ABSTRACT
We describe the case of a patient with chronic hepatitis C (CHC) who showed a progressive increase in aminotransferase level, reaching values of aspartate aminotransferase 1723 UI/L, alanine aminotransferase 1519 UI/L and gamma-glutamyl-transpeptidase 296 with a bilirubin level of 6 mg/dL and direct bilirubin level of 4.6 mg/dL. One year previously, the patient had been diagnosed with CHC, genotype 1, and had an initial hepatitis C virus RNA load of 249,000 UI/mL. All the specific blood tests performed were negative except for antisoluble liver antigen (anti-SLA) antibodies, which were positive in two different determinations. A diagnosis of overlap syndrome CHC and autoimmune hepatitis was made. Steroid and azathioprine treatment was started with good response. The relationship between CHC and anti-SLA is not well characterized but has been described in these patients. We found no prior reports in the literature of CHC associated with positive anti-SLA in a patient with persistent acute hepatitis.
Subject(s)
Hepatitis C, Chronic/complications , Hepatitis, Autoimmune/complications , Aged , Autoantibodies/blood , Autoantigens/immunology , Biopsy, Needle , Hepatitis C Antibodies/blood , Hepatitis C, Chronic/immunology , Hepatitis C, Chronic/therapy , Hepatitis, Autoimmune/drug therapy , Hepatitis, Autoimmune/immunology , Humans , Immunosuppressive Agents/therapeutic use , Liver/immunology , Liver/pathology , Liver/virology , Liver Function Tests , Male , Treatment OutcomeSubject(s)
Diverticulum/diagnosis , Duodenal Diseases/diagnosis , Pancreatitis/diagnosis , Abscess/diagnostic imaging , Abscess/therapy , Aged , Diagnosis, Differential , Diverticulum/therapy , Duodenal Diseases/therapy , Female , Humans , Pancreatitis/therapy , Tomography, X-Ray Computed , Treatment OutcomeSubject(s)
Diarrhea/etiology , Gastrointestinal Hemorrhage/etiology , Herpesvirus 4, Human/isolation & purification , Infectious Mononucleosis/complications , Adult , Colonoscopy , Diarrhea/diagnosis , Diarrhea/therapy , Gastrointestinal Hemorrhage/diagnosis , Gastrointestinal Hemorrhage/therapy , Humans , Infectious Mononucleosis/diagnosis , Infectious Mononucleosis/therapy , Lymphocytes/pathology , Male , Rectum/pathology , Treatment OutcomeABSTRACT
No disponible
Subject(s)
Aged , Female , Humans , Tomography, X-Ray Computed , Treatment Outcome , Pancreatitis , Duodenal Diseases , Diverticulum , Diagnosis, Differential , Abscess , PancreatitisABSTRACT
We describe the case of a 27-year-old man who presented acute hepatitis due to hepatitis A virus infection. Over the following weeks he consistently presented elevated transaminase levels and jaundice. Antinuclear and anti-smooth muscle antibodies, hypergammaglobulinemia and periportal necrosis were detected in the liver biopsy. The patient was diagnosed with autoimmune hepatitis and responded well to treatment with immunosuppressive drugs. This case, as well as other published reports, suggest that in certain individuals, acute hepatitis A may be the decisive factor leading to autoimmune hepatitis.
Subject(s)
Autoimmune Diseases/etiology , Hepatitis A/complications , Hepatitis, Autoimmune/etiology , Acute Disease , Adult , Alanine Transaminase/blood , Alkaline Phosphatase/blood , Aspartate Aminotransferases/blood , Autoantibodies/analysis , Autoimmune Diseases/blood , Autoimmune Diseases/drug therapy , Azathioprine/administration & dosage , Azathioprine/therapeutic use , Biomarkers , Biopsy , Blood Donors , Drug Therapy, Combination , Hepatitis A/blood , Hepatitis, Autoimmune/blood , Hepatitis, Autoimmune/drug therapy , Humans , Hyperbilirubinemia/etiology , Hypergammaglobulinemia/etiology , Immunosuppressive Agents/therapeutic use , Liver/pathology , Male , Prednisone/administration & dosage , Prednisone/therapeutic use , gamma-Glutamyltransferase/bloodABSTRACT
OBJECTIVE: Epidemiological studies have found an increased frequency of childhood infections and tonsillectomies in patients with inflammatory bowel disease (IBD). The aim of our study was to test whether particular clinical patterns of IBD could be associated with previous tonsillectomy. METHODS: Two hundred and twenty consecutive IBD patients (100 with Crohn's disease (CD) and 120 with ulcerative colitis (UC)) were prospectively assessed and classified into groups according to disease location. In those with a positive history of tonsillectomy, an ear, nose and throat (ENT) examination was carried out to confirm the diagnosis. RESULTS: Eighty-two IBD patients (37%) underwent tonsillectomy in childhood: 47 out of 100 CD patients (47%), and 35 out of 120 UC patients (29%). Disease location in CD patients affected the ileum in 28, and 21 of them were tonsillectomized (tonsillectomy rate of 75%). Thirty-six patients had an ileocolonic location, and 14 of them had had a tonsillectomy (39%). With disease confined to the colon, only 9 out of 29 patients (31%) had undergone previous tonsillectomy. The higher prevalence of tonsillectomy in patients with CD ileitis was statistically significant (P = 0.0034). No significant differences between groups of UC patients according to the extent of the disease were found. CONCLUSION: The ileum is the most prevalent location of disease in CD patients with previous tonsillectomy.
