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World J Microbiol Biotechnol ; 31(4): 649-59, 2015 Apr.
Article in English | MEDLINE | ID: mdl-25677652

ABSTRACT

The use of poly(lactic-co-glycolic acid) (PLGA) matrix as a biomolecule carrier has been receiving great attention due to its potential therapeutic application. In this context, we investigated the PLGA matrix capacity to incorporate nisin, an antimicrobial peptide capable of inhibiting the growth of Gram-positive bacteria and bacterial spores germination. Nisin-incorporated PLGA matrices were evaluated based on the inhibitory effect against the nisin-bioindicator Lactobacillus sakei. Additionally, the PLGA-nisin matrix stability over an 8-months period was investigated, as well as the nisin release profile. For the incorporation conditions, we observed that a 5 h incorporation time, at 30 °C, with 250 µg/mL nisin solution in PBS buffer pH 4.5, resulted in the highest inhibitory activity of 2.70 logAU/mL. The PLGA-nisin matrix was found to be relatively stable and showed sustained drug delivery, with continuous release of nisin for 2 weeks. Therefore, PLGA-nisin matrix is could be used as a novel antimicrobial delivery system and an alternative to antibiotics incorporated into PLGA matrices.


Subject(s)
Anti-Bacterial Agents/chemistry , Drug Carriers/chemistry , Drug Delivery Systems/instrumentation , Lactic Acid/chemistry , Nisin/chemistry , Polyglycolic Acid/chemistry , Anti-Bacterial Agents/pharmacology , Lactobacillus/drug effects , Nanoparticles/chemistry , Nisin/pharmacology , Particle Size , Polylactic Acid-Polyglycolic Acid Copolymer
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