intolerance with onset or first recognition during pregnancy, has a prevalence of 7% and is a growing problem worldwide. Infants born to mothers with GD are more likely to be large for gestational age, incur traumatic birth injury, require a stay in the intensive care unit and develop postnatal metabolic disturbances. As the worldwide epidemic of obesity worsens, more women are entering pregnancy with metabolic alterations and preexisting insulin resistance, which is heightened by the hormonal milieu of pregnancy. The Hyperglycemia Adverse Pregnancy Outcome (HAPO) study has clearly shown that GD-related complications correlate with glycemic control. We will review the current understanding of the physiology of GD and the screening and treatment guidelines that are commonly utilized in clinical care. In addition, we will discuss the need for development of multiparametric models combining maternal clinical risk factors and biomarkers early in pregnancy to better stratify and predict risk of GD-related complications and offer targeted intervention.


Subject(s)
Diabetes Complications/prevention & control , Diabetes, Gestational/diagnosis , Diabetes, Gestational/physiopathology , Biomarkers/blood , Blood Glucose/metabolism , Early Diagnosis , Female , Humans , Pregnancy , Risk Assessment
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