ABSTRACT
AIM: Eating disorders (EDs) are associated with significant disease burden and unacceptably high mortality rates. Early intervention significantly improves prognosis and can prevent chronic suffering; however, large numbers of people with the illness are not being identified or managed in primary healthcare. The current study aimed to test the reliability of the face-to-face, clinician delivery of a previously validated, co-designed, online screening tool for eating disorders. METHODS: Individuals aged 14 and over who read, English were recruited from the community in either primary care (general practice) settings or headspace youth mental health centres. They completed the InsideOut Institute Screener (IOI-S) face-to-face, delivered verbally by the study researcher clinician and then online by self-report. The primary outcome was test-retest reliability as measured by two-way mixed effects model Intraclass Correlation Coefficient (ICC) with absolute agreement. RESULTS: A total of 83 participants aged 14-81 (M 36.2) completed the study in New South Wales and the Northern Territory, Australia, between April and November 2022. The ICC between successive iterations of the test was significantly positive (0.980), demonstrating strong internal validity and test-retest reliability of the scale. CONCLUSIONS: The IOI-S is an adaptive 6-item screening tool designed to 'start a conversation' and determine risk using gentle language conceived by individuals with lived experience. Originally designed for online use, the current study broadens its versatility to clinical settings. The screener performs equally well when delivered face-to-face in clinical practice. In conjunction with increased practitioner education and improved treatment referral pathways, broad implementation of the screener in early healthcare settings can support timely identification and intervention for those with EDs.
ABSTRACT
PIP: The mechanism of the postcoital contraceptive effect of luteinizing hormone-releasing hormone (LH-RH) was studied in the rat. 200 mcg of LH-RH administered daily over Days 1-7 of pregnancy produced a dramatic inhibition of pregnancy. This inhibition was directly correlated with induced ''surges'' in serum LH over Days 1-4. Serum follicle stimulating hormone and prolactin were, in general, reduced over this same time period. A 48-hour delay in the preimplantation (Day 3) ''surge'' in serum estradiol accompanied by a significant (ps less than .05 and less than .01) reduction in serum progesterone on Days 3, 4, 6, and 7 was also observed. The delayed ''surge'' in serum estradiol on Day 5 and reduction in serum progesterone was correlated with an increase in folliculogenesis and luteolysis of established corpora lutea, respectively. These data suggest that in the rat LH-RH induces a rise in serum LH which is luteolytic during pregnancy and delays the serum estradiol surge necessary for normal implantation.^ieng
